[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593204":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":10,"centralContacts":31,"locations":37,"responsibleParty":54,"collaborators":10,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":10,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Nanjing Medical University","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal Group",null,"Healthy subjects with no known respiratory diseases or sleep disorders, serving as the control group for baseline comparison of diaphragmatic function and respiratory drive.",[13],"Other: Diaphragmatic Ultrasound and EMG Assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"OSA Group","Patients diagnosed with obstructive sleep apnea (OSA) based on polysomnography criteria (AHI ≥ 5 events\u002Fhour), evaluated for diaphragmatic function and respiratory drive using ultrasound and EMG.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"COPD Group","Patients diagnosed with chronic obstructive pulmonary disease (COPD) based on GOLD guidelines, assessed for diaphragmatic morphofunction and respiratory drive.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Overlap Group","Patients with overlap syndrome (coexisting OSA and COPD), evaluated for diaphragmatic function and respiratory drive using ultrasound and EMG to explore combined disease impact.",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Diaphragmatic Ultrasound and EMG Assessment","Non-invasive assessment of diaphragmatic morphofunction and respiratory drive using ultrasound imaging and diaphragm electromyography (EMG). This evaluation will be performed once per participant without any therapeutic intervention.",[19,9,15,23],[32],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},"Ding Ning, doctor","CONTACT","86-25-68136723","dr.ningding@live.cn",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"The First Affiliated Hospital of Nanjing Medical University","RECRUITING","Nanjing","Jiangsu","210029","China","CN",{"type":47,"coordinates":48},"Point",[49,50],118.77778,32.06167,{"lat":50,"lon":49},[53],{"name":33,"role":34,"phone":35,"phoneExt":10,"email":36},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ning Ding","Principal Investigator","100593204","diaphragmatic-function-and-respiratory-drive-in-osa-and-copd-100593204",false,"NCT07003399","Diaphragmatic Function and Respiratory Drive in OSA and COPD","Diaphragmatic Morphofunction and Respiratory Drive in OSA and COPD: Insights From Ultrasound and EMG-based Cross-Sectional Analysis","Inclusion Criteria:\n\n1. Patients aged between 18 and 80 years.\n2. For OSA Group: Diagnosed obstructive sleep apnea with AHI ≥ 5 events\u002Fhour based on overnight polysomnography.\n3. For COPD Group: Diagnosed chronic obstructive pulmonary disease based on GOLD guidelines.\n4. For Overlap Group: Diagnosed both OSA (AHI ≥ 5) and COPD.\n5. For Control Group: Healthy volunteers with no known respiratory diseases or sleep disorders.\n6. Ability and willingness to provide informed consent for participation in the study.\n\nExclusion Criteria:\n\n1. Severe cardiovascular diseases (e.g., unstable angina, heart failure NYHA III\u002FIV).\n2. Severe hepatic or renal insufficiency.\n3. Neuromuscular diseases affecting respiratory muscles.\n4. Recent upper airway or thoracic surgery (within 3 months).\n5. Pregnancy or breastfeeding.\n6. Participants who cannot complete assessments due to cognitive impairment or poor cooperation.",true,"ALL","18 Years","80 Years",{"count":70,"type":71},80,"ESTIMATED","OBSERVATIONAL","This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), overlap syndrome (OS), and healthy controls. Using ultrasound imaging and surface diaphragm electromyography (EMGdi), the study will explore group differences in diaphragmatic morphology, function, and respiratory drive indicators, and evaluate their clinical significance in disease differentiation and severity assessment.",[75],"Obstructive Sleep Apnea",[75,77,78],"Chronic Obstructive Pulmonary Disease","Overlap Syndrome","2025-06-24",{"date":81,"type":82},"2025-06-25","ACTUAL",{"date":84,"type":82},"2025-01-01",{"date":86,"type":71},"2025-08-31",{"name":5,"class":6},1]