[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627479":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":37,"centralContacts":38,"locations":37,"responsibleParty":47,"collaborators":37,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":37,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":37,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":78,"whyStopped":37,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":37},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A - Diode Laser + CPP-ACPF","EXPERIMENTAL","Participants will receive diode laser treatment combined with CPP-ACPF varnish on sensitive teeth.",[13],"Device: Diode laser photobiomodulation combined with CPP-ACPF varnish",{"label":15,"type":16,"description":17,"interventionNames":18},"Group B - CPP-ACPF Varnish Alone","ACTIVE_COMPARATOR","Participants will receive CPP-ACPF varnish alone on sensitive teeth.",[19],"Other: CPP-ACPF varnish",[21,31],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Diode laser photobiomodulation combined with CPP-ACPF varnish","Participants will receive diode laser photobiomodulation applied to sensitive teeth followed by application of CPP-ACPF varnish according to the manufacturer's instructions. This combination treatment is intended to reduce dentin hypersensitivity.",[9],[27,28,29,30],"Diode laser therapy","Low-level laser therapy (LLLT)","photobiomodulation","PBM",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"CPP-ACPF varnish","Participants will receive CPP-ACPF varnish applied to sensitive teeth according to the manufacturer's instructions to reduce dentin hypersensitivity.",[15],[36],"Casein phosphopeptide-amorphous calcium phosphate fluoride varnish",null,[39,44],{"name":40,"role":41,"phone":42,"phoneExt":37,"email":43},"Mariam M Mohamed, Master's candidate","CONTACT","+20 100 088 2942","mariam.kamal@dentistry.cu.edu.eg",{"name":45,"role":41,"phone":37,"phoneExt":37,"email":46},"Mona M Eissa","monamahmoud@dentistry.cu.edu.eg",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"PRINCIPAL_INVESTIGATOR","Mariam Mamdouh Mohamed Kamal","Dentist","100627479","diode-laser-plus-cpp-acpf-vs-cpp-acpf-alone-for-dentin-hypersensitivity-100627479",false,"NCT07449169","Diode Laser Plus CPP-ACPF vs CPP-ACPF Alone for Dentin Hypersensitivity","Comparative Efficacy of Diode Laser Photobiomodulation Combined With CPP-ACPF Varnish Versus CPP-ACPF Varnish Alone in the Management of Dentin Hypersensitivity: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult participants aged from 20 to 50 years of age.\n* Participants with good oral hygiene.\n* Presence of at least one tooth with dentin hypersensitivity confirmed by the air blast and\u002For tactile stimuli (scoring ≥3 on the VAS).\n* Participants willing to cooperate and attend recall appointments\n* Teeth with Non-Carious Cervical Lesions.\n* Patients with dentin hypersensitivity due to GERD and Parafunctional habits e.g., bruxism.\n* Patients with dentin hypersensitivity associated with gingival recession.\n\nExclusion Criteria:\n\n* Participants with poor oral hygiene.\n* History of professional or at-home desensitizing treatment within the previous 3 months.\n* Pregnant or lactating females.\n* Concurrent participation in other research studies.\n* Inability to comply with study procedures.\n* History of allergic reactions to study materials.\n* Medical conditions interfering with pain reporting accuracy (pain disorders, constant use of analgesics, anti-inflammatory, or psychotropic medications).\n* History of periodontal surgeries within the last six months.\n* Periodontitis and pulpitis.","ALL","20 Years","50 Years",{"count":62,"type":63},70,"ESTIMATED","INTERVENTIONAL",[66],"NA","This study aims to compare the effectiveness of diode laser photobiomodulation combined with CPP-ACPF varnish versus CPP-ACPF varnish alone in reducing dentin hypersensitivity. Participants diagnosed with dentin hypersensitivity will receive either the combined treatment or varnish application alone. Pain levels will be evaluated using a standardized visual analog scale before and after treatment sessions. The results of this study may help determine whether adding diode laser therapy enhances the effectiveness of conventional varnish treatment in managing dentin hypersensitivity.",[69,70],"Dentin Hypersensitivity","Tooth Hypersensitivity",[72,73,74,32,75,76,77,29],"dentin hypersensitivity","tooth hypersensitivity","diode laser","Dental laser treatment","Non-carious cervical lesions","Desensitizing treatment","NOT_YET_RECRUITING","2026-02-27",{"date":81,"type":82},"2026-03-04","ACTUAL",{"date":84,"type":63},"2026-04-01",{"date":86,"type":63},"2027-10-01",{"name":5,"class":6}]