[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100289188":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":173,"collaborators":176,"id":193,"slug":194,"hasResults":195,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":195,"sex":201,"minAge":10,"maxAge":202,"enrollmentInfo":203,"targetDuration":206,"studyType":207,"phases":10,"briefSummary":208,"conditions":209,"keywords":212,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":228},{"fullName":5,"class":6},"University Children's Hospital Basel","OTHER",[8,14,17],{"label":9,"type":10,"description":10,"interventionNames":11},"TB exposure",null,[12,13],"Diagnostic Test: Secreted cytokine assay","Diagnostic Test: Intracellular cytokine assay",{"label":15,"type":10,"description":10,"interventionNames":16},"TB infection (latent TB)",[12,13],{"label":18,"type":10,"description":10,"interventionNames":19},"TB disease (active TB)",[12,13],[21,26],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIAGNOSTIC_TEST","Secreted cytokine assay","Blood collected in a sodium-heparin tube will be used for the assay using novel TB-specific antigens. After incubation the supernatant will be harvested and cryopreserved at -80 °C for further testing of cytokines. Cytokines will be measured using a bead-based multiplex assay reader (MAGPIX, Luminex Crop., Austin, USA).",[18,9,15],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Intracellular cytokine assay","Blood will be stimulated with recombinant MTB-specific antigens, ESAT-6, CFP-10, positive control or left unstimulated. Following an initial duration of stimulation, Brefeldin-A will be added and the blood incubated for a further 5 hours. White cells will be fixed and cryopreserved at - 80°. Batched analysis within 6 months of cryopreservation will be done using multi-colour flow cytometry.",[18,9,15],[31],{"name":32,"affiliation":33,"role":34},"Nicole Ritz, Prof Dr med","UKBB","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Nina Vaezipour, Dr med","CONTACT","+41617042947","nina.vaezipour@ukbb.ch",{"name":42,"role":38,"phone":39,"phoneExt":10,"email":43},"Nicole Ritz, Prof Dr med PhD","nicole.ritz@unibas.ch",[45,63,83,97,111,127,141,157],{"facility":46,"status":47,"city":48,"state":10,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Kantonspital Aarau","RECRUITING","Aarau","5001","Switzerland","CH",{"type":53,"coordinates":54},"Point",[55,56],8.04422,47.39254,{"lat":56,"lon":55},[59],{"name":60,"role":38,"phone":61,"phoneExt":10,"email":62},"Florence Barbey, Dr med","+41628384192","florence.barbey@ksa.ch",{"facility":64,"status":47,"city":65,"state":10,"zip":66,"country":50,"countryCode":51,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Nina Vaezipour","Basel","4056",{"type":53,"coordinates":68},[69,70],7.57327,47.55839,{"lat":70,"lon":69},[73,74,76,79,81],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},{"name":75,"role":34,"phone":10,"phoneExt":10,"email":10},"Nicole Ritz, PD Dr med",{"name":77,"role":78,"phone":10,"phoneExt":10,"email":10},"Hanna Schmid, Dr med","SUB_INVESTIGATOR",{"name":80,"role":78,"phone":10,"phoneExt":10,"email":10},"Anja Jochmann, Dr med",{"name":82,"role":78,"phone":10,"phoneExt":10,"email":10},"Daniel Trachsel, PD Dr med",{"facility":84,"status":47,"city":85,"state":10,"zip":86,"country":50,"countryCode":51,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Ospedale Regionale di Bellinzona","Bellinzona","6500",{"type":53,"coordinates":88},[89,90],9.01703,46.19278,{"lat":90,"lon":89},[93],{"name":94,"role":38,"phone":95,"phoneExt":10,"email":96},"Lisa Kottanattu, Dr med","+41918118538","lisa.kottanattu@eoc.ch",{"facility":98,"status":47,"city":99,"state":10,"zip":100,"country":50,"countryCode":51,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Inselspital Bern","Bern","3010",{"type":53,"coordinates":102},[103,104],7.44744,46.94809,{"lat":104,"lon":103},[107],{"name":108,"role":38,"phone":109,"phoneExt":10,"email":110},"Andrea Duppenthaler, Dr. med.","+41316329414","andrea.duppenthaler@insel.ch",{"facility":112,"status":47,"city":113,"state":10,"zip":114,"country":50,"countryCode":51,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Hôpital des enfants - 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The CITRUS (ChIldhood TubeRcUlosis in Switzerland) Study.","CITRUS","Inclusion Criteria:\n\n* all children \u002F adolescents \\\u003C 18 years of age undergoing evaluation for TB exposure, infection or disease.\n\nExclusion Criteria:\n\n* children \u002F adolescents with TB infection or disease who have already been started on anti-mycobacterial treatment, children who have been treated for TB previously.","ALL","17 Years",{"count":204,"type":205},190,"ESTIMATED","2 Months","OBSERVATIONAL","1. The primary objective is to improve the sensitivity of novel immunodiagnostic tests for detection of TB disease in children.\n2. The secondary objective is to determine biomarkers that discriminate children with TB infection and disease.",[210,211],"Tuberculosis","Mycobacterium Tuberculosis",[213,9,214,215,216,217,218],"Immunodiagnostics tests","Latent TB","TB disease","Biomarkers","Metabolomics","NMR","2024-09-05",{"date":221,"type":222},"2024-09-19","ACTUAL",{"date":224,"type":222},"2017-05-12",{"date":226,"type":205},"2028-12",{"name":5,"class":6},8]