[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100563690":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":51,"centralContacts":55,"locations":61,"responsibleParty":78,"collaborators":81,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":93,"sex":98,"minAge":99,"maxAge":59,"enrollmentInfo":100,"targetDuration":59,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":64,"whyStopped":59,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Aerobic Exercise (AE) only","EXPERIMENTAL","Aerobic exercise (AE) training will consist of 60 min of treadmill, elliptical, or bike exercise at a moderate to vigorous (50-80% of heart rate reserve). Intensity of the exercise sessions will be built of gradually. Sessions will occur 2 times per week for the duration of the year.",[13],"Behavioral: Aerobic exercise only",{"label":15,"type":10,"description":16,"interventionNames":17},"30 min of resistance exercise (RE)","30 min of resistance exercise (RE) will consist of 30 total minutes of resistance exercise each week (15 min each session) in addition to 60 min of aerobic exercise (AE) each week (30 min each session). Each 15 min session of RE will consist of 2 sets of 8-15 repetitions at 50-80% of 1-rep max of 4 exercises. AE will consist of treadmill, elliptical, or bike exercise at moderate to vigorous intensity (50-80% of heart rate reserve). Intensity of the exercise sessions will be increased gradually. With 1 min rest between sets, this plan is estimated to take approximately 45 min per session. Sessions will occur 2 times per week for the duration of 1 year.",[18],"Behavioral: 30 min of resistance exercise",{"label":20,"type":10,"description":21,"interventionNames":22},"60 min of resistance exercise (RE)","60 min of resistance exercise (RE) will consist of 60 total minutes of resistance exercise each week (30 min each session) in addition to 60 min of aerobic exercise each week (30 min each session). Each 30 min session of resistance exercise will consist of 2 sets of 8-15 repetitions at 50-80% of 1-rep max of 8 exercises. Aerobic exercise will consist of treadmill, elliptical, or bike exercise at moderate to vigorous intensity (50-80% of heart rate reserve). Intensity of the exercise sessions will be increased gradually. With 1 min rest between sets, this plan is estimated to take approximately 60 min per session. Sessions will occur 2 times per week for the duration of 1 year.",[23],"Behavioral: 60 min of resistance exercise",{"label":25,"type":10,"description":26,"interventionNames":27},"120 min of resistance exercise (RE)","120 min of resistance exercise (RE) will consist of 120 total minutes of resistance exercise each week (60 min each session) in addition to 60 min of aerobic exercise each week (30 min each session). Each 60 min session of resistance exercise will consist of 3 sets of 8-15 repetitions at 50-80% of 1-rep max of 10 exercises. Aerobic exercise will consist of treadmill, elliptical, or bike exercise at moderate to vigorous intensity (50-80% of heart rate reserve). Intensity of the exercise sessions will be increased gradually. With 1 min rest between sets, this plan is estimated to take approximately 90 min per session. Sessions will occur 2 times per week for the duration of 1 year.",[28],"Behavioral: 120 min of resistance exercise",[30,37,43,47],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","Aerobic exercise only","Aerobic exercise training will consist of 60 min of treadmill, elliptical, or bike exercise at a moderate to vigorous (50-80% of heart rate reserve). Intensity of the exercise sessions will be built of gradually. Sessions will occur 2 times per week for the duration of the year trial",[9],[36],"Aerobic Exercise",{"type":31,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"30 min of resistance exercise","30 min of resistance exercise (RE) will consist of 30 total minutes of resistance exercise each week (15 min each session) in addition to 60 min of aerobic exercise each week (30 min each session). Each 15 min session of resistance exercise will consist of 2 sets of 8-15 repetitions at 50-80% of 1-rep max of 4 exercises. Aerobic exercise will consist of treadmill, elliptical, or bike exercise at moderate to vigorous intensity (50-80% of