[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521360":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":33,"centralContacts":38,"locations":48,"responsibleParty":61,"collaborators":65,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":81,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":23,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":51,"whyStopped":23,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Amsterdam UMC, location VUmc","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Strengthening the brain","EXPERIMENTAL","Participants receive 30 minutes of 1-on-1 fitness training, dietary advice, and mental coaching, in addition to twice 20 minutes fitness at home, and 60 minutes of cognitive training each week for four months.",[13],"Behavioral: Strenghtening the brain",{"label":15,"type":10,"description":16,"interventionNames":17},"Strengthening the mind","Partiicpants receive biweekly 1-on-1 coaching by a trained work-coach who has MS to identify challenges at work and implement solutions. It is completed when satisfactory solutions have been implemented for all challenges or after four months.",[18],"Behavioral: Strengthening the mind",{"label":20,"type":21,"description":22,"interventionNames":23},"Enhanced usual care","NO_INTERVENTION","Participants receiving general information about cognitive impairment in MS and following care as usual for four months.",null,[25,30],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":23},"BEHAVIORAL","Strenghtening the brain","Lifestyle intervention containing physical exercise, lifestyle coaching, and cognitive training. The programme contains weekly 30 minutes 1-on-1 fitness and lifestyle coaching with two moments of exercise at home for 20 minutes. Online computerized cognitive training will be done for 60 minutes per week.",[9],{"type":26,"name":15,"description":31,"armGroupLabels":32,"otherNames":23},"Work-focused intervention combining the capability approach and the participatory approach. Together with a work-coach who has been diagnosed with MS themselves, participants will assess important work values, discover challenges participants are facing, think of solutions for these challenges, develop a plan of action and implement these solutions.",[15],[34],{"name":35,"affiliation":36,"role":37},"Hanneke E Hulst","Leiden University","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":23,"email":43},"Jip Aarts","CONTACT","+31 71 5275081","j.aarts@fsw.leidenuniv.nl",{"name":45,"role":41,"phone":46,"phoneExt":23,"email":47},"Shalina Saddal","+31 20 566 38 01","s.saddal@amsterdamumc.nl",[49],{"facility":50,"status":51,"city":52,"state":23,"zip":23,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":23},"Amsterdam University Medical Centers, location VUmc","RECRUITING","Amsterdam","Netherlands","NL",{"type":56,"coordinates":57},"Point",[58,59],4.88969,52.37403,{"lat":59,"lon":58},{"type":37,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":64,"oldNameTitle":23,"oldOrganization":23},"Hanneke Hulst","Professor","Universiteit Leiden",[66,67,70,72,75,77],{"name":64,"class":6},{"name":68,"class":69},"Personal Fitness Nederland","UNKNOWN",{"name":71,"class":69},"MS Vereniging Nederland",{"name":73,"class":74},"Merck B.V., Netherlands","INDUSTRY",{"name":76,"class":74},"Genzyme, a Sanofi Company",{"name":78,"class":69},"MS Sherpa","100521360","dont-be-late-postponing-cognitive-decline-and-preventing-early-unemployment-in-people-with-multiple-sclerosis-100521360",false,"NCT06068582","Don't be Late! Postponing Cognitive Decline and Preventing Early Unemployment in People With Multiple Sclerosis","DBL","Inclusion Criteria:\n\n* Confirmed MS diagnosis according to the McDonald 2017 criteria\n* Age between 18 and 67\n* No changes in disease modifying therapy prior to inclusion (i.e., no changes in last 3 months) - this criterion only applies at inclusion to ensure participants are in a stable situation at the start of the study and for follow-up measures, changes in treatment will be registered but will not result in exclusion from the study\n* no current relapse or steroid treatment in the six weeks prior to study visits\n* presence of mild cognitive deficits (at least one test with a Z-score of -1.0 to -1.99 below norm scores of healthy controls on the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery\n* being able to participate in an exercise intervention (i.e., EDSS \\\u003C 6.0)\n* fulfilling safety criteria for MRI (no metal inside body, not pregnant, no claustrophobia)\n\nExclusion Criteria:\n\n* presence of neurological (other than MS) and psychiatric disorders\n* a current or history of drug or alcohol abuse\n* being unable to speak or read Dutch\n* currently on sick leave for a period of 6 weeks or longer\n* currently pregnant","ALL","18 Years","67 Years",{"count":90,"type":91},270,"ESTIMATED","INTERVENTIONAL",[94],"NA","The goal of this randomized controlled trial is to compare the effectiveness of two innovative interventions aimed at preventing cognitive decline and work-related problems to enhanced usual care in improving quality of life in people with multiple sclerosis. Secondary objectives are:\n\n* to compare the effectiveness of the investigated interventions in improving cognitive, psychological, and work functioning, and in enhancing the brain's functional network\n* to examine which factors (i.e., baseline cognitive, psychological, work, and brain MRI-parameters) are predictive of the response to the investigated interventions\n* aim to qualitatively reflect on the process and outcome of the investigated interventions considering the perspectives of relevant stakeholders to allow for smooth and successful implementation in clinical practice\n\nParticipants will follow the intervention for four months, with follow-up measurements at six months after intervention and 12 months after intervention.",[97],"Multiple Sclerosis",[97,99,100,101,102,103],"Cognition","Exercise","Employment","Prevention","Health-related Quality of Life","2025-03-31",{"date":106,"type":107},"2025-04-03","ACTUAL",{"date":109,"type":107},"2023-04-16",{"date":111,"type":91},"2026-09",{"name":5,"class":6},1]