[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609895":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":59,"collaborators":24,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":24,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"University of California, San Francisco","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HGNS 'Off' Case-Crossover Arm","EXPERIMENTAL","On a given day of the 14-day study period, participants may be randomly assigned to turn off\u002Fnot use their HGNS device during that night of sleep. Participants will not receive the same randomization assignment more than two consecutive days in a row.",[13],"Device: HGNS Use Randomized Instructions",{"label":15,"type":10,"description":16,"interventionNames":17},"HGNS 'On' Case-Crossover Arm","On a given day of the 14-day study period, participants may be randomly assigned to turn on\u002Fuse their HGNS device during that night of sleep. Participants will not receive the same randomization assignment more than two consecutive days in a row.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","HGNS Use Randomized Instructions","In this intervention assignment, participants will be instructed to turn off\u002Fnot use their HGNS device during that night of sleep. HGNS 'on': In this intervention assignment, participants will be instructed to turn on\u002Fuse their HGNS device during that night of sleep.",[9,15],null,[26],{"name":27,"affiliation":5,"role":28},"Gregory Marcus, MD, MAS","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Hannah Oo, BS","CONTACT","415-476-4999","hannah.oo@ucsf.edu",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":38},"Bella Peña, BA","415-502-3053","bella.pena@ucsf.edu",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"UCSF Medical Center at Parnassus","RECRUITING","San Francisco","California","94143","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-122.41942,37.77493,{"lat":52,"lon":51},[55,58],{"name":27,"role":32,"phone":56,"phoneExt":24,"email":57},"415-476-5706","greg.marcus@ucsf.edu",{"name":27,"role":28,"phone":24,"phoneExt":24,"email":24},{"type":60,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100609895","disrupted-sleep-and-concurrent-ectopy-or-atrial-fibrillation-100609895",false,"NCT07220525","Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation","DISCRETE AF","Inclusion Criteria:\n\n* Are age 21 years or older\n* Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health\n* Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Currently pregnant or trying to get pregnant\n* Are currently taking class 1 or 3 anti-arrhythmic medications\n* Have a history of permanent AF or expected to have continuous AF throughout the study period\n* Have congenital heart disease\n* Ventricular pacing \\>40%\n* Are unable to read or sign to provide informed consent","ALL","21 Years",{"count":71,"type":72},100,"ESTIMATED","INTERVENTIONAL",[75],"NA","Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.",[78,79,80,81],"Obstructive Sleep Apnea","Premature Ventricular Contraction (PVC)","Atrial Fibrillation (AF)","Premature Atrial Contraction",[83,84,85,86,81,87],"Sleep Apnea","Hypoglossal Nerve Stimulation Device","Atrial Fibrillation","Upper Airway Stimulation","Premature Ventricular Contraction","2026-01-21",{"date":90,"type":91},"2026-01-23","ACTUAL",{"date":93,"type":91},"2025-12-15",{"date":95,"type":72},"2027-06-01",{"name":5,"class":6},1]