[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100503328":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":33,"locations":38,"responsibleParty":63,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":10,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Universität Münster","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"on-pump coronary artery bypass graft surgery",null,"Due to the observational design of the study, no study-specific interventions are performed. Except for the above mentioned laboratory analyses, the treatment of the patients is completely guided by the responsible ICU physicians.\n\nStudy participation does not influence the determination of surgical procedure (on- vs off-pump).",[13],"Procedure: on-pump surgery",{"label":15,"type":10,"description":11,"interventionNames":16},"off-pump coronary artery bypass graft surgery",[17],"Procedure: off-pump surgery",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","on-pump surgery","the surgery will be performed \"on-pump\"",[9],{"type":20,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"off-pump surgery","the surgery will be performed \"off-pump\"",[15],[29],{"name":30,"affiliation":31,"role":32},"Alexander Zarbock, MD","University Hospital Muenster, Dept. of Anesthesiology, Intensive Care Therapy and Pain Medicine","STUDY_CHAIR",[34],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+492518347255","aki@anit.uni-muenster.de",[39,52],{"facility":40,"status":41,"city":42,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":10},"Deutsches Herzzentrum der Charité","RECRUITING","Berlin","13353","Germany","DE",{"type":47,"coordinates":48},"Point",[49,50],13.41053,52.52437,{"lat":50,"lon":49},{"facility":53,"status":41,"city":54,"state":10,"zip":55,"country":44,"countryCode":45,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain Medicine","Münster","48149",{"type":47,"coordinates":57},[58,59],7.62571,51.96236,{"lat":59,"lon":58},[62],{"name":30,"role":35,"phone":10,"phoneExt":10,"email":10},{"type":64,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100503328","differential-regulation-of-raas-axis-in-patients-undergoing-cardiac-surgery-100503328",false,"NCT05833828","Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery","Differences in Plasma Concentration of RAAS-axis Hormones in Patients Undergoing Cardiac Surgery With or Without Cardiopulmonary Bypass","RAAS-HLM","Inclusion Criteria:\n\n1. adult patients undergoing on- or off-pump coronary artery bypass graft surgery\n2. written informed consent\n\nExclusion Criteria:\n\n1. emergency surgery in the context of acute coronary syndrome\n2. ACE-inhibitor or Angiotensin 1 (AT1)-receptor-blocker intake that was not paused on the day of surgery\n3. Chronic kidney disease with estimated glomerular filtration rate (eGFR)\\\u003C30ml\u002Fmin\u002F1.73m²\n4. Severe structural lung disease (asbestosis, silicosis, severe sarcoidosis, tuberculosis, severe emphysema, chronic obstructive pulmonary disease (COPD) Gold 3-4, lung fibrosis)\n5. Chronic pulmonary hypertension\n6. Pregnancy or breastfeeding\n7. Persons with any kind of dependency on the investigator or employed by the institution responsible or investigator\n8. Persons held in an institution by legal or official order","ALL","18 Years",{"count":76,"type":77},40,"ESTIMATED","OBSERVATIONAL","This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery",[81,82],"Vasoplegia","Vasoplegic Shock",[84,85,86,87],"vasoplegia","vasoplegic shock","cardiopulmonary bypass","cardiac surgery","2024-12-06",{"date":90,"type":91},"2024-12-12","ACTUAL",{"date":93,"type":91},"2023-08-24",{"date":95,"type":77},"2025-08",{"name":5,"class":6},2]