[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508636":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":93,"centralContacts":115,"locations":120,"responsibleParty":141,"collaborators":10,"id":144,"slug":145,"hasResults":146,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":146,"sex":152,"minAge":153,"maxAge":10,"enrollmentInfo":154,"targetDuration":10,"studyType":157,"phases":10,"briefSummary":158,"conditions":159,"keywords":166,"overallStatus":122,"whyStopped":10,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":181},{"fullName":5,"class":6},"RWTH Aachen University","OTHER",[8,24,28,31],{"label":9,"type":10,"description":10,"interventionNames":11},"Patients with Asthma",null,[12,13,14,15,16,17,18,19,20,21,22,23],"Diagnostic Test: Diaphragm Ultrasound","Diagnostic Test: Intercostal Muscle Ultrasound","Diagnostic Test: Borg scale","Diagnostic Test: MRC Breathlessness Scale","Diagnostic Test: Respiratory Questionaire","Diagnostic Test: GINA classification of Asthma","Diagnostic Test: Measurement of respiratory mouth pressure","Diagnostic Test: SNIP","Diagnostic Test: 6-minute walking distance","Diagnostic Test: 60 seconds sit-to-stand test","Diagnostic Test: Electromyography","Diagnostic Test: Lung Function",{"label":25,"type":10,"description":10,"interventionNames":26},"Patients with COPD",[12,13,14,15,16,18,19,20,21,22,23,27],"Diagnostic Test: CAT-Questionnaire",{"label":29,"type":10,"description":10,"interventionNames":30},"Patients with Fibrosis",[12,13,14,15,16,18,19,20,21,22,23],{"label":32,"type":10,"description":10,"interventionNames":33},"Patients with Pulmonary Hypertension",[12,13,14,15,16,18,19,20,21,22,23,34],"Diagnostic Test: European Society of Cardiology (ESC)\u002F European Respiratory Society (ERS) risk group",[36,41,45,49,53,57,61,65,69,73,77,81,85,89],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":10},"DIAGNOSTIC_TEST","Diaphragm Ultrasound","Ultrasound of the Diaphragm at the end of inspiration and expiration",[9,25,29,32],{"type":37,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"Intercostal Muscle Ultrasound","Ultrasound of the Intercostal Muscles at the end of inspiration and expiration",[9,25,29,32],{"type":37,"name":46,"description":47,"armGroupLabels":48,"otherNames":10},"Borg scale","Questionnaire for Perceived Exertion (Borg Rating of Perceived Exertion Scale)",[9,25,29,32],{"type":37,"name":50,"description":51,"armGroupLabels":52,"otherNames":10},"MRC Breathlessness Scale","The MRC Dyspnoea Scale allows the patients to indicate the extent to which their breathlessness affects their mobility.",[9,25,29,32],{"type":37,"name":54,"description":55,"armGroupLabels":56,"otherNames":10},"Respiratory Questionaire","Specialized respiratory questionnaire with different domains (Emotional Domain, Dyspnea Domain, Mastery Domain, Fatigue Domain)",[9,25,29,32],{"type":37,"name":58,"description":59,"armGroupLabels":60,"otherNames":10},"GINA classification of Asthma","Patients are classified according to the GINA classification of Asthma.",[9],{"type":37,"name":62,"description":63,"armGroupLabels":64,"otherNames":10},"Measurement of respiratory mouth pressure","Inspiratory and expiratory Measurement of respiratory mouth pressure",[9,25,29,32],{"type":37,"name":66,"description":67,"armGroupLabels":68,"otherNames":10},"SNIP","Measurement of Sniff Nasal Inspiratory Pressure",[9,25,29,32],{"type":37,"name":70,"description":71,"armGroupLabels":72,"otherNames":10},"6-minute walking distance","The maximum walking distance achieved in 6 minutes",[9,25,29,32],{"type":37,"name":74,"description":75,"armGroupLabels":76,"otherNames":10},"60 seconds sit-to-stand test","number of repetitions achieved in sitting down and standing up in 60 seconds",[9,25,29,32],{"type":37,"name":78,"description":79,"armGroupLabels":80,"otherNames":10},"Electromyography","electromyography