[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621826":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":19,"centralContacts":30,"locations":40,"responsibleParty":90,"collaborators":19,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":19,"eligibilityCriteria":98,"healthyVolunteers":94,"sex":99,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":19,"studyType":105,"phases":106,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":43,"whyStopped":19,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Affiliated Hospital of Nantong University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Airway resistance-guided sputum suction","EXPERIMENTAL","Investigators will continuously monitor the airway viscous resistance of patients, and initiate suctioning when the airway viscous resistance increases by ≥6 cmH₂O.",[13,14],"Procedure: The dynamics of airway resistance","Diagnostic Test: conventional suctioning",{"label":16,"type":17,"description":18,"interventionNames":19},"conventional suctioning","NO_INTERVENTION","In the control group, the decision to suction was made based on conventional clinical signs, including rhonchi and a rise in peak pressure.",null,[21,26],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":19},"PROCEDURE","The dynamics of airway resistance","Monitoring the dynamic changes in airway resistance in patients can be used to reflect the progression of pulmonary inflammation and determine the optimal timing for suctioning.",[9],{"type":27,"name":16,"description":28,"armGroupLabels":29,"otherNames":19},"DIAGNOSTIC_TEST","The timing for suctioning is determined based on clinical signs such as rhonchi and an elevated peak pressure.",[9],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":19,"email":35},"Hong-lei Wu Nursing Department, MS","CONTACT","+8613862749927","wu_honglei@163.com",{"name":37,"role":33,"phone":38,"phoneExt":19,"email":39},"xuan Qian Nursing Department, MS","+8615162763676","1660694568@qq.com",[41,60,75],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"The First Affiliated Hospital of Bengbu Medical University","RECRUITING","Bengbu","Anhui","233000","China","CN",{"type":50,"coordinates":51},"Point",[52,53],117.36083,32.94083,{"lat":53,"lon":52},[56],{"name":57,"role":33,"phone":58,"phoneExt":19,"email":59},"Yajun Li Director of the Nursing, MS","+8615955232235","liyajun1205@163.com",{"facility":61,"status":43,"city":62,"state":63,"zip":64,"country":47,"countryCode":48,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Peking Union Medical College Hospital","Beijing","Beijing Municipality","100000",{"type":50,"coordinates":66},[67,68],116.39723,39.9075,{"lat":68,"lon":67},[71],{"name":72,"role":33,"phone":73,"phoneExt":19,"email":74},"Zunzhu Li Director of the Nursing, MS","+8618612671363","1981285238@qq.com",{"facility":76,"status":43,"city":77,"state":78,"zip":79,"country":47,"countryCode":48,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"the Second Affiliated Hospital of Zhejiang University School of Medicine","Hangzhou","Zhejiang","310009",{"type":50,"coordinates":81},[82,83],120.16142,30.29365,{"lat":83,"lon":82},[86],{"name":87,"role":33,"phone":88,"phoneExt":19,"email":89},"Mei-juan Lan Director of the Nursing Department, MS","+8613757119537","lmj3632@126.com",{"type":91,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100621826","dynamic-airway-resistance--ml-guide-sputum-suction-in-ventilated-patients-100621826",false,"NCT07375667","Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients","Mechanisms of Dynamic Airway Resistance Monitoring and Machine Learning for Assessing Pulmonary Inflammation and Guiding Sputum Suction in Mechanically Ventilated Patients","Inclusion Criteria:\n\n* Clinical diagnosis of Acute Respiratory Distress Syndrome (ARDS)\n* Clinical diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)\n* Clinical diagnosis of Severe pneumonia\n\nExclusion Criteria:\n\n* Clinical diagnosis of multiple organ failure;\n* Clinical diagnosis of multiple organ bleeding;","ALL","18 Years","90 Years",{"count":103,"type":104},258,"ESTIMATED","INTERVENTIONAL",[107],"NA","Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients. However, clinical judgment on the optimal timing for suctioning currently relies primarily on physician experience, lacking scientific evidence \\[10\\]. Airway viscous resistance reflects the frictional resistance encountered by gas flow within the airways and is closely associated with airway patency. When airway secretions increase, viscous resistance undergoes dynamic changes. Therefore, analyzing these dynamic variations in viscous resistance derived from ventilator waveforms to determine the optimal suctioning timing and assess its clinical impact on the progression of pulmonary inflammation holds significant scientific value and offers new insights and methodologies for clinical practice.",[110,111,112],"Mechanical Ventilation Pressure High","Ventilator-Associated Pneumonia (VAP)","Respiratory Depression Neonatal",[114],"Airway resistance","2026-01-26",{"date":117,"type":118},"2026-01-29","ACTUAL",{"date":120,"type":118},"2025-10-30",{"date":122,"type":104},"2029-12-30",{"name":5,"class":6},3]