[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605666":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":35,"locations":41,"responsibleParty":60,"collaborators":29,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":29,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":29,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":29,"overallStatus":43,"whyStopped":29,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group D20","EXPERIMENTAL","Patients will receive 0.5µg\u002Fkg dexmedetomidine (over 10 min) 20 min before induction of anesthesia then saline (over 10 min) 10 min before induction of anesthesia.",[13],"Drug: Dexmedetomidine",{"label":15,"type":10,"description":16,"interventionNames":17},"Group D10","Patients will receive saline (over 10 min) 20 min before induction of anesthesia then 0.5µg\u002Fkg dexmedetomidine (over 10 min) 10 min before induction of anesthesia.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Group C","PLACEBO_COMPARATOR","Patients will receive saline before induction of anesthesia as a control group.",[23],"Drug: Saline",[25,30,32],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"DRUG","Dexmedetomidine",[9],null,{"type":26,"name":27,"description":16,"armGroupLabels":31,"otherNames":29},[15],{"type":26,"name":33,"description":21,"armGroupLabels":34,"otherNames":29},"Saline",[19],[36],{"name":37,"role":38,"phone":39,"phoneExt":29,"email":40},"Mohammed S Elsharkawy, MD","CONTACT","00201148207870","mselsharkawy@med.tanta.edu.eg",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Tanta","El-Gharbia","31527","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.00192,30.78847,{"lat":53,"lon":52},[56,57],{"name":37,"role":38,"phone":39,"phoneExt":29,"email":40},{"name":58,"role":59,"phone":29,"phoneExt":29,"email":29},"Saad A Moharam, MD","PRINCIPAL_INVESTIGATOR",{"type":59,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Mohammed Said ElSharkawy","Lecturer of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.","100605666","do-increasing-preoperative-timing-of-single-dexmedetomidine-dose-have-an-effect-on-stress-response-of-laryngoscopy-and-intubation-100605666",false,"NCT07165483","Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?","Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation? A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n\nExclusion Criteria:\n\n* Severe cardiovascular problems.\n* Respiratory disorders.\n* Diabetes.\n* Hypertension.\n* Obesity.\n* Allergic reaction to study drugs.\n* Patients on antihypertensive medication (α-methyldopa, clonidine, or other α2-adrenergic agonists)\n* Medications that affect heart rate (HR) or blood pressure (BP).\n* Pregnant.\n* Currently breast-feeding women.\n* History of sleep apnea.\n* Those for emergency procedures.","ALL","18 Years","65 Years",{"count":74,"type":75},45,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.",[81,27,82,83,84],"Time","Stress Response","Laryngoscopy","Intubation","2025-09-11",{"date":87,"type":88},"2025-09-12","ACTUAL",{"date":85,"type":88},{"date":91,"type":75},"2026-03-01",{"name":5,"class":6},1]