[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100326237":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":33,"responsibleParty":51,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":18,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":35,"whyStopped":18,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"University of Illinois at Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercising","ACTIVE_COMPARATOR","12 weeks of aerobic exercise training",[13],"Other: Exercise training",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-exercising","NO_INTERVENTION","standard of care",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Exercise training","Twelve weeks of aerobic exercise training",[9],[25],{"name":26,"affiliation":5,"role":27},"Abeer Mohamed, MD, PhD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":18,"email":32},"CONTACT","3127539998","amahmo4@uic.edu",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Chicago","Illinois","60612","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-87.65005,41.85003,{"lat":45,"lon":44},[48],{"name":49,"role":30,"phone":50,"phoneExt":18,"email":32},"Abeer M Mohamed, MD, PhD","312-355-8099",{"type":27,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Abeer M. Mohamed","Postdoctoral Research Associate",[55],{"name":56,"class":57},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100326237","dna-methylation-and-vascular-function-100326237",false,"NCT03527420","DNA Methylation and Vascular Function","DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight Loss","Inclusion Criteria:\n\n* BMI ≥ 35 kg\u002Fm2\n* Between ages 18-50 years\n* Not pregnant\n* Approved for a bariatric surgery\n\nExclusion Criteria:\n\n* To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded\n* Pregnant women will be excluded, as they will not be eligible for bariatric surgery\n* Current smokers\n* Currently abusing alcohol or drugs",true,"ALL","18 Years","50 Years",{"count":70,"type":71},80,"ESTIMATED","INTERVENTIONAL",[74],"NA","The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive\u002Ftherapeutic interventions such as aerobic exercise.",[77,78],"Obesity","Vascular Dysfunction",[77,80,81,82,83,84,85,86,87,88,89,90],"DNA methylation","Exercise","Weight loss","Bariatric","Macrovascular","Microvascular","Epigenetics","Adipose tissue","Adipocytokines","Inflammation","Cardiovascular","2025-09-11",{"date":93,"type":94},"2025-09-15","ACTUAL",{"date":96,"type":94},"2019-10-11",{"date":98,"type":71},"2026-08-31",{"name":5,"class":6},1]