[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627167":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":42,"centralContacts":43,"locations":49,"responsibleParty":62,"collaborators":42,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":42,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":42,"enrollmentInfo":76,"targetDuration":42,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":89,"whyStopped":42,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Jaén","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group 1. SDB 6x 6","EXPERIMENTAL","Guided breathing at 6 breaths per minute (bpm) with an inspiration (I) to expiration (E) ratio of 1:1",[13],"Procedure: Guided breathing at 6 bpm with apnea (A)",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental Group 2. SDB 6x6x6","Guided breathing at 6 bpm with apnea (A) and an I:E:A ratio of 1:1:1.",[18],"Procedure: Guided breathing at 6 breaths per minute (bpm) with an inspiration (I) to expiration (E)",{"label":20,"type":21,"description":22,"interventionNames":23},"Control Group","PLACEBO_COMPARATOR","Breathing education",[24],"Procedure: Breathing education",[26,33,38],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"PROCEDURE","Guided breathing at 6 breaths per minute (bpm) with an inspiration (I) to expiration (E)","Spontaneous breathing in adults typically ranges between 12 and 20 breaths per minute (bpm), whereas slow, deep breathing (SDB) is usually performed as guided breathing at approximately 4 to 6 bpm.",[15],[32],"Experimental Group 1. SDB 6x6",{"type":27,"name":34,"description":29,"armGroupLabels":35,"otherNames":36},"Guided breathing at 6 bpm with apnea (A)",[9],[37],"Experimental Group 2.SDB 6x6x6",{"type":27,"name":22,"description":39,"armGroupLabels":40,"otherNames":41},"Breathing education consists of teaching individuals to understand, control, and optimize their breathing patterns.",[20],[20],null,[44],{"name":45,"role":46,"phone":47,"phoneExt":42,"email":48},"Ana Sedeño Vidal, Full time professor","CONTACT","34 654428130","asedeno@ujaen.es",[50],{"facility":51,"status":42,"city":52,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":42},"University of Jaen","Jaén","23071","Spain","ES",{"type":57,"coordinates":58},"Point",[59,60],-3.79028,37.76922,{"lat":60,"lon":59},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Ana Sedeño Vidal","Full Professor","100627167","diaphragmatic-breathing-and-stimulation-of-the-autonomic-nervous-system-100627167",false,"NCT07445113","Diaphragmatic Breathing and Stimulation of the Autonomic Nervous System","Influence of Diaphragmatic Breathing Through Slow, Deep Respiration on Vagal Nerve Modulation and Stimulation of the Autonomic Nervous System","Inclusion Criteria:\n\n* Healthy individuals who have not smoked during the 24 hours prior to the study.\n* Healthy individuals who have not drunk alcohol during the 24 hours prior to the study.\n* Healthy individuals who have not drunk coffee during the 24 hours prior to the study.\n\nExclusion Criteria:\n\n* Individuals with cardiovascular diseases or neurological disorders.\n* Individuals with cognitive impairment.\n* Individuals taking medications that affect autonomic nervous system function, such as: benzodiazepines, beta-blockers or beta-adrenergic agents.",true,"ALL","18 Years",{"count":77,"type":78},60,"ESTIMATED","INTERVENTIONAL",[81],"NA","Introduction:\n\nSlow, deep breathing has demonstrated beneficial effects on the autonomic nervous system, particularly by increasing parasympathetic activity through vagal nerve modulation. Previous studies suggest that this breathing pattern optimizes the sympathovagal balance, modifies physiological parameters such as heart rate, blood pressure, and oxygen saturation, and influences variables including heart rate variability (HRV) and RR intervals.\n\nObjectives:\n\nTo analyze the effects of different slow deep breathing (SDB) training modalities on vagal tone regulation. Secondary objectives include evaluating their impact on heart rate and rhythm, HRV, cardiac beat intervals, blood pressure, and oxygen saturation.\n\nMethodology:\n\nA randomized, controlled, single-blind, parallel-design clinical trial will be conducted. Sixty healthy participants will be enrolled and allocated into three groups: two experimental groups (SDB with and without apnea) and one control group (breathing education). Pre- and post-intervention measurements will include HRV, RR intervals, heart rate, blood pressure, oxygen saturation, and cervical joint variables. Data will be analyzed using repeated-measures ANOVA and statistical tests appropriate for each variable type, with a significance level set at 5%.\n\nExpected Results:\n\nSDB-based interventions are expected to produce significant improvements in vagal regulation, increasing heart rate variability and favorably modifying the aforementioned physiological parameters compared with the control group.",[84],"Healthy Adult Male and Female Volunteers",[86,87,88],"Slow diaphragmatic breathing","autonomic nervous system","heart rate variability","NOT_YET_RECRUITING","2026-03-03",{"date":92,"type":93},"2026-03-05","ACTUAL",{"date":95,"type":78},"2026-02-15",{"date":97,"type":78},"2026-05-31",{"name":5,"class":6},1]