[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560887":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":51,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":10,"overallStatus":73,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of Campania Luigi Vanvitelli","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Young healthy subjects",null,"This cohort is characterized by 50 healthy subjects aged \\\u003C 40 years (blood donor volonteers)",[13],"Other: RRBS",{"label":15,"type":10,"description":16,"interventionNames":17},"Aged healthy subjects","This cohort is characterized by 50 healthy subjects aged \\> 60-65 years (blood donor volonteers) without signs and symptoms of heart failure",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Patients with heart failure","This cohort is characterized by 50 subjects aged \\> 60-65 years with signs and symptoms of heart failure with preserved ejection fraction",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"RRBS","Measure of genomic regions with differentially methylated profiles and differentially expressed protein",[15,19,9],[28],"O-Link Targeted Proteomics",[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Giuditta Benincasa, PhD","CONTACT","3245511161","giuditta.benincasa@unicampania.it",[36],{"facility":5,"status":10,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Naples","No States Available","80138","Italy","IT",{"type":43,"coordinates":44},"Point",[45,46],14.26811,40.85216,{"lat":46,"lon":45},[49,50],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":10},{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Giuditta Benincasa","Principal Investigator","100560887","dna-methylation-trajectories-in-aging-100560887",false,"NCT06582992","DNA Methylation Trajectories in Aging","EPIGENETIC-SENSITIVE BIOMARKERS OF INFLAMMAGING FROM HEALTHY TO HEART FAILURE DISEASE","EPI-GERAS","Inclusion Criteria:\n\n* Healthy subjects aged between 18 and 40 years\n* Aged subjects (≥65) without signs and symptoms of heart failure\n* Aged subjects (≥65) with diagnosis of heart failure with preserved ejection fraction (EF major than 50%)\n\nExclusion Criteria:\n\n* Heart failure with reduced ejection fraction (EF minor than 40%)\n* Heart failure with mildly reduced EF (HFmrEF) (EF 41-49%)\n* History or diagnosis of cancer and inflammatory diseases","ALL","18 Years",{"count":66,"type":67},150,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging.\n\nThe main question it aims to answer is:\n\n-Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging?\n\nOur goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).",[71,72],"Heart Failure","Aging","NOT_YET_RECRUITING","2024-08-31",{"date":76,"type":77},"2024-09-03","ACTUAL",{"date":79,"type":67},"2024-11",{"date":81,"type":67},"2025-11",{"name":5,"class":6},1]