[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100357757":3},{"organization":4,"armGroups":7,"interventions":37,"overallOfficials":87,"centralContacts":91,"locations":97,"responsibleParty":118,"collaborators":10,"id":120,"slug":121,"hasResults":122,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":10,"eligibilityCriteria":126,"healthyVolunteers":127,"sex":128,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":10,"studyType":134,"phases":10,"briefSummary":135,"conditions":136,"keywords":141,"overallStatus":145,"whyStopped":10,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":155},{"fullName":5,"class":6},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",[8,25,29,33],{"label":9,"type":10,"description":11,"interventionNames":12},"Dry eye syndrome",null,"Dry eye syndrome patients were extracted from Taiwan Biobank.",[13,14,15,16,17,18,19,20,21,22,23,24],"Diagnostic Test: Whole-genome genotyping","Diagnostic Test: Whole-genome sequencing","Diagnostic Test: TCM pattern","Diagnostic Test: DNA Exome sequencing","Diagnostic Test: Physical examination indicators, blood, urine and biochemical function test","Diagnostic Test: Demographics, personal health behavior, living environment, dietary status, family history","Diagnostic Test: HLA typing","Diagnostic Test: Full-length 16S Amplicon Sequencing","Diagnostic Test: Epigenomic","Diagnostic Test: Metabolomics","Diagnostic Test: Environmental Toxic","Diagnostic Test: Medical Image",{"label":26,"type":10,"description":27,"interventionNames":28},"Health subjects","Health subjects were extracted from Taiwan Biobank.",[13,14,15,16,17,18,19,20,21,22,23,24],{"label":30,"type":10,"description":31,"interventionNames":32},"Sjögren's syndrome","Sjogren's syndrome patients were screened in the rheumatology outpatient departments and Center for Traditional Medicine at Taipei Veterans General Hospital, and were enrolled with the inclusion criteria: (1) aged between 20 and 75 years; (2) fulfilled the 2002 American-European Consensus Criteria for SS (AECG)",[13,14,15,16,17,18,19,20,21,22,23,24],{"label":34,"type":10,"description":35,"interventionNames":36},"other inflammation disease","Other inflammation disease were extracted from Taiwan Biobank.",[13,14,15,16,17,18,19,20,21,22,23,24],[38,43,47,51,55,59,63,67,71,75,79,83],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":10},"DIAGNOSTIC_TEST","Whole-genome genotyping","Using Whole-genome genotyping from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.",[9,26,30,34],{"type":39,"name":44,"description":45,"armGroupLabels":46,"otherNames":10},"Whole-genome sequencing","Using whole-genome sequencing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":48,"description":49,"armGroupLabels":50,"otherNames":10},"TCM pattern","We want to use TCM pattern to investigate the difference among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.",[9,26,30,34],{"type":39,"name":52,"description":53,"armGroupLabels":54,"otherNames":10},"DNA Exome sequencing","The DNA of dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease will take to do the DNA Exome sequencing.",[9,26,30,34],{"type":39,"name":56,"description":57,"armGroupLabels":58,"otherNames":10},"Physical examination indicators, blood, urine and biochemical function test","To investigate the difference of Physical examination indicators, blood, urine and biochemical function test among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.",[9,26,30,34],{"type":39,"name":60,"description":61,"armGroupLabels":62,"otherNames":10},"Demographics, personal health behavior, living environment, dietary status, family history","To investigate the difference among the demographics, personal health behavior, living environment, dietary status, family history of among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease.",[9,26,30,34],{"type":39,"name":64,"description":65,"armGroupLabels":66,"otherNames":10},"HLA typing","Using HLA typing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":68,"description":69,"armGroupLabels":70,"otherNames":10},"Full-length 16S Amplicon Sequencing","Using Full-length 16S Amplicon Sequencing from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":72,"description":73,"armGroupLabels":74,"otherNames":10},"Epigenomic","Using Epigenomic from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":76,"description":77,"armGroupLabels":78,"otherNames":10},"Metabolomics","Using Metabolomics from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":80,"description":81,"armGroupLabels":82,"otherNames":10},"Environmental Toxic","Using Environmental Toxic from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],{"type":39,"name":84,"description":85,"armGroupLabels":86,"otherNames":10},"Medical Image","Using Medical Image from Taiwan Biobank among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease to investigate the difference among the genetic variant, gene copy number, single nucleotide variation, chromosomal recombination, and very low-level gene expression differences.",[9,26,30,34],[88],{"name":89,"affiliation":5,"role":90},"Ching-Mao Chang, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[92],{"name":89,"role":93,"phone":94,"phoneExt":95,"email":96},"CONTACT","88628757453","333","magicbjp@gmail.com",[98],{"facility":99,"status":10,"city":100,"state":101,"zip":102,"country":103,"countryCode":104,"cosmosGeoPoint":105,"geoPoint":110,"contacts":111},"Ching-Mao Chang","Taipei","Taiwan (r.o.c.)","112","Taiwan","TW",{"type":106,"coordinates":107},"Point",[108,109],121.52639,25.05306,{"lat":109,"lon":108},[112,113,116],{"name":89,"role":93,"phone":10,"phoneExt":10,"email":10},{"name":114,"role":115,"phone":10,"phoneExt":10,"email":10},"Yen-Wenn Liu, Ph.D.","SUB_INVESTIGATOR",{"name":117,"role":115,"phone":10,"phoneExt":10,"email":10},"Hsueh-Ting Chu, Ph.D.",{"type":119,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100357757","dry-eye-syndrome-healthy-control-sjgrens-syndrome-and-other-inflammation-disease-in-taiwan-biobank-100357757",false,"NCT03938207","Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank","The Comprehensive Analysis of Health Records, TCM Constitution, Biomarker, and Whole-genome Sequencing Among Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan","Sjögren's syndrome\n\nInclusion Criteria:\n\n1. aged between 20 and 75 years\n2. fulfilled the 2002 American-European Consensus Criteria for SS (AECG) Exclusion Criteria: NA\n\nDry eye syndrome\n\nInclusion Criteria:\n\n1. aged between 20 and 75 years\n2. Schirmer's test less than 10 mm\u002F5 min Exclusion Criteria: NA\n\nInflammation disease\n\nInclusion Criteria:\n\n1. aged between 20 and 75 years\n2. Disease diagnosed with Inflammation Exclusion Criteria: NA",true,"ALL","20 Years","75 Years",{"count":132,"type":133},100000,"ESTIMATED","OBSERVATIONAL","The comprehensive analysis of health records, TCM constitution, biomarker, and whole-genome sequencing among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease in Taiwan: an integrated analysis between Taiwan Biobank and Sjögren's syndrome Database",[137,138,139,140],"Dry Eye Syndrome","Sjogren's Syndrome","Healthy Control","Inflammation",[9,30,142,143,48,140,144],"Gene modulation","Xerophthalmia","Healthy control","NOT_YET_RECRUITING","2022-08-09",{"date":148,"type":149},"2022-08-11","ACTUAL",{"date":151,"type":133},"2022-10-01",{"date":153,"type":133},"2027-12-31",{"name":5,"class":6},1]