[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610653":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":45,"responsibleParty":270,"collaborators":272,"id":276,"slug":277,"hasResults":278,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":278,"sex":284,"minAge":285,"maxAge":34,"enrollmentInfo":286,"targetDuration":34,"studyType":289,"phases":290,"briefSummary":292,"conditions":293,"keywords":295,"overallStatus":298,"whyStopped":34,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":308},{"fullName":5,"class":6},"Changhai Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Direct Visualization ERAT","EXPERIMENTAL","Undergo direct visualization endoscopic retrograde appendicitis therapy",[13],"Procedure: Direct Visualization Endoscopic Retrograde Appendicitis Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Laparoscopic Appendectomy","ACTIVE_COMPARATOR","Undergo laparoscopic appendectomy",[19],"Procedure: Laparoscopic appendectomy",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Direct Visualization Endoscopic Retrograde Appendicitis Therapy","Direct visualization ERAT will be performed by experienced endoscopists (≥ 30 prior ERAT cases) under conscious sedation or general anesthesia as needed. A colonoscope with a transparent cap will be advanced to the cecum to expose the appendiceal orifice, and a direct visualization appendicoscope will be introduced through the working channel. The appendiceal lumen will be inspected and irrigated with saline to clear pus and debris, with negative pressure applied for aspiration. Small appendicoliths will be flushed out, while larger ones will be removed using a retrieval basket, stone extractor, or laser lithotripsy. When narrowing or heavy purulence is present, a stent will be inserted for drainage. After confirming adequate drainage, the scope will be withdrawn. If ERAT fails, conversion to laparoscopic or open appendectomy will be performed.",[9],[27],"ERAT",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Laparoscopic appendectomy","Laparoscopic appendectomy will be performed under general anesthesia by surgeons with experience in \\> 20 procedures, according to standard clinical practice. The resected appendix will be examined for gross features and sent for histopathological confirmation of acute uncomplicated appendicitis. If laparoscopic appendectomy is unsuccessful, conversion to open appendectomy will be performed.",[15],[33],"LA",null,[36,41],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Zhuan Liao, MD, PhD","CONTACT","021-81873001","liaozhuan@smmu.edu.cn",{"name":42,"role":38,"phone":43,"phoneExt":34,"email":44},"Saif Ullah, MD, PhD","008615538100231","saif_ullah@zzu.edu.cn",[46,67,81,96,112,131,147,160,176,192,212,228,244,258],{"facility":47,"status":34,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University","Chongqing","Chingqing","400010","China","CN",{"type":54,"coordinates":55},"Point",[56,57],106.55771,29.56026,{"lat":57,"lon":56},[60,64],{"name":61,"role":38,"phone":62,"phoneExt":34,"email":63},"Song He, MD, PhD","13808336120","hedoctor65@cqmu.edu.cn",{"name":65,"role":66,"phone":34,"phoneExt":34,"email":34},"Song he, MD, PhD","PRINCIPAL_INVESTIGATOR",{"facility":68,"status":34,"city":69,"state":70,"zip":71,"country":51,"countryCode":52,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University","Guangzhou","Guangdong","510655",{"type":54,"coordinates":73},[74,75],113.25,23.11667,{"lat":75,"lon":74},[78,80],{"name":79,"role":38,"phone":34,"phoneExt":34,"email":34},"Zhen He, MD, PhD",{"name":79,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":82,"status":34,"city":83,"state":70,"zip":84,"country":51,"countryCode":52,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University","Shenzhen","518116",{"type":54,"coordinates":86},[87,88],114.0683,22.54554,{"lat":88,"lon":87},[91,95],{"name":92,"role":38,"phone":93,"phoneExt":34,"email":94},"Si-Lin Huang, MD, PhD","13512756686","silinhuang@szu.edu.cn",{"name":92,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":97,"status":34,"city":98,"state":99,"zip":100,"country":51,"countryCode":52,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Department of Gastroenterology, The First Affiliated Hospital of Henan University,","Kaifeng","Henan","475001",{"type":54,"coordinates":102},[103,104],114.30742,34.7986,{"lat":104,"lon":103},[107,111],{"name":108,"role":38,"phone":109,"phoneExt":34,"email":110},"Wen-Yi