[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545703":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":24,"locations":30,"responsibleParty":367,"collaborators":369,"id":375,"slug":376,"hasResults":377,"nctId":378,"briefTitle":379,"officialTitle":380,"acronym":381,"eligibilityCriteria":382,"healthyVolunteers":377,"sex":383,"minAge":384,"maxAge":11,"enrollmentInfo":385,"targetDuration":11,"studyType":388,"phases":389,"briefSummary":391,"conditions":392,"keywords":394,"overallStatus":33,"whyStopped":11,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":409},{"fullName":5,"class":6},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Association between thrombosis burden and occurrence of PTS","EXPERIMENTAL",null,[13],"Other: Quantification of deep vein thrombosis burden and assessment of post-thrombotic syndrome",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":11},"Quantification of deep vein thrombosis burden and assessment of post-thrombotic syndrome","Post-thrombotic syndrome will be assessed by the Villalta score until 6 months of follow-up.\n\nData collected from colour doppler ultrasound will be used to calculate the Venous Volumetric Index to quantify deep vein thrombosis burden until 6 months of follow-up.",[9],[20],{"name":21,"affiliation":22,"role":23},"Antoine ELIAS","Centre Hospitalier Intercommunal Toulon La Seyne-sur-Mer","STUDY_DIRECTOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":11,"email":29},"Magali CESANA","CONTACT","0483772060","magali.cesana@ch-toulon.fr",[31,49,63,78,91,101,111,124,132,146,162,176,190,201,211,221,235,249,259,272,282,294,306,317,331,345,357],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"CH de Vichy","RECRUITING","Vichy","Allier","03200","France","FR",{"type":40,"coordinates":41},"Point",[42,43],3.42577,46.12709,{"lat":43,"lon":42},[46],{"name":47,"role":27,"phone":11,"phoneExt":11,"email":48},"Fabrice ABBADIE, MD","fabrice.abbadie@ch-vichy.fr",{"facility":50,"status":33,"city":51,"state":52,"zip":53,"country":37,"countryCode":38,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Centre Hospitalier de Carcassonne","Carcassonne","Aude","11010",{"type":40,"coordinates":55},[56,57],2.34863,43.21649,{"lat":57,"lon":56},[60],{"name":61,"role":27,"phone":11,"phoneExt":11,"email":62},"Géraldine PAOLI-CAZANAVE","geraldine.paoli-cazanave@ch-carcassonne.fr",{"facility":64,"status":65,"city":66,"state":67,"zip":68,"country":37,"countryCode":38,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Hôpital d'Aubagne","NOT_YET_RECRUITING","Aubagne","Bouches-du-Rhône","13400",{"type":40,"coordinates":70},[71,72],5.57067,43.29276,{"lat":72,"lon":71},[75],{"name":76,"role":27,"phone":11,"phoneExt":11,"email":77},"Walfroy Radix, MD","walfroy.radix@ch-aubagne.fr",{"facility":79,"status":33,"city":80,"state":67,"zip":81,"country":37,"countryCode":38,"cosmosGeoPoint":82,"geoPoint":86,"contacts":87},"Hôpital Saint Joseph","Marseille","13008",{"type":40,"coordinates":83},[84,85],5.38107,43.29695,{"lat":85,"lon":84},[88],{"name":89,"role":27,"phone":11,"phoneExt":11,"email":90},"Benjamin Ally, MD","allybsa@gmail.com",{"facility":92,"status":33,"city":80,"state":67,"zip":93,"country":37,"countryCode":38,"cosmosGeoPoint":94,"geoPoint":96,"contacts":97},"Hôpital La Timone, 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SECONDI","dr.jf.secondi@gmail.com",{"facility":102,"status":33,"city":112,"state":113,"zip":114,"country":37,"countryCode":38,"cosmosGeoPoint":125,"geoPoint":127,"contacts":128},{"type":40,"coordinates":126},[117,118],{"lat":118,"lon":117},[129],{"name":130,"role":27,"phone":11,"phoneExt":11,"email":131},"Céline DE MARI","dr.celine.demari@gmail.com",{"facility":133,"status":33,"city":134,"state":135,"zip":136,"country":37,"countryCode":38,"cosmosGeoPoint":137,"geoPoint":141,"contacts":142},"CHU de Dijon","Dijon","Côte d'Or","21000",{"type":40,"coordinates":138},[139,140],5.01391,47.31344,{"lat":140,"lon":139},[143],{"name":144,"role":27,"phone":11,"phoneExt":11,"email":145},"Hélène