heart rate reserve). Intensity of the exercise sessions will be increased gradually. With 1 min rest between sets, this plan is estimated to take approximately 45 min per session. Sessions will occur 2 times per week for the duration of 1 year.",[15],[42],"resistance training",{"type":31,"name":44,"description":21,"armGroupLabels":45,"otherNames":46},"60 min of resistance exercise",[20],[42],{"type":31,"name":48,"description":26,"armGroupLabels":49,"otherNames":50},"120 min of resistance exercise",[25],[42],[52],{"name":53,"affiliation":5,"role":54},"Duck-chul Lee, PhD","PRINCIPAL_INVESTIGATOR",[56],{"name":53,"role":57,"phone":58,"phoneExt":59,"email":60},"CONTACT","412-383-4004",null,"dclee@pitt.edu",[62],{"facility":63,"status":64,"city":65,"state":66,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"Physical Activity Research Center (PARC)","RECRUITING","Pittsburgh","Pennsylvania","15219","United States","US",{"type":71,"coordinates":72},"Point",[73,74],-79.99589,40.44062,{"lat":74,"lon":73},[77],{"name":53,"role":57,"phone":58,"phoneExt":59,"email":60},{"type":54,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":59,"oldOrganization":59},"Duck-chul Lee","Director of Physical Activity Research Center",[82,84,86,88],{"name":83,"class":6},"University of California, Riverside",{"name":85,"class":6},"Iowa State University",{"name":87,"class":6},"Harvard School of Public Health (HSPH)",{"name":89,"class":90},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100563690","dose-response-to-resistance-exercise-on-cardiovascular-health-100563690",false,"NCT06619444","Dose-Response to Resistance Exercise on Cardiovascular Health","DoReps","Inclusion Criteria:\n\n* Non-Smoker\n* Overweight or Obese: Body Mass Index 25-43 kg\u002Fm2\n* Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months\n* Walking \\\u003C7,000 steps\u002Fday at baseline\n* Capable of performing the required exercise training\n\nExclusion Criteria:\n\nAbsolute\n\n* Unstable coronary heart disease or heart failure\n* Uncontrolled arrhythmias or severe aortic stenosis\n* Acute myocarditis, endocarditis, or pericarditis\n* Cancer, requiring treatment in the past 5 years\n* Autoimmune diseases, affecting immune system\n* Plans to be away ≥4 weeks in the next 1 year\n* Pregnancy\u002Fanticipated pregnancy during the study\n* Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training\n* Uncontrolled Diabetes (HbA1c ≥8.0),\n* Hypertensive Blood Pressure ≥160 mm Hg Systolic and\u002For 100 mm Hg Diastolic,\n\nRelative (should consult a physician)\n\n* Major risk factors for coronary heart disease\n* Uncontrolled diabetes or musculoskeletal limitations","ALL","40 Years",{"count":101,"type":102},240,"ESTIMATED","INTERVENTIONAL",[105],"NA","A large body of evidence indicates numerous health benefits of physical activity, including prevention of cardiovascular disease (CVD), the leading cause of death in the US. This evidence has led to US Physical Activity Guidelines that recommend ≥150 min\u002Fweek of moderate or ≥75 min\u002Fweek of vigorous aerobic exercise (AE), plus resistance exercise (RE; such as weight lifting) on ≥2 days\u002Fweek. To date, current research has mostly focused on AE, and we know a great deal about the dose-response relation between AE and health, resulting in clear and practical guidance to the public on the recommended \"dose\" in min\u002Fweek. However, currently far less is known about the dose-response for RE: ≥2 days\u002Fweek are recommended, but with no duration specified. Thus, this project aims to provide clarity on the dose relationship between RE and health. This project will significantly contribute to developing more effective CVD prevention approaches, advancing prescriptive intervention guidelines, by helping to fill the important gaps in knowledge on effective minimum dose, beneficial optimal dose, and safe maximum dose of RE for CVD prevention. Thus, advancing prescriptive intervention guidelines, and provide important insights for future science of physical activity and health.",[108],"Cardiovascular Risk",[110],"Exercise","2025-08-07",{"date":113,"type":114},"2025-08-12","ACTUAL",{"date":116,"type":114},"2024-12-03",{"date":118,"type":102},"2027-12",{"name":5,"class":6},1]