[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502963":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":42,"responsibleParty":85,"collaborators":88,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":26,"eligibilityCriteria":96,"healthyVolunteers":92,"sex":97,"minAge":98,"maxAge":26,"enrollmentInfo":99,"targetDuration":26,"studyType":102,"phases":103,"briefSummary":105,"conditions":106,"keywords":26,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"Larissa University Hospital","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypercapnic COPD patient - Asymmetric or conventional nasal high flow cannula","EXPERIMENTAL","Patients with acute exacerbation of COPD and mild to moderate hypercapnic respiratory failure will be randomized to NHF oxygen therapy with asymmetric cannula OR conventional cannula",[13,14],"Device: Asymmetric nasal cannula - DUET","Device: Conventional nasal high flow cannula",{"label":16,"type":17,"description":18,"interventionNames":19},"Hypercapnic COPD patient - Conventional or asymmetric nasal high flow cannula","ACTIVE_COMPARATOR","Patients with acute exacerbation of COPD and mild to moderate hypercapnic respiratory failure will be randomized to NHF oxygen therapy with conventional cannula or Asymmetric cannula",[13,14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Asymmetric nasal cannula - DUET","DUET asymmetric nasal high flow interface that fits best to the patients' nostrils (size: one nostril of the patient should be fully occluded)\n\nPatients will be crossed-over between the 2 interventions",[9,16],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional nasal high flow cannula","Well-established conventional nasal high flow cannula (size: medium)\n\nPatients will be crossed-over between the 2 interventions",[9,16],[32],{"name":33,"affiliation":5,"role":34},"Konstantinos Gourgoulianis, Ph.D.","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Ioannis Pantazopoulos, Ph.D.","CONTACT","6945661525","0030","pantazopoulosioannis@yahoo.com",[43,63],{"facility":44,"status":45,"city":46,"state":26,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Sotiria General Hospital","RECRUITING","Athens","11527","Greece","GR",{"type":51,"coordinates":52},"Point",[53,54],23.72784,37.98376,{"lat":54,"lon":53},[57,61],{"name":58,"role":38,"phone":59,"phoneExt":40,"email":60},"Petros Bakakos, Ph.D.","6974748113","petros44@hotmail.com",{"name":58,"role":62,"phone":26,"phoneExt":26,"email":26},"PRINCIPAL_INVESTIGATOR",{"facility":64,"status":45,"city":65,"state":26,"zip":66,"country":48,"countryCode":49,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"University Hospital of Larissa","Larissa","41110",{"type":51,"coordinates":68},[69,70],22.42112,39.62847,{"lat":70,"lon":69},[73,74,78,79,82,83],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},{"name":75,"role":38,"phone":76,"phoneExt":40,"email":77},"Georgios Mavrovounis, MD","6993484469","gmavrovounis@gmail.com",{"name":37,"role":62,"phone":26,"phoneExt":26,"email":26},{"name":80,"role":81,"phone":26,"phoneExt":26,"email":26},"Konstantinos Tourlakopoulos, MD","SUB_INVESTIGATOR",{"name":75,"role":81,"phone":26,"phoneExt":26,"email":26},{"name":84,"role":81,"phone":26,"phoneExt":26,"email":26},"Athanasios Pagonis, MD",{"type":62,"investigatorFullName":86,"investigatorTitle":87,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ioannis Pantazopoulos","Assistant Professor of Emergency Medicine",[89],{"name":44,"class":6},"100502963","duet-versus-standard-interface-for-hypercapnic-copd-patients-100502963",false,"NCT05829083","DUET Versus Standard Interface for Hypercapnic COPD Patients","Asymmetric (DUET) Versus Conventional Nasal High Flow Interface for Management of Hypercapnic Patients With Mild to Moderate Acute Exacerbation of COPD: A Randomized, Crossover Clinical Trial","Inclusion Criteria:\n\n* acute exacerbation of COPD (defined as any worsening of the patient's respiratory symptoms that is beyond normal day-to-day variations and leads to change in medication)\n* mild-to-moderate acute hypercapnic respiratory failure (defined as 7.35\\>pH\\>7.25 and arterial CO2 tension (PaCO2) \\>45 mmHg)\n\nExclusion Criteria:\n\n* acute on chronic hypercapnic respiratory failure\n* severe facial deformity, facial burns, fixed upper airway obstruction\n* indication for imminent intubation and invasive mechanical ventilation (i.e. respiratory or cardiac arrest, diminished consciousness (Glasgow coma score \\\u003C8)\n* psychomotor agitation inadequately controlled by sedation\n* massive aspiration\n* persistent inability to remove respiratory secretions\n* severe haemodynamic instability unresponsive to fluids and vasoactive drugs\n* severe ventricular or supraventricular arrhythmias\n* life threatening hypoxaemia","ALL","18 Years",{"count":100,"type":101},50,"ESTIMATED","INTERVENTIONAL",[104],"NA","The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation.\n\nThe main questions the study aims to answer are:\n\n• Does the use of the asymmetric interface lead to:\n\n1. A greater decrease in the patients' carbon dioxide\n2. A greater decrease in respiratory rate and less dyspnea\n3. Less need for advanced oxygen therapy measures\n4. Same tolerance and comfort\n5. Lower heart rate and blood pressure\n\nParticipants will be asked to:\n\nWear the asymmetric and conventional cannulas for 3 hours each with a 30 minute gap in-between. Arterial blood samples and various clinical parameters will be collected throughout the study period.\n\nResearchers will compare the effect of asymmetric versus conventional cannulas to answer the aforementioned questions.",[107,108,109],"COPD Exacerbation","Hypercapnia","COPD","2025-09-03",{"date":112,"type":113},"2025-09-10","ACTUAL",{"date":115,"type":113},"2023-07-18",{"date":117,"type":101},"2025-12-01",{"name":5,"class":6},2]