[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570268":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":33,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Shanghai Zhongshan Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"pituitary tumors in cavernous sinus group",null,"The 20 pituitary tumor samples in this group were obtained from the cavernous sinus region removed during surgery and were paired with pituitary tumors in the intralellar region",[13],"Other: surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"pituitary tumors in sellar group","The 20 pituitary tumors in this group were obtained from intrasellar samples removed during surgery and were paired with pituitary tumors in the cavernous sinus region",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"surgery","Samples were obtained from patients by surgical excision and matched into groups",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Tao Xie","Fudan University","STUDY_DIRECTOR",[29],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","+8613524281211","xie.tao@zs-hospital.sh.cn",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Zhongshan Hospital Fudan University","RECRUITING","Shanghai","Shanghai Municipality","200032","China","CN",{"type":43,"coordinates":44},"Point",[45,46],121.45806,31.22222,{"lat":46,"lon":45},[49],{"name":25,"role":30,"phone":10,"phoneExt":10,"email":10},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100570268","differential-study-of-invasive-pituitary-adenomas-in-the-sellar-and-cavernous-sinus-regions-100570268",false,"NCT06705036","Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions","Inclusion Criteria:\n\n1. Invasive pituitary tumors involving the cavernous sinus\n2. Retrospective inclusion of patients who have signed informed consent forms for the donation of biological samples and health-related information\n3. Age range: 18-80 years\n4. Subjects are willing to participate in this study\n\nExclusion Criteria:\n\n1. Non-invasive pituitary tumors\n2. Pregnant or breastfeeding\n3. Other conditions deemed unsuitable for participation in this clinical trial as assessed by the physician","ALL","18 Years","80 Years",{"count":62,"type":63},20,"ESTIMATED","OBSERVATIONAL","This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis. Proteomics and transcriptomics are employed to identify molecular differences, while imaging data (MRI\u002FCT) assesses tumor morphology and invasion. In vitro experiments and mechanistic studies validate key findings, exploring how regional molecular differences affect tumor behavior. Data integration combines multi-omics and imaging features to uncover biomarkers and pathways associated with invasiveness and regional specificity, with statistical analysis ensuring significance and reliability.",[67],"Pituitary Tumor",[69,70],"cavernous sinus","intrasellar","2024-11-23",{"date":73,"type":74},"2024-11-26","ACTUAL",{"date":76,"type":74},"2024-11-01",{"date":78,"type":63},"2026-12-31",{"name":5,"class":6},1]