[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571825":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":27,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":10},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"low dose isotretinoin",null,"Acne patients taking 20 mg daily isotretinoin",[13],"Diagnostic Test: Ocular Surface Disease Index (OSDI) questionnaire",{"label":15,"type":10,"description":16,"interventionNames":17},"high dose isotretinoin","Acne patients taking 0.5 mg\u002Fkg daily dose of isotretinoin",[13],{"label":19,"type":10,"description":10,"interventionNames":20},"Normal control",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Ocular Surface Disease Index (OSDI) questionnaire","The OSDI is a validated, self-administered questionnaire for assessing the presence and severity of ocular surface disease symptoms. The OSDI questionnaire includes 12 questions about the respondent's past week experience with the ocular symptoms, vision-related function, and environmental triggers",[19,15,9],{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Hagar El Sayed","University doctor","100571825","dry-eye-disease-with-isotretinoin-isotretinoin-100571825",false,"NCT06725290","Dry Eye Disease With Isotretinoin ISOTRETINOIN","Digital Assessment of Dry Eye Diseases in Acne Vulgaris Patients Receiving Isotretinoin Therapy","Inclusion Criteria:\n\n* Moderate to severe acne on isotretinoin\n\nExclusion Criteria:\n\n* Occular diseases causing dry eye\n* Pregnant females",true,"ALL","18 Years","40 Years",{"count":43,"type":44},60,"ESTIMATED","OBSERVATIONAL","The study aims to explore the effects of isotretinoin therapy on the dry eye parameters in acne vulgaris patients \\& determine if it is dose-dependent or not.",[48],"Acne Vulgaris","NOT_YET_RECRUITING","2025-05-10",{"date":52,"type":53},"2025-05-14","ACTUAL",{"date":55,"type":44},"2025-06-01",{"date":57,"type":44},"2025-09-30",{"name":5,"class":6}]