Yang, MD, PhD","008615890922163","baoca4621210@163.com",{"name":108,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":113,"status":34,"city":114,"state":99,"zip":115,"country":51,"countryCode":52,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University","Zhengzhou","450000",{"type":54,"coordinates":117},[118,119],113.64861,34.75778,{"lat":119,"lon":118},[122,126,130],{"name":123,"role":38,"phone":124,"phoneExt":34,"email":125},"Bing-Rong Liu, MD, PhD","008613313695959","fccliubr@zzu.edu.cn",{"name":127,"role":38,"phone":128,"phoneExt":34,"email":129},"Dan Liu, MD, PhD","0086183 3980 0019","wilmawell@163.com",{"name":123,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":132,"status":34,"city":133,"state":134,"zip":135,"country":51,"countryCode":52,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"Department of Gastrointestinal Surgery, Hunan Provincial People's Hospital","Changsha","Hunan","410005",{"type":54,"coordinates":137},[138,139],112.97087,28.19874,{"lat":139,"lon":138},[142,146],{"name":143,"role":38,"phone":144,"phoneExt":34,"email":145},"Chao-Wu Chen, MD, PhD","008613298682898","dr.chencw@hunnu.edu.cn",{"name":143,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":148,"status":34,"city":133,"state":134,"zip":149,"country":51,"countryCode":52,"cosmosGeoPoint":150,"geoPoint":152,"contacts":153},"Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University","410008",{"type":54,"coordinates":151},[138,139],{"lat":139,"lon":138},[154,158],{"name":155,"role":38,"phone":156,"phoneExt":34,"email":157},"Wei-Dong Liu, MD, PhD","008613873124855","davidcsu@foxmail.com",{"name":159,"role":66,"phone":34,"phoneExt":34,"email":34},"Weo-Dong iu, MD, PhD",{"facility":161,"status":34,"city":162,"state":163,"zip":164,"country":51,"countryCode":52,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Soochow University","Suzhou","Jiangsu","215008",{"type":54,"coordinates":166},[167,168],120.59538,31.30408,{"lat":168,"lon":167},[171,175],{"name":172,"role":38,"phone":173,"phoneExt":34,"email":174},"Yong-You Wu, MD, PhD","008613338706607","wuyongyou72@126.com",{"name":172,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":177,"status":34,"city":178,"state":179,"zip":180,"country":51,"countryCode":52,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Department of Gastroenterology, The First Affiliated Hospital of Nanchang University","Nanchang","Jiangxi","330006",{"type":54,"coordinates":182},[183,184],115.85306,28.68396,{"lat":184,"lon":183},[187,191],{"name":188,"role":38,"phone":189,"phoneExt":34,"email":190},"Yin Zhu, MD, PhD","008613970841464","zhuyin27@sina.com",{"name":188,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":193,"status":34,"city":194,"state":195,"zip":196,"country":51,"countryCode":52,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Department of Gastroenterology, Jilin City People's Hospital","Jilin City","Jilin","132011",{"type":54,"coordinates":198},[199,200],126.5608,43.84652,{"lat":200,"lon":199},[203,207,211],{"name":204,"role":38,"phone":205,"phoneExt":34,"email":206},"Hong-Guang Wang, MD, PhD","008618904421817","wanghongguang1817@163.com",{"name":208,"role":38,"phone":209,"phoneExt":34,"email":210},"Liying Tao, MD, PhD","13689866436","406346148@qq.com",{"name":204,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":213,"status":34,"city":214,"state":215,"zip":216,"country":51,"countryCode":52,"cosmosGeoPoint":217,"geoPoint":221,"contacts":222},"Department of Gastroenterology, Linyi People's Hospital","Linyi","Shandong","276000",{"type":54,"coordinates":218},[219,220],118.34278,35.06306,{"lat":220,"lon":219},[223,227],{"name":224,"role":38,"phone":225,"phoneExt":34,"email":226},"Ling-Jian Kong, MD, PhD","0086157 1369 8818","konggewww@163.com",{"name":224,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":229,"status":34,"city":230,"state":231,"zip":232,"country":51,"countryCode":52,"cosmosGeoPoint":233,"geoPoint":237,"contacts":238},"Department of Gastrointestinal Surgery, Fourth West China Hospital, Sichuan University","Chengdu","Sichuan","610041",{"type":54,"coordinates":234},[235,236],104.06667,30.66667,{"lat":236,"lon":235},[239,243],{"name":240,"role":38,"phone":241,"phoneExt":34,"email":242},"Juan Liao, MD, PhD","00618780267956","juanliao@scu.edu.cn",{"name":240,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":245,"status":34,"city":246,"state":34,"zip":34,"country":51,"countryCode":52,"cosmosGeoPoint":247,"geoPoint":251,"contacts":252},"Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine","Hangzhou",{"type":54,"coordinates":248},[249,250],120.16142,30.29365,{"lat":250,"lon":249},[253,257],{"name":254,"role":38,"phone":255,"phoneExt":34,"email":256},"Ji-Chao