[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553159":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":24,"locations":35,"responsibleParty":52,"collaborators":23,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":23,"enrollmentInfo":64,"targetDuration":23,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":38,"whyStopped":23,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ventriculostomy-related nosocomial meningitis","EXPERIMENTAL","Finally, two neurosurgical reanimators will retrospectively diagnose nosocomial meningitis, or the absence of meningitis, according to the information from the patient's medical records.",[13],"Biological: CSF sample",{"label":15,"type":6,"description":11,"interventionNames":16},"Absence of nosocomial meningitis",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"BIOLOGICAL","CSF sample","an additional CSF sample of 1 ml is taken from the external ventriculostomy",[15,9],null,[25,31],{"name":26,"role":27,"phone":28,"phoneExt":29,"email":30},"Lucie LELIEVRE, Md","CONTACT","0561777198","+33","lelievre.l@chu-toulouse.fr",{"name":32,"role":27,"phone":33,"phoneExt":29,"email":34},"Guillaume MARTIN-BLONDEL, Md","0561779699","martin-blondel.g@chu-toulouse.fr",[36],{"facility":37,"status":38,"city":39,"state":23,"zip":23,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Toulouse Hospital","RECRUITING","Toulouse","France","FR",{"type":43,"coordinates":44},"Point",[45,46],1.44367,43.60426,{"lat":46,"lon":45},[49],{"name":50,"role":27,"phone":51,"phoneExt":23,"email":34},"Guillaume MARTIN-BLONDEL","0561778490",{"type":53,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100553159","diagnostic-of-d-lactate-in-cerebrospinal-fluid-level-in-patients-with-suspected-ventriculostomy-related-meningitis-100553159",false,"NCT06482463","Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis","Diagnostic Significance of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis : a Pilot Study","TOTEM","Inclusion Criteria:\n\n* Age ⩾ 18 years.\n* Patient with an external ventriculostomy implanted at the Toulouse University Hospital.\n* Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion.\n* Patient having expressed oral consent, after free and informed information.\n* Patient affiliated to a social security scheme.\n\nExclusion Criteria:\n\n* Diagnosis of community meningitis.\n* Proven or suspected meningitis and\u002For ventriculitis during the previous month.\n* Diagnosis of nosocomial meningitis made in another medical centre prior to admission.\n* Short bowel syndrome.\n* Acute mesenteric ischaemia.\n* End-stage renal failure (GFR \\\u003C 15 ml\u002Fmin\u002Fm2).\n* Peritoneal dialysis.\n* Patient participating in another research protocol with an exclusion period still in progress.\n* Pregnant or breastfeeding woman.\n* Patient under guardianship or trusteeship, persons placed under the protection of justice","ALL","18 Years",{"count":65,"type":66},185,"ESTIMATED","INTERVENTIONAL",[69],"NA","The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis. The study will be conducted in the neurosurgical intensive care unit of the Toulouse University Hospital, in patients with a suspected diagnosis of ventriculostomy-related nosocomial meningitis.",[72],"Nosocomial Infection",[74,75,76],"External ventriculostomy","Nosocomial meningitis","Bacterial meningitis","2025-12-23",{"date":79,"type":80},"2025-12-31","ACTUAL",{"date":82,"type":80},"2025-02-12",{"date":84,"type":66},"2027-02",{"name":5,"class":6},1]