[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100302879":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":22,"locations":30,"responsibleParty":278,"collaborators":10,"id":281,"slug":282,"hasResults":283,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":283,"sex":288,"minAge":289,"maxAge":10,"enrollmentInfo":290,"targetDuration":293,"studyType":294,"phases":10,"briefSummary":295,"conditions":296,"keywords":299,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":311},{"fullName":5,"class":6},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"TIGER study cohort",null,"This is the entire patient cohort. Alle patients with resectable esophageal cancer undergoing a transthoracic esophagectomy with at least a 2-field lymphadenectomy",[13,16,19],{"name":14,"affiliation":5,"role":15},"Suzanne S Gisbertz, MD, PhD","STUDY_CHAIR",{"name":17,"affiliation":5,"role":18},"Mark I van Berge Henegouwen, MD, PHD","PRINCIPAL_INVESTIGATOR",{"name":20,"affiliation":5,"role":21},"Eliza RC Hagens, MD","STUDY_DIRECTOR",[23,27],{"name":14,"role":24,"phone":25,"phoneExt":10,"email":26},"CONTACT","+31205669111","s.s.gisbertz@amc.nl",{"name":28,"role":24,"phone":25,"phoneExt":10,"email":29},"Eliza RC Hagens, BSc","e.r.hagens@amc.uva.nl",[31,48,61,74,89,103,117,131,144,157,171,179,191,205,217,226,239,250,264],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"MD Anderson Cancer Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-95.36327,29.76328,{"lat":43,"lon":42},[46],{"name":47,"role":24,"phone":10,"phoneExt":10,"email":10},"W.L. Hofstetter, MD, PhD",{"facility":49,"status":33,"city":50,"state":10,"zip":10,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Instituto Nacional de Câncer","Rio de Janeiro","Brazil","BR",{"type":40,"coordinates":54},[55,56],-43.18223,-22.90642,{"lat":56,"lon":55},[59],{"name":60,"role":24,"phone":10,"phoneExt":10,"email":10},"C.E. Pinto, MD, PhD",{"facility":62,"status":33,"city":63,"state":10,"zip":10,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"University of Toronto","Toronto","Canada","CA",{"type":40,"coordinates":67},[68,69],-79.39864,43.70643,{"lat":69,"lon":68},[72],{"name":73,"role":24,"phone":10,"phoneExt":10,"email":10},"Gail Darling, MD PhD",{"facility":75,"status":33,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Fudan University Shanghai Cancer Center","Shanghai","Yangpu","200032","China","CN",{"type":40,"coordinates":82},[83,84],121.45806,31.22222,{"lat":84,"lon":83},[87],{"name":88,"role":24,"phone":10,"phoneExt":10,"email":10},"H. Chen, MD, PhD",{"facility":90,"status":33,"city":91,"state":10,"zip":92,"country":93,"countryCode":94,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Hospital District of Helsinki and Uusimaa","Helsinki","000260","Finland","FI",{"type":40,"coordinates":96},[97,98],24.93545,60.16952,{"lat":98,"lon":97},[101],{"name":102,"role":24,"phone":10,"phoneExt":10,"email":10},"J. Räsänen, MD, PhD",{"facility":104,"status":33,"city":105,"state":10,"zip":106,"country":107,"countryCode":108,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"University Medical Center of the Johannes Gutenberg University","Mainz","55131","Germany","DE",{"type":40,"coordinates":110},[111,112],8.28008,49.98185,{"lat":112,"lon":111},[115],{"name":116,"role":24,"phone":10,"phoneExt":10,"email":10},"P. Grimminger, MD, PhD",{"facility":118,"status":33,"city":119,"state":10,"zip":120,"country":121,"countryCode":122,"cosmosGeoPoint":123,"geoPoint":127,"contacts":128},"University of Athens, School of Medicine","Athens","11527","Greece","GR",{"type":40,"coordinates":124},[125,126],23.72784,37.98376,{"lat":126,"lon":125},[129],{"name":130,"role":24,"phone":10,"phoneExt":10,"email":10},"D. Theodorou, MD, PhD",{"facility":132,"status":33,"city":133,"state":10,"zip":134,"country":133,"countryCode":135,"cosmosGeoPoint":136,"geoPoint":140,"contacts":141},"University of Hong Kong","Hong Kong","102","HK",{"type":40,"coordinates":137},[138,139],114.17469,22.27832,{"lat":139,"lon":138},[142],{"name":143,"role":24,"phone":10,"phoneExt":10,"email":10},"S.Y.K Law, MD, PhD",{"facility":145,"status":33,"city":146,"state":10,"zip":10,"country":147,"countryCode":148,"cosmosGeoPoint":149,"geoPoint":153,"contacts":154},"Tata Memorial Centre","Mumbai","India","IN",{"type":40,"coordinates":150},[151,152],72.88261,19.07283,{"lat":152,"lon":151},[155],{"name":156,"role":24,"phone":10,"phoneExt":10,"email":10},"C.S. Pramesh, MD, PhD",{"facility":158,"status":33,"city":159,"state":10,"zip":160,"country":161,"countryCode":162,"cosmosGeoPoint":163,"geoPoint":167,"contacts":168},"IRCCS Policlinico San Donato","Milan","20097","Italy","IT",{"type":40,"coordinates":164},[165,166],9.18951,45.46427,{"lat":166,"lon":165},[169],{"name":170,"role":24,"phone":10,"phoneExt":10,"email":10},"L. Bonavina, MD, PhD",{"facility":172,"status":33,"city":159,"state":10,"zip":10,"country":161,"countryCode":162,"cosmosGeoPoint":173,"geoPoint":175,"contacts":176},"Ospedale San Raffaele",{"type":40,"coordinates":174},[165,166],{"lat":166,"lon":165},[177],{"name":178,"role":24,"phone":10,"phoneExt":10,"email":10},"Riccardo