[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584721":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":34,"centralContacts":39,"locations":48,"responsibleParty":85,"collaborators":89,"id":93,"slug":94,"hasResults":95,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":34,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":34,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":51,"whyStopped":34,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,15,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Subjects (Physical \u002F Virtual)","ACTIVE_COMPARATOR","Cross-over design for healthy subjects, physical optokinetic stimulation in advance to virtual optokinetic stimulation.",[13,14],"Diagnostic Test: Postural Response upon physical optokinetic stimulation","Diagnostic Test: Postural Response upon virtual optokinetic stimulation",{"label":16,"type":10,"description":17,"interventionNames":18},"Healthy Subjects (Virtual \u002F Physical)","Cross-over design for healthy subjects, virtual optokinetic stimulation in advance to physical optokinetic stimulation.",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Patients (Physical)","EXPERIMENTAL","These patients are only examined with the physical stimulation to avoid excessive symptom burden.",[13],{"label":25,"type":21,"description":26,"interventionNames":27},"Patients (Virtual)","These patients are only examined with the virtual stimulation to avoid excessive symptom burden.",[14],[29,35],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DIAGNOSTIC_TEST","Postural Response upon physical optokinetic stimulation","The physical optokinetic stimulation consists of rotating stimulation in either direction using a physical disc (de Vestel, et al., 2022; Guerraz et al., 2001; van Ombergen et al., 2016). The assessment is conducted in complete dark, unless the fluorescent dots (approx. 11% covered of the disc area.). The disc has a diameter of 1 m. Stimulation time per trial will be 30 s.",[9,16,20],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Postural Response upon virtual optokinetic stimulation","The virtual optokinetic stimulation is implemented in virtual reality goggles (Meta Quest 3, Meta Platforms, Menlo Park, CA, USA) applying oscillating and rotating stimulation in frontal and vertical axis with coherent or incoherent stimuli. The assessment in the virtual environment will be as similar as possible compared the physical stimulation. Hence, the virtual environment simulation complete dark, unless the fluorescent dots (approx. 15% covered of the disc area.). In addition to the rotating condition, the virtual dots are able to oscillate on the horizontal or vertical axis to create a more sensitive evaluation method than the physical one (Laurens et al., 2011). Stimulation time per trial will be 30 s.",[9,16,25],[40,45],{"name":41,"role":42,"phone":43,"phoneExt":34,"email":44},"Dominik Straumann, Prof. Dr. med.","CONTACT","+41 44 255 55 64","Dominik.Straumann@uzh.ch",{"name":46,"role":42,"phone":34,"phoneExt":34,"email":47},"Samuel Meyer, MSc","Samuel.Meyer3@uzh.ch",[49,72],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"BrainCare Medical Group","RECRUITING","Zurich","Canton of Zurich","8002","Switzerland","CH",{"type":58,"coordinates":59},"Point",[60,61],8.55,47.36667,{"lat":61,"lon":60},[64,68,70],{"name":65,"role":42,"phone":66,"phoneExt":34,"email":67},"Nina Feddermann, Dr. med.","+41 44 500 41 50","nina.feddermann@braincare.swiss",{"name":34,"role":42,"phone":66,"phoneExt":34,"email":69},"info@braincare.swiss",{"name":65,"role":71,"phone":34,"phoneExt":34,"email":34},"PRINCIPAL_INVESTIGATOR",{"facility":73,"status":51,"city":52,"state":53,"zip":74,"country":55,"countryCode":56,"cosmosGeoPoint":75,"geoPoint":77,"contacts":78},"University Hospital Zurich, Department of Neurology","8006",{"type":58,"coordinates":76},[60,61],{"lat":61,"lon":60},[79,81,84],{"name":41,"role":42,"phone":43,"phoneExt":34,"email":80},"Dominik.Straumann@usz.ch",{"name":46,"role":42,"phone":82,"phoneExt":34,"email":83},"+41 43 253 73 17","Samuel.Meyer@usz.ch",{"name":41,"role":71,"phone":34,"phoneExt":34,"email":34},{"type":86,"investigatorFullName":87,"investigatorTitle":88,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"SPONSOR_INVESTIGATOR","Dominik Straumann","Prof. Dr. med.",[90,92],{"name":91,"class":6},"University Hospital, Zürich",{"name":50,"class":6},"100584721","dizziness-due-to-visual-stimuli-in-patients-with-concussion-and-other-causes-of-dizziness-examination-of-balance-behaviour-100584721",false,"NCT06893029","Dizziness Due to Visual Stimuli in Patients With Concussion and Other Causes of Dizziness: Examination of Balance Behaviour","Visually Induced Dizziness in Concussed and Non-Concussed Dizzy Patients: Identifying the Pathophysiology of Postural Control Upon Optokinetic Stimuli","Inclusion Criteria:\n\n* Age between 18 and 60 years\n* Binocular vision\n* Recent concussion\u002FmTBI within 4 weeks to 18 months post-injury for concussed patients\n* Diagnosis related to dizziness or VID within 4 weeks to 18 months for non-concussed dizzy patients (including vestibular migraine)\n* Signed ICF for included participants or signed general consent for retrospectively included patients if an ICF cannot be obtained.\n\nExclusion Criteria:\n\n* BMI greater than 30\n* Acute vestibular syndrome lasting at least 24 hours\n* Severe non-correctable visual impairment\n* Balance issues not dizziness-related, including:\n\n  1. Neurological conditions (e.g., migraine)\n  2. Orthopaedic conditions (e.g., lower extremity injury)\n  3. Infectious diseases\n  4. Other medical contexts\n* Dizziness attributed to prescribed drugs, substance abuse, or mental disorders\n* Cognitive impairments compromising task comprehension\n* Preceding history of traumatic brain injury in the last 12 months\n* History of severe traumatic brain injury with persisting impairments\n* Other potentially confounding problems (e.g., psychiatric disease)\n* Frequent episodes of rotatory vertigo",true,"ALL","18 Years","60 Years",{"count":105,"type":106},240,"ESTIMATED","INTERVENTIONAL",[109],"NA","This research project aims to measure how balance is affected by special visual stimulation. Dizziness caused by complex moving visual patterns, known as optokinetic stimulation, is usually called visually induced dizziness (VID).\n\nThe study includes patients with persistent symptoms after a concussion and those with non-traumatic dizziness. Healthy participants serve as a control group for the comparison of balance and symptom responses.\n\nThe optokinetic stimulation is done using either a physical rotating disk or a virtual reality (VR) headset. The visual effects are created by bright moving dots. During the stimulation, these patterns move in a specific manner and directions while the subject's balance is recorded. Symptoms such as dizziness, headache, and nausea are also documented.\n\nThe goal of this project is to improve objective diagnosis of VID. By comparing patients and healthy subjects, the study aim to assess the severity of the disorder. It is also assumed that using different visual stimuli during the balance assessment will offer more sensitive and accurate results.\n\nIn the long term, this innovative assessment method shall support clinicians to establish the diagnosis of VID, and improve the treatment and management of patients with VID.",[112,113,114,115],"Dizziness","Concussion (Diagnosis)","Traumatic Brain Injury","Balance Assessment",[117],"Visually induced dizziness","2025-09-15",{"date":120,"type":121},"2025-09-19","ACTUAL",{"date":123,"type":121},"2025-05-14",{"date":125,"type":106},"2027-10-31",{"name":87,"class":6},2]