[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633416":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":40,"centralContacts":53,"locations":59,"responsibleParty":77,"collaborators":40,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":40,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":40,"overallStatus":102,"whyStopped":40,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Sinop University","OTHER",[8,14,20,25,30],{"label":9,"type":10,"description":11,"interventionNames":12},"Sham taVNS","SHAM_COMPARATOR","Participants receive sham stimulation during one study session.",[13],"Device: Sham taVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"taVNS 10 Hz","EXPERIMENTAL","Participants receive active transcutaneous auricular vagus nerve stimulation at 10 Hz during one study session.",[19],"Device: taVNS 10 Hz",{"label":21,"type":16,"description":22,"interventionNames":23},"taVNS 25 Hz","Participants receive active transcutaneous auricular vagus nerve stimulation at 25 Hz during one study session.",[24],"Device: taVNS 25 Hz",{"label":26,"type":16,"description":27,"interventionNames":28},"taVNS 50 Hz","Participants receive active transcutaneous auricular vagus nerve stimulation at 50 Hz during one study session.",[29],"Device: taVNS 50 Hz",{"label":31,"type":16,"description":32,"interventionNames":33},"taVNS 100 Hz","Participants receive active transcutaneous auricular vagus nerve stimulation at 100 Hz during one study session.",[34],"Device: taVNS 100 Hz",[36,41,44,47,50],{"type":37,"name":9,"description":38,"armGroupLabels":39,"otherNames":40},"DEVICE","Sham stimulation is delivered under conditions similar to active taVNS without meaningful vagal stimulation.",[9],null,{"type":37,"name":15,"description":42,"armGroupLabels":43,"otherNames":40},"Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 10 Hz.",[15],{"type":37,"name":21,"description":45,"armGroupLabels":46,"otherNames":40},"Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 25 Hz.",[21],{"type":37,"name":26,"description":48,"armGroupLabels":49,"otherNames":40},"Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 50 Hz.",[26],{"type":37,"name":31,"description":51,"armGroupLabels":52,"otherNames":40},"Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 100 Hz.",[31],[54],{"name":55,"role":56,"phone":57,"phoneExt":40,"email":58},"Sefa Haktan Hatık, MSc, PhD","CONTACT","90 368 271 55 28","haktanhtk@gmail.com",[60],{"facility":61,"status":40,"city":62,"state":40,"zip":40,"country":63,"countryCode":40,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Artvin Coruh University, Artvin Vocational School, Disabled Care and Rehabilitation Laboratory","Artvin","Turkey (Türkiye)",{"type":65,"coordinates":66},"Point",[67,68],41.82172,41.18161,{"lat":68,"lon":67},[71,75],{"name":72,"role":56,"phone":73,"phoneExt":40,"email":74},"Ömer Dicle Kızıl, PT, MSc","+90 541523 36 91","omerdiclekizil@gmail.com",{"name":72,"role":76,"phone":40,"phoneExt":40,"email":40},"SUB_INVESTIGATOR",{"type":78,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":40,"oldOrganization":40},"PRINCIPAL_INVESTIGATOR","SEFA HAKTAN HATIK","Assistant Professor","100633416","different-frequency-applications-of-transcutaneous-auricular-vagus-nerve-stimulation-in-healthy-individuals-100633416",false,"NCT07526402","Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals","Investigation of the Acute Effects of Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation on Autonomic Physiological Responses in Healthy Individuals","taVNS-FREQ","Inclusion Criteria:\n\n* Healthy adults aged 18 to 40 years\n* No known neurological, cardiovascular, respiratory, or metabolic disease\n* Able to understand study procedures and provide written informed consent\n* No active infection, open wound, or dermatological lesion in the ear region that would interfere with taVNS application\n* Willing and able to attend all study visits\n\nExclusion Criteria:\n\n* History of cardiac arrhythmia, pacemaker, or any implanted electronic medical device History of hypertension, diabetes, chronic pulmonary disease, epilepsy, or systemic disease affecting autonomic nervous system function\n* Regular use of medications that may affect autonomic function (e.g., beta-blockers, antidepressants, antiarrhythmics)\n* Intense physical exercise within the previous 24 hours\n* High caffeine or alcohol intake within 12 hours prior to assessment\n* Active smoking on the assessment day\n* Pregnancy or suspected pregnancy\n* Severe discomfort during stimulation (VAS \\>= 7), dizziness, nausea, or unwillingness to continue\n* Any condition judged by the investigators to make participation unsuitable'",true,"ALL","18 Years","40 Years",{"count":94,"type":95},36,"ESTIMATED","INTERVENTIONAL",[98],"NA","This randomized, participant-blinded, sham-controlled crossover study aims to investigate the acute effects of different frequency applications of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic physiological responses in healthy adults. Participants will receive sham (0 Hz), 10 Hz, 25 Hz, 50 Hz, and 100 Hz taVNS in separate sessions with washout periods between visits. Heart rate variability, blood pressure, pulse rate, respiratory rate, and subjective discomfort will be assessed before and after each intervention session.",[101],"Healthy Volunteers","NOT_YET_RECRUITING","2026-04-13",{"date":105,"type":106},"2026-04-16","ACTUAL",{"date":108,"type":95},"2026-05-01",{"date":110,"type":95},"2026-09-01",{"name":5,"class":6},1]