[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619185":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":42,"collaborators":44,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Nova Southeastern University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"People diagnosed with ALS",null,"This group will be the group of 30 (anticipated) participants diagnosed with ALS.",{"label":13,"type":10,"description":14,"interventionNames":10},"Age and Gender matched control group","This group is the group of 5 (anticipated) control adults not diagnoses with ALS.",[16],{"name":17,"affiliation":5,"role":18},"Lauren Tabor Gray, Ph.D CCC-SLP","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Vanessa Navarrete, B.S","CONTACT","(954)857-5346","vnavarre@nova.edu",{"name":26,"role":22,"phone":10,"phoneExt":10,"email":27},"Eden Pressley, B.S","ep1200@nova.edu",[29],{"facility":30,"status":10,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":10},"Cathy J Husman ALS Center at Nova Southeastern University","Fort Lauderdale","Florida","33314","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-80.14338,26.12231,{"lat":40,"lon":39},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45],{"name":46,"class":6},"Peter Cohen Foundation (PCF)","100619185","digital-speech-markers-for-monitoring-als-in-spanish-speakers-100619185",false,"NCT07341334","Digital Speech Markers for Monitoring ALS in Spanish Speakers","Developing Digital Speech Biomarkers of Bulbar Disease Decline in Spanish-Speaking Persons With Amyotrophic Lateral Sclerosis","Inclusion Criteria:\n\n* diagnosis of definite ALS\n* monolingual or first language Spanish speaker\n* literate in Spanish\n* ALS Functional Rating Scale speech score of ≧2\n\nExclusion Criteria:\n\n* no diagnosis of concomitant respiratory disease such as COPD, emphysema, or current TOB use.",true,"ALL","18 Years","90 Years",{"count":59,"type":60},35,"ESTIMATED","4 Years","OBSERVATIONAL","The goal of this observational study is to learn how speech and breathing change over time in Spanish-speaking individuals with amyotrophic lateral sclerosis (ALS) compared to age- and gender-matched individuals without ALS.\n\nThe main questions it aims to answer are:\n\nCan speech and breathing measures collected through a smartphone application serve as reliable digital biomarkers to track bulbar disease decline in Spanish-speaking people with ALS?\n\nHow do these measures differ between individuals with ALS and those without ALS?\n\nResearchers will compare Spanish-speaking participants with ALS to age- and gender-matched healthy controls to see if specific speech and breathing features can identify or predict bulbar decline.\n\nParticipants will:\n\nUse a Spanish-language smartphone application to record speech and breathing tasks over time.\n\nComplete assessments of speech, breathing, and functional abilities (e.g., ALS Functional Rating Scale).\n\nProvide data that will be compared to caregiver reports and clinical outcomes to validate new digital biomarkers.",[65,66,67],"Amyotrophic Lateral Sclerosis","Lou Gehrig's Disease","ALS",[69,70,71,67],"speech biomarkers","amyotrophic lateral sclerosis","Lou Gehrig's disease","NOT_YET_RECRUITING","2026-02-23",{"date":75,"type":76},"2026-02-25","ACTUAL",{"date":78,"type":60},"2026-04",{"date":80,"type":60},"2029-12",{"name":5,"class":6},1]