Greigert, Pr","helene.greigert@chu-dijon.fr",{"facility":147,"status":33,"city":148,"state":149,"zip":150,"country":37,"countryCode":38,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"CHU de Besançon","Besançon","Doubs","25030",{"type":40,"coordinates":152},[153,154],6.01815,47.24878,{"lat":154,"lon":153},[157],{"name":158,"role":27,"phone":159,"phoneExt":160,"email":161},"Patricia Costa, MD","03 81 66 82 27","+33","pcosta@chu-besancon.fr",{"facility":163,"status":33,"city":164,"state":165,"zip":166,"country":37,"countryCode":38,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"Centre Hospitalier Universitaire de Brest","Brest","Finistère","29069",{"type":40,"coordinates":168},[169,170],-4.48628,48.39029,{"lat":170,"lon":169},[173],{"name":174,"role":27,"phone":11,"phoneExt":11,"email":175},"Benjamin ESPINASSE","Benjamin.espinasse@chu-brest.fr",{"facility":177,"status":33,"city":178,"state":179,"zip":180,"country":37,"countryCode":38,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Clinique Rive 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RICHARD","colin.richard29@gmail.com",{"facility":102,"status":33,"city":295,"state":252,"zip":296,"country":37,"countryCode":38,"cosmosGeoPoint":297,"geoPoint":301,"contacts":302},"Six-Fours-les-Plages","83140",{"type":40,"coordinates":298},[299,300],5.82465,43.09174,{"lat":300,"lon":299},[303],{"name":304,"role":27,"phone":11,"phoneExt":11,"email":305},"Sophia BENSEDRINE","sophia.ange@wanadoo.fr",{"facility":22,"status":33,"city":307,"state":252,"zip":239,"country":37,"countryCode":38,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Toulon",{"type":40,"coordinates":309},[310,311],5.92836,43.12442,{"lat":311,"lon":310},[314],{"name":315,"role":27,"phone":11,"phoneExt":11,"email":316},"Jean-Noël POGGI","jeannoel.poggi@ch-toulon.fr",{"facility":318,"status":33,"city":319,"state":320,"zip":321,"country":37,"countryCode":38,"cosmosGeoPoint":322,"geoPoint":326,"contacts":327},"Centre Hospitalier d'Avignon","Avignon","Vaucluse","84000",{"type":40,"coordinates":323},[324,325],4.80892,43.94834,{"lat":325,"lon":324},[328],{"name":329,"role":27,"phone":11,"phoneExt":11,"email":330},"Olivier GRAS","GRAS.Olivier@ch-avignon.fr",{"facility":332,"status":33,"city":333,"state":11,"zip":334,"country":37,"countryCode":38,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"Centre Hospitalier Universitaire de Nantes","Nantes","44000",{"type":40,"coordinates":336},[337,338],-1.55336,47.21725,{"lat":338,"lon":337},[341],{"name":342,"role":27,"phone":343,"phoneExt":160,"email":344},"Olivier ESPITIA, MD","02 44 76 80 75","olivier.espitia@chu-nantes.fr",{"facility":79,"status":33,"city":346,"state":11,"zip":347,"country":37,"countryCode":38,"cosmosGeoPoint":348,"geoPoint":352,"contacts":353},"Paris","75014",{"type":40,"coordinates":349},[350,351],2.3488,48.85341,{"lat":351,"lon":350},[354],{"name":355,"role":27,"phone":11,"phoneExt":11,"email":356},"Maxime Delrue, MD","mdelrue@ghpsj.fr",{"facility":358,"status":33,"city":346,"state":11,"zip":359,"country":37,"countryCode":38,"cosmosGeoPoint":360,"geoPoint":362,"contacts":363},"Hôpital Européen Georges Pompidou","75015",{"type":40,"coordinates":361},[350,351],{"lat":351,"lon":350},[364],{"name":365,"role":27,"phone":11,"phoneExt":11,"email":366},"Guillaume GOUDOT, MD","guillaume.goudot@aphp.fr",{"type":368,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[370,372],{"name":371,"class":6},"Assistance Publique Hopitaux De Marseille",{"name":373,"class":374},"F-CRIN INNOVTE Research Network","UNKNOWN","100545703","dvt-burden-and-the-risk-of-post-thrombotic-syndrome-100545703",false,"NCT06385353","DVT Burden and the Risk of Post-thrombotic Syndrome","Baseline Ultrasound Venous Thrombosis Burden and the Risk of Post-thrombotic Syndrome in Patients With a First Acute Episode of Symptomatic Deep Vein Thrombosis of the Lower Limbs - The \"DVT-Burden\" Project -","DVT-Burden","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients with symptomatic acute deep venous thrombosis of the lower limbs confirmed by ultrasound on the criteria of venous incompressibility and direct image of the thrombus (patients with stable pulmonary embolism associated with a symptomatic deep venous thrombosis can be included)\n3. Affiliates or beneficiaries of a social security scheme.