[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601380":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":53,"collaborators":26,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":26,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":26,"overallStatus":39,"whyStopped":26,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Minnesota","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"15 Breaths\u002F Day","ACTIVE_COMPARATOR","All sessions will be performed at 75% of each participant's PI max 7 days per week, for 6 weeks, using the POWERbreathe K5 device. Each session will take approximately 3-10 minutes depending on the assigned dose group.",[13],"Device: POWERbreathe K5",{"label":15,"type":10,"description":11,"interventionNames":16},"30 Breaths\u002F Day",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"45 Breaths\u002F Day",[13],[21],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","POWERbreathe K5","The POWERbreathe K5 is portable, battery-powered, and commercially available. No modifications to the FDA-approved design are being made. Its use in this study is consistent with prior published human research and does not constitute a significant deviation from labeled use in terms of safety or function.",[9,15,18],null,[28],{"name":29,"affiliation":5,"role":30},"Daniel Craighead, PhD","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Hannah Westerberg","CONTACT","612-624-1588","lewi1241@umn.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Minneapolis","Minnesota","55455","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-93.26384,44.97997,{"lat":49,"lon":48},[52],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":54,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100601380","dose-response-effects-of-inspiratory-muscle-strength-training-on-blood-pressure-and-vascular-function-100601380",false,"NCT07109739","Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function","Inclusion Criteria:\n\n* Age ≥18 years\n* Resting SBP ≥120 mmHg as measured during screening 1 \\& 2\n* Free from serious CV or metabolic diseases as identified by self-report and blood chemistry analysis.\n* No contraindications to IMST (recent abdominal surgery, ruptured eardrum, asthma with very low symptom perception, fractured ribs, or pneumothorax)\n* Language: English-speaking, with ability to comprehend study materials and instructions.\n* Pre-visit Compliance: Willing to comply with pre-visit instructions (avoiding food and caffeine ≥ 3 hours, vigorous exercise, alcohol, and non-prescribed medications ≥ 24 hours) prior to each measurement visit.\n* Lifestyle: Non-smokers (defined as self-report of not smoking cigarettes or vaping over the past year).\n\nExclusion Criteria:\n\n* Self-report of history of cardiovascular disease, or conditions affecting the ear (e.g., ruptured eardrum).\n* Recent abdominal surgery or presence of an abdominal hernia.\n* Asthma with very low symptom perception, frequent severe exacerbations, or abnormally low perception of dyspnea.\n* Ruptured eardrum or any other condition of the ear.\n* Markedly elevated left ventricular end-diastolic volume and pressure.\n* Current respiratory conditions such as a cold, sinusitis, or respiratory tract infection (participants may be included once they recover from the respiratory condition).\n* Female-Specific: Pregnant or planning to become pregnant during the study period.\n* Compliance: Unable or unwilling to comply with pre-visit restrictions (e.g., avoiding caffeine, alcohol, and exercise within specified hours before visits).","ALL","18 Years",{"count":64,"type":65},144,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.",[71,72],"Systolic Hypertension","Brachial Artery Flow-mediated Dilation","2025-11-24",{"date":75,"type":76},"2025-11-25","ACTUAL",{"date":78,"type":76},"2025-10-24",{"date":80,"type":65},"2027-03-31",{"name":5,"class":6},1]