[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620652":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":26,"locations":32,"responsibleParty":50,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":11,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":11,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":79,"whyStopped":11,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"American University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Diet group","ACTIVE_COMPARATOR",null,[13],"Behavioral: Dietary training",{"label":15,"type":16,"description":17,"interventionNames":11},"Control group","NO_INTERVENTION","This group will follow their own diet without any intervention. However after this period, they will given the chance of receiving intervention as well.",[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Dietary training","Subjects will undergo a 2-hour online training session to teach them how to follow the low glutamate diet. The low glutamate diet is a healthy, whole-food diet designed to limit the intake of free glutamate\u002Faspartate, while also emphasizing the consumption of foods which are high in nutrients that protect against glutamate excitotoxicity and oxidative stress.",[9],[25],"Low glutamate diet",[27],{"name":28,"role":29,"phone":30,"phoneExt":11,"email":31},"Kathleen Holton","CONTACT","5037571578","holton@american.edu",[33],{"facility":5,"status":11,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Washington D.C.","District of Columbia","20016","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-77.03637,38.89511,{"lat":43,"lon":42},[46],{"name":47,"role":29,"phone":48,"phoneExt":11,"email":49},"Houra Taheri","(202) 885-3810","htaheri@american.edu",{"type":51,"investigatorFullName":28,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Professor",[54],{"name":55,"class":6},"Georgetown University","100620652","dietary-intervention-for-migraine-relief-100620652",false,"NCT07360405","Dietary Intervention for Migraine Relief","Diet-Based Treatment for Migraine Relief","Inclusion Criteria:\n\n* Men and women of all races and ethnicities\n* Age 18-75 years\n* Documented diagnosis of chronic or episodic migraine for at least 6 months, based on International Classification of Headache Disorders, 3rd edition (ICHD-III) criteria, defined as:\n\n  * 8 headache days per month, and\n  * 4 migraine days per month\n* Migraine onset before age 50\n* On a stable medication regimen for at least 1 month prior to enrollment\n* Willing to maintain stable medications throughout the study\n* Willing to discontinue supplements during the study period\n* Women of childbearing potential must be willing to use birth control during the study timeframe\n\nExclusion Criteria:\n\n* Current pregnancy, plans to become pregnant during the study timeframe, or current breastfeeding\n* Current use of medications affecting glutamatergic or gamma-Aminobutyric Acid (GABA) neurotransmission (unless discontinued under physician guidance)\n* Current use of quarterly injectable migraine preventive medications\n* Unwillingness to modify dietary intake or to stop alcohol and marijuana use during the study\n* Substance use disorder within the past year\n* Diagnosed seizure disorder\n* Severe asthma requiring past hospitalization","ALL","18 Years","75 Years",{"count":67,"type":68},40,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this clinical trial is to evaluate whether a low-glutamate diet can improve migraine symptoms in adults with migraine and to explore possible biological changes associated with dietary improvement. The study focuses on whether reducing dietary glutamate intake may influence processes involved in migraine, such as brain excitation, inflammation, and oxidative stress.\n\nThe main questions this study aims to answer are:\n\nDoes following a low-glutamate diet reduce the number of migraine days and the severity and duration of migraine attacks, and improve quality of life?\n\nAre improvements in migraine symptoms associated with changes in blood-based biological markers related to migraine activity?\n\nResearchers will compare participants assigned to the low-glutamate diet with participants assigned to a wait-list control group to evaluate differences in migraine outcomes and related biological measures.\n\nParticipants will:\n\nComplete a baseline run-in period while tracking headaches using a daily migraine diary\n\nEither follow a low-glutamate dietary intervention or continue their usual diet as part of a wait-list control\n\nComplete standardized questionnaires related to migraine symptoms and quality of life\n\nProvide blood samples for laboratory analyses\n\nUndergo neuroimaging assessments (for a subset of participants)",[74],"Migraine",[74,76,77,78],"Chronic pain","Diet","Glutamate","NOT_YET_RECRUITING","2026-01-16",{"date":82,"type":83},"2026-01-22","ACTUAL",{"date":85,"type":68},"2026-01",{"date":87,"type":68},"2027-03",{"name":5,"class":6},1]