[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626871":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":57,"collaborators":25,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":25,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":87,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Brigham and Women's Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Day Shift -> Night Shift","EXPERIMENTAL","Day Shift protocol first, then Night Shift protocol",[13,14],"Behavioral: Day shift","Behavioral: Night shift",{"label":16,"type":10,"description":17,"interventionNames":18},"Night shift -> Day shift","Night shift protocol first, then Day Shift protocol",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Day shift","Research participants will be assigned to day shift condition in which sleep-wake and meal schedules are aligned with the internal circadian system",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Night shift","Research participants will be assigned to simulated night shift condition in which sleep-wake and meal schedules are misaligned with the internal circadian system",[9,16],[31],{"name":32,"affiliation":5,"role":33},"Jingyi Qian, PhD","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","617-525-7423","jqian5@mgb.org",[40],{"facility":5,"status":25,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Boston","Massachusetts","02115","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-71.05977,42.35843,{"lat":50,"lon":49},[53],{"name":54,"role":36,"phone":55,"phoneExt":25,"email":56},"Vy Nguyen, B.S.","(617)-525-0662","vnguyen42@bwh.harvard.edu",{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Jingyi Qian","Assistant Professor","100626871","does-circadian-misalignment-have-sex-specific-effects-on-metabolism-100626871",false,"NCT07441265","Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?","Role of Biological Sex in Metabolic Responses to Night Work","Inclusion Criteria:\n\n* 18-40 years of age\n* Body Mass Index 18.5-24.9 kg\u002Fm2\n* Non-smokers, no current tobacco or e-cigarette use\n* Healthy with no acute or chronic medical and psychiatric disorders\n* Sex assigned at birth consistent with reproductive anatomy at enrollment (per protocol definition)\n\nExclusion Criteria:\n\n* History of drug or alcohol dependency\n* History of psychiatric illness or disorder\n* Pregnant\n* No prior gender-affirming hormone therapy and no gonadectomy",true,"ALL","18 Years","40 Years",{"count":72,"type":73},36,"ESTIMATED","INTERVENTIONAL",[76],"NA","This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger\u002Ffullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.",[79,80],"Circadian Misalignment","Sex Differences",[82,83,84,85,86],"circadian rhythm","sex differences","night work","glucose control","appetite regulation","NOT_YET_RECRUITING","2026-02-23",{"date":90,"type":91},"2026-02-27","ACTUAL",{"date":93,"type":73},"2026-10-01",{"date":95,"type":73},"2030-09-30",{"name":5,"class":6},1]