[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582118":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":30,"centralContacts":35,"locations":10,"responsibleParty":40,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":10,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":10,"studyType":57,"phases":10,"briefSummary":58,"conditions":59,"keywords":10,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":10},{"fullName":5,"class":6},"Zhujiang Hospital","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"control",null,"HPV16(-) HPV18(-) TCT(-)",[13],"Other: Reproductive tract microbiota",{"label":15,"type":10,"description":16,"interventionNames":17},"Case group 1","HPV16(+) \u002FHPV18(+) TCT(-) CIN\\\u003C2",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Case group 2","HPV16(+) \u002FHPV18(+) TCT(+) CIN\\\u003C2",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Case group 3","HPV16(+) \u002FHPV18(+) TCT(+) CIN≥2+",[13],[27],{"type":6,"name":28,"description":28,"armGroupLabels":29,"otherNames":10},"Reproductive tract microbiota",[15,19,23,9],[31],{"name":32,"affiliation":33,"role":34},"Muxuan Chen, Doctor","Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":10,"email":39},"CONTACT","+8613580561916","muxuanchen@126.com",{"type":34,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Muxuan Chen","Diagnostic Technician","100582118","dna-methylation-and-the-increased-risk-of-cervical-cancer-development-100582118",false,"NCT06859151","DNA Methylation and the Increased Risk of Cervical Cancer Development","The Role of the Genital Tract Microbiota in Cervical Epithelial Cell DNA Methylation and the Increased Risk of Cervical Cancer Development","Inclusion Criteria:\n\n1. Aged 18-50 years old, with a history of sexual activity\n2. HPV and TCT tests are performed concurrently in the gynecology clinic\n3. Those with abnormal HPV and TCT test results undergo tissue pathological testing\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding\n2. Patients with immunological disorders or severe autoimmune diseases, such as AIDS, SLE\n3. Those who have had organ transplants or are currently using immunosuppressive agents\n4. Use of vaginal douching within 48 hours before sample collection\n5. Use of vaginal probiotics within one month before sample collection\n6. Use of vaginal antibiotics or antifungal treatments within one month before sample collection\n7. History of surgery related to cervical intraepithelial neoplasia (CIN), including but not limited to conization of the cervix, LEEP procedures, etc.\n8. Blood samples (avoid sampling during menstruation), insufficient remaining sample volume to support subsequent analysis needs, and samples not stored as required.",true,"FEMALE","15 Years","50 Years",{"count":55,"type":56},2000,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the correlation between reproductive tract microbiota and DNA methylation in cervical epithelial cells, as well as its impact on the development of cervical cancer, through a paired case-control clinical study",[60,61],"Cervical Cancer","Papillomavirus Infections","NOT_YET_RECRUITING","2025-03-04",{"date":65,"type":66},"2025-03-05","ACTUAL",{"date":68,"type":56},"2025-03-20",{"date":70,"type":56},"2026-12-30",{"name":5,"class":6}]