[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100478504":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":48,"collaborators":51,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":78,"overallStatus":81,"whyStopped":20,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients","EXPERIMENTAL","The patients who meet the inclusion criteria will receive diagnostic cervical conization for pathological examinations. Then they will be followed up for at least two years with every six months' return to our clinics to test HPV and colposcopy if necessary.",[13],"Procedure: diagnostic cervical conization",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","diagnostic cervical conization","For the patients who met the inclusion criteria, the gynecologists perform cervical conization and pathological examinations. Then the patients will be followed-up for at least two years with the tests of cervical TCT \\& HPV, and colposcopy if necessary. The data will be analyzed and see if the patients with high risk factors benefit from the surgery or not.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Shuang Li, M.D","PRINCIPAL_INVESTIGATOR",[26,30],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","18971625668","lee5190008@126.com",{"name":31,"role":27,"phone":32,"phoneExt":20,"email":33},"Dongli Kong, M.D","15107173860","kongdongli1988@163.com",[35],{"facility":36,"status":20,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":20},"Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology","Wuhan","Hubei","350000","China","CN",{"type":43,"coordinates":44},"Point",[45,46],114.26667,30.58333,{"lat":46,"lon":45},{"type":24,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Li Shuang","Professor",[52],{"name":53,"class":54},"National Natural Science Foundation of China","OTHER_GOV","100478504","diagnostic-cervical-conization-for-persistent-infection-or-integration-of-hpv-100478504",false,"NCT05510830","Diagnostic Cervical Conization for Persistent Infection or Integration of HPV","A Study of the Value of Diagnostic Cervical Conization for Persistent Infection or Integration of Human Papillomavirus","Inclusion Criteria:\n\n1. The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology.\n2. The cervical precancerous lesions are highly suspected by clinicians with one or more following risk factors:\n\n   * The course of HPV type 16\u002F18 persistent infection is more than two years.\n   * The integration reads of HPV is more than 15.\n   * The impression of colposcopy indicates precancerous lesions.\n   * The cervical TCT indicates ASC-H\u002FHSIL\u002FSCC\u002FAGC-FN\u002FAIS\u002FAC.\n\nExclusion Criteria:\n\n1. Pregnant women.\n2. Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations.\n3. The patients are suffering malignant tumors of other system and have not been cured.\n4. There is acute inflammation of the lower genital or anal tract.\n5. The patients' health will be severely harmed by the colposcopy and cervical conization due to some circumstances such as severe insufficiency of liver and kidney function, blood diseases and acute inflammation of other systems.","FEMALE","25 Years","70 Years",{"count":66,"type":67},250,"ESTIMATED","INTERVENTIONAL",[70],"NA","For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia\u002Fcancer.",[73,74,75,76,77],"Human Papilloma Virus Infection","Human Papilloma Virus Integration","Cervical Intraepithelial Neoplasia","Cervical Cancer","Cervical Conization",[79,80,17],"HPV persistent infection","HPV integration","NOT_YET_RECRUITING","2022-09-07",{"date":84,"type":85},"2022-09-08","ACTUAL",{"date":87,"type":67},"2022-10",{"date":89,"type":67},"2030-01",{"name":5,"class":6},1]