[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574522":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":44,"collaborators":18,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":18,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":75,"whyStopped":18,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Universidad Complutense de Madrid","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Dietary supplement Group","EXPERIMENTAL","Subjects belonging to the experimental group will be provided with the PermeaIntest supplement, which they will take for 60 days, 1 sachet in the morning and 1 sachet in the evening in half a glass of water. Subjects will have a stool sample collected before and after ingestion of the dietary supplement.",[13],"Dietary Supplement: Dietary supplement Group",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","A control group of subjects not receiving any type of supplementation will be used to compare the effectiveness of the treatment. Subjects will have a stool sample collected before and after a period of 60 days",null,[20],{"type":21,"name":9,"description":11,"armGroupLabels":22,"otherNames":18},"DIETARY_SUPPLEMENT",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Isidro Fernández-López Dr. Fernández-López, PT PhD","CONTACT","346255989770","isidrofe@ucm.es",[30],{"facility":5,"status":18,"city":31,"state":18,"zip":18,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Madrid","Spain","ES",{"type":35,"coordinates":36},"Point",[37,38],-3.70256,40.4165,{"lat":38,"lon":37},[41],{"name":42,"role":26,"phone":43,"phoneExt":18,"email":28},"Isidro Fernández-López Isidro Fernández-López, PT PhD","34625598970",{"type":45,"investigatorFullName":46,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Isidro Fernández López","Principal investigator","100574522","dietary-supplements-for-reduction-of-intestinal-permeability-levels-100574522",false,"NCT06760377","Dietary Supplements for Reduction of Intestinal Permeability Levels","permeability","Inclusion Criteria:\n\n* Subjects between 18 and 65 years of age with elevated levels of zonulin in stool (greater than 80 ng\u002Fml).\n\nExclusion Criteria:\n\n* Taking any type of antibiotic in the last month\n* Taking prebiotics or probiotics products in the last month.\n* Taking laxatives in the last month.\n* Undergoing any medicinal treatment\n* Pregnancy\n* Subject with a history of current gastrointestinal pathology or disorder such as: acute colon pathology, acute haemorrhagic colitis, suspected digestive perforation, recent abdominal surgery, severe arterial hypertension, abdominal hernia, colon neoplasia, history of cardiac syncope, renal failure, liver cirrhosis, epilepsy, severe psychiatric illness (psychosis), necrosis due to abdominal irradiation, severe anaemia, severe neurovegetative lability.",true,"ALL","18 Years","65 Years",{"count":60,"type":61},85,"ESTIMATED","INTERVENTIONAL",[64],"NA","A randomised and controlled trial, in which the effect of a dietary supplement is evaluated for reduction of intestinal permeability levels of subjects with high levels of zonulin in feces",[67,68,69],"Intestinal Permeability","Leaky Gut Syndrome","Zonulin",[71,72,73,74],"intestinal permeability","leaky gut syndrome","zonulin","tight junctions","NOT_YET_RECRUITING","2024-12-29",{"date":78,"type":79},"2025-01-06","ACTUAL",{"date":81,"type":61},"2025-02-01",{"date":83,"type":61},"2025-06-01",{"name":5,"class":6},1]