[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581615":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":69,"collaborators":71,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":82,"sex":88,"minAge":89,"maxAge":11,"enrollmentInfo":90,"targetDuration":11,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":41,"whyStopped":11,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Diet with additional fructose intake","EXPERIMENTAL",null,[13],"Dietary Supplement: Fructose",{"label":15,"type":10,"description":11,"interventionNames":16},"Diet with additional fructose and galactose intake",[17],"Dietary Supplement: Fructose and galactose",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DIETARY_SUPPLEMENT","Fructose","40g fructose (free and bound, max amount of fructose from added free sugar\u002Fsaccharose 25g)",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Fructose and galactose","10g galactose (mostly from lactose) plus 40g of fructose (free and bound, max amount of fructose from added free sugar\u002Fsaccharose 25g)",[15],[29],{"name":30,"affiliation":31,"role":32},"Michel Hochuli, MD, PhD","Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism","PRINCIPAL_INVESTIGATOR",[34],{"name":30,"role":35,"phone":36,"phoneExt":11,"email":37},"CONTACT","+41 31 664 03 18","michel.hochuli@insel.ch",[39,54],{"facility":40,"status":41,"city":42,"state":11,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital","RECRUITING","Bern","3010","Switzerland","CH",{"type":47,"coordinates":48},"Point",[49,50],7.44744,46.94809,{"lat":50,"lon":49},[53],{"name":30,"role":35,"phone":11,"phoneExt":11,"email":11},{"facility":55,"status":56,"city":57,"state":11,"zip":58,"country":44,"countryCode":45,"cosmosGeoPoint":59,"geoPoint":63,"contacts":64},"Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich","NOT_YET_RECRUITING","Zurich","8091",{"type":47,"coordinates":60},[61,62],8.55,47.36667,{"lat":62,"lon":61},[65],{"name":66,"role":35,"phone":67,"phoneExt":11,"email":68},"Laura Horka, MD","+41 44 255 36 20","laura.horka@usz.ch",{"type":70,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[72,74,76,78],{"name":73,"class":6},"University of Zurich",{"name":75,"class":6},"University Hospital Freiburg",{"name":77,"class":6},"University Hospital Heidelberg",{"name":79,"class":6},"Medical University Innsbruck","100581615","dietary-treatment-strategies-and-metabolic-control-in-glycogen-storage-disease-type-i-100581615",false,"NCT06852612","Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I","Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I (GSD-DIET)","GSD-DIET","Inclusion Criteria:\n\n* Genetically and\u002For enzymatically confirmed diagnosis of GSDI (GSDIa or GSDIb)\n* Male or female ≥ 18y\n* Restriction of fructose intake in usual dietary treatment\n* Written informed consent\n\nExclusion Criteria:\n\n* Non-compliance with routine dietary treatment\n* Pregnancy or lactation\n* Liver transplant\n* Recurrent hospitalisations due to metabolic decompensation within the last 12 months\n* Severe chronic kidney disease with glomerular filtration rate (GFR) \\\u003C 30 ml\u002Fmin\n* For GSDIb: Severe, uncontrolled symptomatic inflammatory bowel disease","ALL","18 Years",{"count":91,"type":92},20,"ESTIMATED","INTERVENTIONAL",[95],"NA","The present project will specifically assess metabolic effects of dietary interventions with controlled intake of fructose and fructose\u002Fgalactose in GSDI, with the aim to provide evidence whether relaxed dietary restrictions of fructose and galactose may be justified in treatment recommendations at least for adults, which would considerably enlarge food choice in everyday life of the patients with an expected positive impact on the quality of life of patients with this rare disorder.",[98],"Glycogen Storage Disease Type I",[100,101,21,102],"Gsd1","Metabolism","Galactose","2026-05-07",{"date":105,"type":106},"2026-05-12","ACTUAL",{"date":108,"type":106},"2025-04-24",{"date":110,"type":92},"2027-03",{"name":5,"class":6},2]