[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545173":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":34,"centralContacts":38,"locations":47,"responsibleParty":65,"collaborators":33,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":33,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":33,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":33,"overallStatus":50,"whyStopped":33,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Melbourne","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"10-minute dose","EXPERIMENTAL","Daily guided mindfulness meditation practices of 10-minute duration.",[13],"Behavioral: Mindfulness meditation guided practice",{"label":15,"type":10,"description":16,"interventionNames":17},"20-minute dose","Daily guided mindfulness meditation practices of 20-minute duration.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"30-minute dose","Daily guided mindfulness meditation practices of 30-minute duration.",[13],{"label":23,"type":24,"description":25,"interventionNames":26},"3-4 minute minimal dose","ACTIVE_COMPARATOR","Short daily meditation approximating 3-4 minute duration (akin to the breathing space practice in Mindfulness-based Cognitive Therapy or short practices in popular meditation apps).",[13],[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"BEHAVIORAL","Mindfulness meditation guided practice","Participants will listen to recordings of mindfulness meditation practices from a newly developed 28-day program.",[9,15,23,19],null,[35],{"name":36,"affiliation":5,"role":37},"Nicholas T Van Dam","PRINCIPAL_INVESTIGATOR",[39,44],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},"Nicholas T Van Dam, PhD","CONTACT","+61 3 8344 3644","nicholas.vandam@unimelb.edu.au",{"name":45,"role":41,"phone":42,"phoneExt":33,"email":46},"Nicholas I Bowles","nbowles@student.unimelb.edu.au",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":33,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Contemplative Studies Centre, The University of Melbourne","RECRUITING","Carlton","Victoria","Australia","AU",{"type":56,"coordinates":57},"Point",[58,59],144.96667,-37.8,{"lat":59,"lon":58},[62],{"name":63,"role":41,"phone":64,"phoneExt":33,"email":43},"Nicholas Van Dam, PhD","+61 3 9035 5511",{"type":37,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Nicholas Van Dam","Associate Professor","100545173","dose-response-effects-of-mindfulness-meditation-100545173",false,"NCT06378450","Dose-Response Effects of Mindfulness Meditation","Examining Dose-Response Effects of Mindfulness Meditation Interventions on Wellbeing: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Reside in Australia, with no plans to relocate or travel overseas during the intervention period;\n* Sufficient comprehension of the English language to complete measures;\n* Register for an account and agree to the Terms and Conditions of Unforgettable.Me;\n* If suffering anxious or depressive symptoms of moderate severity (defined by \\> 19 on the Patient-Reported Outcomes Measurement Information System \\[PROMIS\\] Level 2 Anxiety or \\> 22 on the PROMIS Level 2 Depression), must agree to continue recommended routine medical treatment for eligible underlying mental and\u002For physical health conditions or the duration of the study and to seek additional treatment if indicated by deterioration of symptoms;\n* No or minimal experience with meditation, defined as less than 25 hours over the past 6 months; never attended a multi-day mindfulness course (e.g., Mindfulness-Based Stress Reduction, Vipassana). If 50% of our target sample size has not bee recruited within the first three months of active recruitment, the inclusion criteria will be broadened to include participants with up to 100 hours in the past 6 months.\n\nExclusion Criteria:\n\n* Self-reported current or lifetime serious mental illness (e.g., neurodevelopmental, schizophrenia spectrum, bipolar, obsessive-compulsive, trauma-related, dissociative or personality disorder);\n* Anxious and depressive symptoms in the severe range (defined by \\>27 on the PROMIS Level 2 Anxiety or \\> 32 on the PROMIS Level 2 Depression);\n* Psychological distress symptoms in the severe range (Kessler Psychological Distress Scale \\[K10\\] \\>= 30);\n* Threshold scores on pre-screening and follow-up measures exceeded for Mania, Suicidal Ideation, Psychosis, Repetitive Thoughts \\& Behaviors, Dissociation\n* Moderate alcohol, tobacco, or drug use;\n* Self-reported diagnosis of neurological condition (e.g., traumatic brain injury, amnesia, epilepsy, stroke, etc.);\n* Self-reported presence of any serious medical condition (e.g., cancer, thyroid disorder, multiple sclerosis, etc.);\n* Recent bereavement or major loss;\n* History of unexplored, untreated traumatic experiences or adverse childhood events.",true,"ALL","18 Years","65 Years",{"count":80,"type":81},860,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this randomized controlled trial is to test for evidence of dose-response effects in a sample of healthy adults with little to no prior experience with meditation.\n\nThe main question it aims to answer is whether larger doses of mindfulness meditation yield greater positive changes in wellbeing than smaller doses.\n\nOur hypotheses are that (1) larger doses of mindfulness training will yield significantly larger effects, and (2) different doses will be significantly associated with variation in participant engagement, with lower engagement associated with higher doses.\n\nResearchers will compare each of three dose conditions, 10-min, 20-min, 30-min, against a minimal dose condition of 3-4 min.\n\nParticipants will take a 28-day mindfulness meditation course, with guided audio instructions provided daily throughout the intervention period (excluding one rest day per week). They will also be asked to respond to surveys before, during, and after the intervention.",[87,88],"Well-Being, Psychological","Depression","2025-03-25",{"date":91,"type":92},"2025-03-30","ACTUAL",{"date":94,"type":92},"2024-05-01",{"date":96,"type":81},"2025-06-30",{"name":5,"class":6},1]