[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632657":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":34,"locations":41,"responsibleParty":54,"collaborators":33,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":33,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":33,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":90,"whyStopped":33,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"In-Scope Suction Group","EXPERIMENTAL","Participants assigned to this arm will undergo suction-assisted retrograde intrarenal surgery using direct in-scope suction. A single-use flexible ureteroscope with suction function will be used, and direct suction will be applied through the working channel during laser lithotripsy. Negative pressure will be maintained between 2 and 7 kilopascals and adjusted intraoperatively according to visibility and fragment evacuation. Laser lithotripsy will be performed using a holmium:yttrium-aluminum-garnet laser with dusting and popcorn techniques, followed by placement of a 6 French double-J ureteral stent.",[13],"Procedure: Direct In-Scope Suction",{"label":15,"type":10,"description":16,"interventionNames":17},"Flexible and Navigable Suction Ureteric Access Sheath Group","Participants assigned to this arm will undergo suction-assisted retrograde intrarenal surgery using a flexible and navigable suction ureteric access sheath. The sheath will be inserted under guidewire guidance and connected to a vacuum device. Negative pressure will be maintained between 2 and 7 kilopascals and adjusted intraoperatively according to visibility and fragment evacuation. Laser lithotripsy will be performed using a holmium:yttrium-aluminum-garnet laser with dusting and popcorn techniques. Suction will be applied intermittently through the sheath to facilitate fragment evacuation, followed by placement of a 6 French double-J ureteral stent.",[18],"Procedure: Flexible and Navigable Suction Ureteric Access Sheath",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Direct In-Scope Suction","Direct suction is applied through the working channel of the flexible ureteroscope during retrograde intrarenal surgery to facilitate evacuation of stone fragments and improve intraoperative visibility during laser lithotripsy.",[9],[26],"DISS",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Flexible and Navigable Suction Ureteric Access Sheath","A flexible and navigable suction ureteric access sheath is used during retrograde intrarenal surgery to provide suction-assisted evacuation of stone fragments, improve visibility, and support intrarenal pressure control during laser lithotripsy.",[15],[32],"FANS",null,[35],{"name":36,"role":37,"phone":38,"phoneExt":39,"email":40},"Ahmed S Marey, MBBCh","CONTACT","01550199333","+02","AhmedMarey@med.asu.edu.eg",[42],{"facility":43,"status":33,"city":44,"state":33,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":33},"Ain Shams University Hospitals","Cairo","11511","Egypt","EG",{"type":49,"coordinates":50},"Point",[51,52],31.24967,30.06263,{"lat":52,"lon":51},{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Ahmed Samy Abd Elmawgod Ali Marey","Resident of Urology","100632657","diss-vs-fans-in-suction-assisted-rirs-for-medium-sized-renal-stones-100632657",false,"NCT07516535","DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones","The Impact of Suction-Assisted RIRS (DISS Versus FANS) on Postoperative Infection Rate and Stone-Free Rate After Treatment of Medium Sized Renal Stones","Inclusion Criteria:\n\n* Adults aged 18 to 60 years\n* Radiologically confirmed renal stones measuring 2 to 3 centimeters\n* Eligible for retrograde intrarenal surgery\n* Normal renal function as evidenced by normal serum creatinine\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Active urinary tract infection at the time of enrollment\n* Bleeding disorders or coagulopathies that contraindicate surgical intervention\n* Anatomical malformations affecting the urinary tract\n* Solitary kidney\n* Inability or unwillingness to provide informed consent","ALL","18 Years","60 Years",{"count":69,"type":70},126,"ESTIMATED","INTERVENTIONAL",[73],"NA","Kidney stones are a common health problem and may recur frequently, which can affect quality of life and kidney function. Retrograde intrarenal surgery (RIRS) is a minimally invasive treatment used for renal stones, but treatment of medium-sized stones may be associated with longer operative time, impaired visibility during surgery, residual stone fragments, and postoperative infectious complications caused by increased intrarenal pressure.\n\nSuction-assisted retrograde intrarenal surgery (RIRS) techniques have been developed to improve surgical efficiency and safety by facilitating continuous removal of stone fragments and helping control intrarenal pressure. Two commonly used suction-assisted approaches are direct in-scope suction (DISS) and flexible and navigable suction ureteric access sheath (FANS). However, there is limited prospective randomized evidence directly comparing these two techniques.\n\nThis randomized prospective clinical study aims to compare direct in-scope suction (DISS) versus flexible and navigable suction ureteric access sheath (FANS) in adult patients with medium-sized renal stones measuring 2 to 3 cm who are undergoing retrograde intrarenal surgery (RIRS). Participants will be randomly assigned to one of the two suction-assisted techniques. The study will evaluate whether flexible and navigable suction ureteric access sheath (FANS) provides better outcomes than direct in-scope suction (DISS) in terms of stone-free rate and postoperative infection rate.\n\nThe primary outcome is stone-free status assessed by postoperative imaging. Secondary outcomes include operative time, intraoperative visibility, and postoperative complications, particularly infection and urosepsis. The study hypothesis is that suction-assisted retrograde intrarenal surgery (RIRS) using the flexible and navigable suction ureteric access sheath (FANS) technique will result in a higher stone-free rate and a lower postoperative infection rate compared with direct in-scope suction (DISS) in the management of medium-sized renal stones.",[76,77,78],"Kidney Stones","Nephrolithiasis","Renal Calculi",[80,81,82,83,84,85,86,87,88,89],"Retrograde Intrarenal Surgery","Suction-Assisted Retrograde Intrarenal Surgery","Medium-Sized Renal Stones","Stone-Free Rate","Postoperative Infection","Urosepsis","Flexible Ureteroscopy","Holmium Laser Lithotripsy","Ureteric Access Sheath","Intrarenal Pressure","NOT_YET_RECRUITING","2026-04-01",{"date":93,"type":94},"2026-04-08","ACTUAL",{"date":96,"type":70},"2026-04-30",{"date":98,"type":70},"2027-04-30",{"name":5,"class":6},1]