Qin, MD, PhD","008613628683363","jcqin2024@zju.edu.cn",{"name":254,"role":66,"phone":34,"phoneExt":34,"email":34},{"facility":259,"status":34,"city":260,"state":34,"zip":261,"country":51,"countryCode":52,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"Department of Gastroenterology, Changhai Hospital, Naval Medical University","Shanghai","200433",{"type":54,"coordinates":263},[264,265],121.45806,31.22222,{"lat":265,"lon":264},[268,269],{"name":37,"role":38,"phone":34,"phoneExt":34,"email":40},{"name":37,"role":66,"phone":34,"phoneExt":34,"email":34},{"type":66,"investigatorFullName":271,"investigatorTitle":271,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"Zhuan Liao",[273],{"name":274,"class":275},"Micro-Tech (Nanjing) Co., Ltd.","INDUSTRY","100610653","direct-visualization-erat-versus-laparoscopic-appendectomy-in-adults-with-acute-uncomplicated-appendicitis-100610653",false,"NCT07230379","Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis","Direct Visualization Endoscopic Retrograde Appendicitis Therapy (ERAT) Versus Laparoscopic Appendectomy (LA) for Acute Uncomplicated Appendicitis in Adults (E-APPEND): An Open-Label, Multicenter, Randomized Controlled Non-Inferiority Trial","E-APPEND","Inclusion Criteria:\n\n1. Age ≥ 18 years.\n2. Diagnosis of first-episode acute uncomplicated appendicitis (AUA) confirmed by CT scan of the lower abdomen. AUA is defined as acute appendicitis without evidence of abscess, perforation, gangrene, or tumor.\n3. Provision of written informed consent.\n\nExclusion Criteria:\n\n1. Complicated appendicitis, defined as acute appendicitis with perforation, gangrene, periappendiceal abscess or phlegmon, generalized peritonitis, or radiologic evidence of extraluminal appendicolith, extraluminal air, periappendiceal fat stranding, or appendiceal mass.\n2. Severe intestinal adhesions or bowel obstruction.\n3. Intolerance or contraindication to bowel preparation or colonoscopy (e.g., intestinal perforation or bowel obstruction).\n4. Poor general condition precluding tolerance of abdominal surgery.\n5. Abdominal pain caused by other diseases as confirmed by CT or other diagnostic examinations, including inflammatory bowel disease, urinary tract disease, or gynecological disease.\n6. Pregnancy.\n7. Severe dysfunction of major organ systems, including but not limited to cardiac, pulmonary, renal, hepatic, or hematologic systems.\n8. Current enrollment in another clinical trial.\n9. Any condition that may prevent the participant from completing all study requirements.","ALL","18 Years",{"count":287,"type":288},376,"ESTIMATED","INTERVENTIONAL",[291],"NA","This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT). This is a minimally invasive, non-surgical treatment that uses a flexible endoscope passed through the colon to reach the appendix, clear the blockage, and drain the infection. In the Surgery group, participants will undergo Laparoscopic Appendectomy (LA), which is the current standard surgical treatment to remove the appendix. The purpose of this study is to determine whether ERAT is as safe and effective as standard surgery for treating uncomplicated appendicitis.\n\nBefore treatment, each participant will have a CT scan of the lower abdomen with contrast to confirm uncomplicated appendicitis and to rule out any signs of more serious infection. Participants will then be randomly assigned to either the ERAT group or the surgery group, and they will be informed of which treatment they will receive. Regardless of the group, all participants will receive the same supportive care, including pain relief, close monitoring, and a single dose of antibiotics before treatment. After the procedure, participants will stay in the hospital for at least 24 hours for observation. Follow-up will include an outpatient visit at 2 weeks, and telephone follow-ups at 1 month, 3 months, 6 months, and 1 year to monitor recovery and ensure that appendicitis does not recur.",[294],"Acute Uncomplicated Appendicitis",[27,296,297,33,29],"Endoscopic retrograde appendicitis therapy","Appendicitis","NOT_YET_RECRUITING","2025-11-13",{"date":301,"type":302},"2025-11-17","ACTUAL",{"date":304,"type":288},"2025-11",{"date":306,"type":288},"2027-11",{"name":5,"class":6},14]