[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567949":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":21,"collaborators":10,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":27,"acronym":28,"eligibilityCriteria":29,"healthyVolunteers":30,"sex":31,"minAge":32,"maxAge":33,"enrollmentInfo":34,"targetDuration":10,"studyType":37,"phases":10,"briefSummary":38,"conditions":39,"keywords":41,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":10},{"fullName":5,"class":6},"ANRS, Emerging Infectious Diseases","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"DEMELE-JEV Cohort 1",null,"This group will include children aged 2-14 years who present at the hospital for reasons other than infectious disease suspicion. During the study of the project, 2000 children will be recruited at each study site. All these children will be followed up at one year and two years post-inclusion",{"label":13,"type":10,"description":14,"interventionNames":10},"DEMELE-JEV Cohort 2","This group will include children aged 2-14 years who are hospitalized with febrile neurological syndrome (FNS)",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Diana Molino, PhD","CONTACT","+33 1 53 94 60 76","diana.molino@inserm.fr",{"type":22,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100567949","diagnostics-and-surveillance-of-acute-meningo-encephalitis-among-children-in-cambodia-with-a-focus-on-japanese-encephalitis-virus-100567949",false,"NCT06674837","Diagnostics and Surveillance of Acute Meningo-encephalitis Among Children in Cambodia With a Focus on Japanese Encephalitis Virus","DEMELE-JEV","Inclusion Criteria:\n\nCohort 1\n\n* All children aged between 2 and 14 years.\n* No fever or history of fever in the past 14 days.\n* Consenting to return to the hospital for follow-up visits.\n* Consenting to blood sampling.\n* Written informed assent\u002Fconsent to participate in the study.\n\nCohort 2\n\n* Hospitalized patients aged between 2 and 14 years.\n* Any neurological disorder.\n* Any fever within the past 72 hours.\n* Written informed assent\u002Fconsent to participate in the study.\n* No contraindication for lumbar puncture (LP).",true,"ALL","2 Years","14 Years",{"count":35,"type":36},4000,"ESTIMATED","OBSERVATIONAL","The primary objective of this study is to quantify the clinical burden of Japanese Encephalitis (JE) and the asymptomatic circulation of JEV among Cambodian children, through two pediatric cohorts: non-febrile children at recruitment and children hospitalized with febrile neurological syndrome (FNS). Secondary objectives include estimating anti-JEV seropositivity rates, identifying individual risk factors and living conditions associated with JEV infection, characterizing clinical and biological profiles related to disease severity, and evaluating the role of deficiencies in interferon (IFN) response in severe JEV infections.",[40],"Japanese Encephalitis",[42,43],"Japanese encephalitis","arbovirus","NOT_YET_RECRUITING","2025-09-10",{"date":47,"type":48},"2025-09-11","ACTUAL",{"date":50,"type":36},"2025-10-15",{"date":52,"type":36},"2028-01",{"name":5,"class":6}]