[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100541517":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":18,"collaborators":7,"id":21,"slug":22,"hasResults":23,"nctId":24,"briefTitle":25,"officialTitle":25,"acronym":26,"eligibilityCriteria":27,"healthyVolunteers":23,"sex":28,"minAge":29,"maxAge":7,"enrollmentInfo":30,"targetDuration":7,"studyType":33,"phases":7,"briefSummary":34,"conditions":35,"keywords":37,"overallStatus":43,"whyStopped":7,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":7},{"fullName":5,"class":6},"Siriraj Hospital","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Chutima Kunacheewa","CONTACT","66896790959","chutima.kua@mahidol.ac.th",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Weerapat Owattanapanich","66891081983","weerapat.owa@mahidol.ac.th",{"type":19,"investigatorFullName":10,"investigatorTitle":20,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","lecturer","100541517","disease-characteristics-and-treatment-response-in-plasma-cell-disorders-patients-based-on-genetic-abnormalities-from-fluorescence-in-situ-hybridization-and-next-generation-sequencing-100541517",false,"NCT06330896","Disease Characteristics and Treatment Response in Plasma Cell Disorders Patients Based on Genetic Abnormalities From Fluorescence In Situ Hybridization and Next Generation Sequencing","genetics MM","Inclusion Criteria:\n\n* Patients with Plasma Cell Disorders including MGUS, SMM, MM, and amyloidosis\n* Aged 18 years and older\n* Performed FISH and\u002For NGS testing\n* Has treatment follow up at least one year\n\nExclusion Criteria:\n\n* Patients with missing crucial data that renders them unanalyzable\n* Patients who refuse to participate in the study","ALL","18 Years",{"count":31,"type":32},498,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to study the genetic landscape in patients with Plasma Cell Disorders including MGUS, SMM, MM, and amyloidosis in Thailand. The main questions it aims to answer are:\n\n* genetic landscape in patients with Plasma Cell Disorders including MGUS, SMM, MM, and amyloidosis in Thailand who were performed FISH and\u002For NGS testing\n* genetic correlation and genetic dependency between FISH and NGS, stratified by high- and standard-risk groups based on FISH testing in Thai MM patients.\n* disease characteristics and response rates in MM patients with cytogenetic abnormalities detected by FISH and\u002For genetic mutations detected by NGS.\n* correlation between cytogenetic abnormalities identified by FISH and genetic mutations detected by NGS with progression-free survival in MM patients.\n\nThe FISH and\u002For NGS testing results, disease characteristics, treatment, and treatment outcomes of patients with plasma cell disorders who underwent FISH and\u002For NGS testing before IRB approval will be collected through retrospective chart review. Subsequently, data will be gathered prospectively. Participants will provide approximately 12 mL of bone marrow fluid for FISH and NGS testing.",[36],"Plasma Cell Disorder",[36,38,39,40,41,42],"genetic abnormalities","Fluorescence In Situ Hybridization","FISH","Next Generation Sequencing","NGS","NOT_YET_RECRUITING","2024-03-19",{"date":46,"type":47},"2024-03-26","ACTUAL",{"date":49,"type":32},"2024-04-01",{"date":51,"type":32},"2028-04-01",{"name":5,"class":6}]