[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508844":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":16,"centralContacts":21,"locations":30,"responsibleParty":47,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":7,"studyType":66,"phases":7,"briefSummary":67,"conditions":68,"keywords":7,"overallStatus":33,"whyStopped":7,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Electroencephalography (EEG)","High-density EEG will be acquired during resting wakefulness before each ECT session.",{"type":10,"name":14,"description":15,"armGroupLabels":7,"otherNames":7},"Quantitative Measurements of Sleep Microstructure","Overnight sleep EEG will be recorded one day before each ECT session using the DREEM device. The DREEM device allows continuous recording of multichannel EEG.",[17],{"name":18,"affiliation":19,"role":20},"MohammadMehdi Kafashan","Washington University School of Medicine in St. Louis","PRINCIPAL_INVESTIGATOR",[22,27],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},"Robby Greenspan","CONTACT","314-273-6129","greenspan@wustl.edu",{"name":18,"role":24,"phone":28,"phoneExt":7,"email":29},"314-273-8848","kafashan@wustl.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Washington University School of Medicine\u002FBarnes-Jewish Hospital","RECRUITING","St Louis","Missouri","63110","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-90.19789,38.62727,{"lat":43,"lon":42},[46],{"name":23,"role":24,"phone":25,"phoneExt":7,"email":26},{"type":20,"investigatorFullName":18,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Instructor",[50],{"name":51,"class":52},"National Institute of Mental Health (NIMH)","NIH","100508844","disruptions-of-brain-networks-and-sleep-by-electroconvulsive-therapy-100508844",false,"NCT05905705","Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy","DNS-ECT","Inclusion Criteria:\n\n* Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.\n\nExclusion Criteria:\n\n* Diagnoses of schizophrenia or schizoaffective disorders.\n* Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.","ALL","21 Years","65 Years",{"count":64,"type":65},50,"ESTIMATED","OBSERVATIONAL","Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.",[69],"Treatment Resistant Depression","2026-03-11",{"date":72,"type":73},"2026-03-12","ACTUAL",{"date":75,"type":73},"2023-03-07",{"date":77,"type":65},"2027-07-31",{"name":5,"class":6},1]