[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100336945":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":30,"locations":37,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":10,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":78,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients undergoing LTx with respiratory failure (cases)",null,"Patients are receiving a respiratory support modality (mechanical ventilation and\u002For extracorporeal life support) as a bridge to lung transplantation (LTx).",[13],"Device: Respiratory support",{"label":15,"type":10,"description":16,"interventionNames":10},"Patients undergoing LTx without prior respiratory support","Patients undergoing lung transplantation but do not require prior bridging respiratory support.",{"label":18,"type":10,"description":19,"interventionNames":10},"Elective thoracic surgical patients","Patients undergoing elective thoracic surgery for planned lung or esophageal resection.",[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DEVICE","Respiratory support","Mechanical ventilation or extracorporeal life support",[9],[27],{"name":28,"affiliation":5,"role":29},"Ewan Goligher, MD, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Rongyu (Cindy) Jin","CONTACT","416-340-4800","7613","rongyu.jin@uhn.ca",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":10,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Toronto General Hospital","RECRUITING","Toronto","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-79.39864,43.70643,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":53,"phoneExt":35,"email":54},"Jenna Wong, MSc","4163404800","jenna.wong@uhn.ca",{"type":56,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[58],{"name":59,"class":6},"The Hospital for Sick Children","100336945","diaphragm-structure-and-pathobiology-in-patients-being-bridged-to-lung-transplant-100336945",false,"NCT03667027","Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant","DIASPORA","Inclusion Criteria (Cases):\n\n* Receiving a respiratory support modality as a bridge to lung transplantation\n* Formally listed for transplantation\n\nInclusion Criteria (Control Group 1):\n\n\\- Undergoing lung transplantation for either obstructive or restrictive lung disease\n\nInclusion Criteria (Control Group 2):\n\n\\- Undergoing elective thoracic surgery without any prior history of chronic pulmonary parenchymal disease\n\nExclusion Criteria (Cases and Controls):\n\n* Previously diagnosed with neuromuscular disorder\n* Received invasive mechanical ventilation for \\>48 hours in the preceding four weeks\n* Thoracic cage deformity","ALL","18 Years",{"count":70,"type":71},40,"ESTIMATED","OBSERVATIONAL","This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.",[75,76,77],"Diaphragm Injury","Respiratory Failure","Mechanical Ventilation Complication",[79,80,81],"Diaphragm Dysfunction","Acute Respiratory Failure","Mechanical Ventilation","2024-12-06",{"date":84,"type":85},"2024-12-11","ACTUAL",{"date":87,"type":85},"2019-04-01",{"date":89,"type":71},"2025-12-30",{"name":5,"class":6},1]