[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100455523":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":28,"locations":37,"responsibleParty":60,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":10,"studyType":77,"phases":10,"briefSummary":78,"conditions":79,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"RWTH Aachen University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Invasively ventilated patients (n=15)",null,"First measurement (comprehensive protocol) within 48 hours from initiation of MV.\n\nSerial measurements every third day including 2 measurements after extubation.",[13],"Diagnostic Test: Respiratory Muscle Testing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Respiratory Muscle Testing","Comprehensive assessment of respiratory muscle function. Comprehensive assessment of respiratory muscle function to the point of its invasive assessment with recordings of twitch transdiaphragmatic pressure in response to magnetic phrenic nerve stimulation and stimulation of the lower thoracic nerve roots.",[9],[21,25],{"name":22,"affiliation":23,"role":24},"Michael Dreher, Professor","RWTH Aachen University Hospital","STUDY_CHAIR",{"name":26,"affiliation":23,"role":27},"Jens Spiesshoefer, MD","PRINCIPAL_INVESTIGATOR",[29,34],{"name":22,"role":30,"phone":31,"phoneExt":32,"email":33},"CONTACT","+4924180","88763","mdreher@ukaachen.de",{"name":26,"role":30,"phone":31,"phoneExt":35,"email":36},"37036","jspiesshoefe@ukaachen.de",[38],{"facility":5,"status":39,"city":40,"state":10,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Aachen","52074","Germany","DE",{"type":45,"coordinates":46},"Point",[47,48],6.08342,50.77664,{"lat":48,"lon":47},[51,52,53,56,58],{"name":22,"role":30,"phone":31,"phoneExt":32,"email":33},{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"name":54,"role":55,"phone":10,"phoneExt":10,"email":10},"Binaya Regmi, MD","SUB_INVESTIGATOR",{"name":57,"role":55,"phone":10,"phoneExt":10,"email":10},"Jonathan Enriquez-Geppert",{"name":59,"role":55,"phone":10,"phoneExt":10,"email":10},"Mehdi Senol",{"type":27,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Univ.-Prof. Dr. med. Michael Dreher","Professor Michael Dreher","100455523","diaphragm-atrophy-and-dysfunction-in-mechanical-ventilation-100455523",false,"NCT05211661","Diaphragm Atrophy and Dysfunction in Mechanical Ventilation","Development of Diaphragm Atrophy, Dysfunction and Inhibited Cortical Control in Mechanical Ventilation","DAM","Inclusion Criteria:\n\n* Initiation of invasive mechanical ventilation in the Intensive Care Unit within 48 hours.\n* Expected duration of invasive mechanical ventilation of at least 5 days.\n\nExclusion Criteria:\n\n* Body-mass-index (BMI) \\>40\n* Expected absence of active participation of the patient in study-related measurements after extubation\n* Alcohol or drug abuse\n* Non MRI compatible implant in the body\n* Slipped disc\n* Epilepsy\n* Patients in an interdependence or with an employment contract with the principal investigator, Co-PI or his deputy.","ALL","18 Years","75 Years",{"count":75,"type":76},15,"ESTIMATED","OBSERVATIONAL","The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.\n\nThrough measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD.\n\nPaired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex.\n\nAgainst that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).",[80,81,82,83],"Diaphragm Issues","Mechanical Ventilation Complication","Respiratory Failure","Intensive Care (ICU) Myopathy","2026-02-04",{"date":86,"type":87},"2026-02-09","ACTUAL",{"date":89,"type":87},"2022-10-10",{"date":91,"type":76},"2028-06-01",{"name":5,"class":6},1]