Rosati, MD",{"facility":180,"status":33,"city":181,"state":10,"zip":182,"country":161,"countryCode":162,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"University of Verona","Verona","37129",{"type":40,"coordinates":184},[185,186],10.9938,45.43854,{"lat":186,"lon":185},[189],{"name":190,"role":24,"phone":10,"phoneExt":10,"email":10},"G. de Manzoni, MD, PhD",{"facility":192,"status":33,"city":193,"state":10,"zip":194,"country":195,"countryCode":196,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Uonuma Institute and Niigata University","Niigata","9502292","Japan","JP",{"type":40,"coordinates":198},[199,200],139.04125,37.92259,{"lat":200,"lon":199},[203],{"name":204,"role":24,"phone":10,"phoneExt":10,"email":10},"S. Kosugi, MD, PhD",{"facility":206,"status":33,"city":207,"state":10,"zip":208,"country":195,"countryCode":196,"cosmosGeoPoint":209,"geoPoint":213,"contacts":214},"Keio University School of Medicine","Tokyo","1088345",{"type":40,"coordinates":210},[211,212],139.69171,35.6895,{"lat":212,"lon":211},[215],{"name":216,"role":24,"phone":10,"phoneExt":10,"email":10},"Y. Kitagawa, MD, PhD",{"facility":218,"status":33,"city":207,"state":10,"zip":219,"country":195,"countryCode":196,"cosmosGeoPoint":220,"geoPoint":222,"contacts":223},"The Cancer Institute Hospital of JFCR","1358550",{"type":40,"coordinates":221},[211,212],{"lat":212,"lon":211},[224],{"name":225,"role":24,"phone":10,"phoneExt":10,"email":10},"M. Watanabe, MD, PhD",{"facility":227,"status":33,"city":228,"state":10,"zip":10,"country":229,"countryCode":230,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Ziekenhuisgroep Twente, Almelo & Hengelo","Almelo","Netherlands","NL",{"type":40,"coordinates":232},[233,234],6.6625,52.35667,{"lat":234,"lon":233},[237],{"name":238,"role":24,"phone":10,"phoneExt":10,"email":10},"E. Kouwenhoven, MD, PhD",{"facility":240,"status":33,"city":241,"state":10,"zip":10,"country":229,"countryCode":230,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Amsterdam UMC","Amsterdam",{"type":40,"coordinates":243},[244,245],4.88969,52.37403,{"lat":245,"lon":244},[248],{"name":249,"role":24,"phone":10,"phoneExt":10,"email":10},"Suzanne S Gisbertz, MD PhD",{"facility":251,"status":33,"city":252,"state":10,"zip":253,"country":254,"countryCode":255,"cosmosGeoPoint":256,"geoPoint":260,"contacts":261},"Hospital Universitario del Mar","Barcelona","08003","Spain","ES",{"type":40,"coordinates":257},[258,259],2.15899,41.38879,{"lat":259,"lon":258},[262],{"name":263,"role":24,"phone":10,"phoneExt":10,"email":10},"M. Pera, MD, PhD",{"facility":265,"status":33,"city":266,"state":10,"zip":267,"country":268,"countryCode":269,"cosmosGeoPoint":270,"geoPoint":274,"contacts":275},"Karolinska Institutet","Stockholm","17177","Sweden","SE",{"type":40,"coordinates":271},[272,273],18.06871,59.32938,{"lat":273,"lon":272},[276],{"name":277,"role":24,"phone":10,"phoneExt":10,"email":10},"M. Nilsson, MD, PhD",{"type":18,"investigatorFullName":279,"investigatorTitle":280,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"S.S. Gisbertz","Upper GI Surgeon","100302879","distribution-of-lymph-node-metastases-in-esophageal-carcinoma-100302879",false,"NCT03222895","Distribution of Lymph Node Metastases in Esophageal Carcinoma","TIGER","Inclusion Criteria:\n\n* Primary squamous cell or adenocarcinoma of the esophagus or esophago-gastric junction\n* Surgically resectable (cT1-4a, N0-3, M0)\n* Adequate physical condition to undergo transthoracic surgery (ASA 1-3)\n* Transthoracic esophagectomy\n\nExclusion Criteria:\n\n* Previous thoracic or abdominal (upper GI) surgery disturbing lymph drainage of the esophagus and stomach\n* Patients with in situ carcinoma or high grade dysplasia","ALL","18 Years",{"count":291,"type":292},5000,"ESTIMATED","5 Years","OBSERVATIONAL","Background: Lymph node status is an important prognostic parameter in esophageal carcinoma and an independent predictor of survival. Distribution of metastatic lymph nodes may vary with tumor location, tumor histology, tumor invasion depth and neoadjuvant therapy. Surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy differs worldwide. Especially for adenocarcinoma the distribution of lymph node metastases has not yet been described in large series. Aim of the present study is to evaluate the distribution of lymph node metastases in esophageal carcinoma specimens following transthoracic esophagectomy with at least a 2-field lymphadenectomy.\n\nMethods: The TIGER-study is a multinational observational cohort study. All patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately sent for pathological examination. Cluster analysis will be performed to identify patterns of metastases in relation to tumor location, tumor histology, tumor invasion depth and neoadjuvant therapy.\n\nConclusion: TIGER will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed on the basis of these results, such as the the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics.",[297,298],"Esophageal Neoplasms","Lymph Node Metastases",[297,300,301],"Lymph node metastases","Esophagectomy","2024-02-12",{"date":304,"type":305},"2024-02-13","ACTUAL",{"date":307,"type":305},"2019-03-01",{"date":309,"type":292},"2028-06-01",{"name":5,"class":6},19]