of the muscles of respiration via superficial electrodes",[9,25,29,32],{"type":37,"name":82,"description":83,"armGroupLabels":84,"otherNames":10},"Lung Function","Measurement of lung function via body plethysmography",[9,25,29,32],{"type":37,"name":86,"description":87,"armGroupLabels":88,"otherNames":10},"CAT-Questionnaire","COPD Assessment Test (CAT)",[25],{"type":37,"name":90,"description":91,"armGroupLabels":92,"otherNames":10},"European Society of Cardiology (ESC)\u002F European Respiratory Society (ERS) risk group","Patients with pulmonary hypertension are classified according to the ESC\u002FERS risk group.",[32],[94,98,101,104,106,108,110,112],{"name":95,"affiliation":96,"role":97},"Michael Dreher, MD","Uniklinik RWTH Aachen","STUDY_DIRECTOR",{"name":99,"affiliation":96,"role":100},"Binaya Regmi, MD","STUDY_CHAIR",{"name":102,"affiliation":96,"role":103},"Jens Spiesshoefer, MD","PRINCIPAL_INVESTIGATOR",{"name":105,"affiliation":96,"role":100},"Mustafa Elfeturi",{"name":107,"affiliation":96,"role":100},"Benedikt Jörn",{"name":109,"affiliation":96,"role":100},"Faniry Ratsimba",{"name":111,"affiliation":96,"role":100},"Felix Wagner",{"name":113,"affiliation":114,"role":100},"Maria Aetou, Dr. med.","RWTH Aachen University Hospital",[116],{"name":102,"role":117,"phone":118,"phoneExt":10,"email":119},"CONTACT","0049 2418037036","jspiesshoefer@ukaachen.de",[121],{"facility":114,"status":122,"city":123,"state":124,"zip":125,"country":126,"countryCode":127,"cosmosGeoPoint":128,"geoPoint":133,"contacts":134},"RECRUITING","Aachen","North Rhine-Westphalia","52074","Germany","DE",{"type":129,"coordinates":130},"Point",[131,132],6.08342,50.77664,{"lat":132,"lon":131},[135,138],{"name":136,"role":117,"phone":137,"phoneExt":10,"email":119},"Jens Spiesshoefer, PhD","+492418037036",{"name":99,"role":117,"phone":139,"phoneExt":10,"email":140},"+492418037065","bregmi@ukaachen.de",{"type":103,"investigatorFullName":142,"investigatorTitle":143,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jens Spießhöfer","PD Dr. med.","100508636","diaphragmatic-function-as-a-biomarker-100508636",false,"NCT05903001","Diaphragmatic Function as a Biomarker","Diaphragmatic Function as a Biomarker in Patients With Respiratory Diseases","DFUNBIO","Inclusion Criteria:\n\n* patient has one of the following lung diseases: COPD, bronchial asthma, pulmonary fibrosis, pulmonary hypertension\n* is 18 years or older\n* is mentally and physically able to understand the study and to follow instructions\n* are legally competent\n* signed declaration of consent\n\nExclusion Criteria:\n\n* BMI \\> 35\n* current or treatments or diseases in the past which could influence the evaluation of the study\n* Expected lack of willingness to actively participate in study-related measures\n* alcohol or drug abuse\n* disc herniation\u002Fprolapse\n* epilepsy\n* wheelchair bound\n* in custody due to an official or court order\n* in a dependent relationship or employment relationship with investigating physician or one of their deputy\n* emergency inpatient hospital stay within 4 weeks before study-specific examinations","ALL","18 Years",{"count":155,"type":156},800,"ESTIMATED","OBSERVATIONAL","Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension. However, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. Diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. The association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.",[160,161,162,163,164,165],"Dyspnea; Asthmatic","COPD","Fibrosis","Pulmonary Hypertension","Asthma","Dyspnea",[167,161,168,169,170,171],"dyspnea","asthma","fibrosis","pulmonary hypertension","pneumology","2026-01-26",{"date":174,"type":175},"2026-01-28","ACTUAL",{"date":177,"type":175},"2023-07-01",{"date":179,"type":156},"2026-12-30",{"name":5,"class":6},1]