\n\nExclusion Criteria:\n\n1. Pregnant women, women in labour or breastfeeding mothers.\n2. Pulmonary embolism haemodynamically unstable defined by systolic blood pressure \\\u003C 90 mmHg or a drop in systolic blood pressure of at least 40 mmHg during at least 15 min, shock or cardiac arrest.\n3. Asymptomatic venous thrombosis.\n4. Symptomatic venous thrombosis of both lower limbs (patients with bilateral deep venous thrombosis but symptomatic on one side only can be included).\n5. History of ipsilateral or contralateral venous thrombosis of the lower limb.\n6. Fracture or orthopedic surgery of the lower limbs in the last 3 months.\n7. Dependance caused by age or secondary to a chronic affection, going from the inability to stand up or walk alone without help to bed or armchair rest over.\n8. Prophylactic or therapeutic anticoagulant treatment \\> 5 days.\n9. Expected duration of anticoagulant treatment \\\u003C 3 months (all patients must have a minimum treatment of 3 months).\n10. Patient estimated at high risk of bleeding according to investigator clinical judgment (renal, platelet, digestive, hepatic, neurological... origin) .\n11. Indication for interruption of the inferior vena cava or venous recanalisation (endovascular, thrombolysis or surgery).\n12. Refusal or inability to give written informed consent to participate in the study.\n13. Life expectancy \\\u003C 6 months.\n14. Patients under legal protection (guardianship, curatorship, etc.) or safeguard of justice.\n15. Patients taking part in a research project for venous thromboembolism that can interfere with the conduct of DVT-BURDEN research.","ALL","18 Years",{"count":386,"type":387},400,"ESTIMATED","INTERVENTIONAL",[390],"NA","Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis (DVT), with major consequences for patient quality of life and cost of management. Identifying patients at high risk of developing PTS could be useful for its prevention and may lead to more appropriate therapeutic strategies to reduce its incidence and severity.\n\nPrognostic tools for predicting risk are very useful for choosing the optimum treatment and improving patient management and are a preliminary step before developing predictive models useful for determining sensitivity to treatment. At present, although several prognostic markers and models have been proposed, it is still difficult to predict who will develop a PTS or a moderate to severe PTS. The development of PTS is multifactorial and depends largely on the extent and severity of venous obstruction which supports the theory of thrombosis burden (DVT-Burden) as a potential prognostic marker for PTS. It therefore seems important to study the association between thrombosis burden and the occurrence of PTS.\n\nThe Venous Volumetric Index or VVI (Ouriel 1999) will be used for quantifying DVT-Burden. The VVI was constructed by calculating the volume from the diameter and length of 14 venous segments from the calf veins to the inferior vena cava. The VVI has been validated for its ability to discriminate between symptomatic and asymptomatic DVT and has shown superior performance to other methods for quantifying DVT.\n\nThis study aim to assess the performance of baseline DVT-burden estimated by the VVI score on ultrasound for predicting the occurrence and the severity of PTS as assessed by the Villalta scale at 6 months.",[393],"Postthrombotic Syndrome",[395,396,397,398,399],"Venous thrombosis","Thrombus burden","Ultrasonography","Thrombus resolution","Post-thrombotic syndrome","2026-06-15",{"date":402,"type":403},"2026-06-16","ACTUAL",{"date":405,"type":403},"2024-06-05",{"date":407,"type":387},"2027-06",{"name":5,"class":6},27]