[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606078":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":42,"collaborators":7,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":46,"sex":52,"minAge":53,"maxAge":7,"enrollmentInfo":54,"targetDuration":7,"studyType":57,"phases":7,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":68,"whyStopped":7,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"University Hospital, Grenoble","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Christel Saint Raymond, Doctor","CHU Grenoble Alpes","STUDY_DIRECTOR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+33 4 76 76 54 53","CSaint-raymond@chu-grenoble.fr",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Hugo Vanderstraete, Resident","+33 6 78 34 08 51","hvanderstraete@chu-grenoble.fr",[23],{"facility":24,"status":7,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"CHU Grenoble-Alpes","Grenoble","Isère","38043","France","FR",{"type":31,"coordinates":32},"Point",[33,34],5.71479,45.17869,{"lat":34,"lon":33},[37,38,40],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},{"name":39,"role":15,"phone":20,"phoneExt":7,"email":21},"Hugo Vanderstraete",{"name":10,"role":41,"phone":7,"phoneExt":7,"email":7},"PRINCIPAL_INVESTIGATOR",{"type":43,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100606078","dynamic-impact-of-niv-on-diaphragmatic-ultrasound-in-patients-with-amyotrophic-lateral-sclerosis-100606078",false,"NCT07170865","Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis","Assessment of the Dynamic Impact of Non-Invasive Ventilation on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis","EchoDia","Inclusion Criteria:\n\n* Adult patient (≥18 years old)\n* Diagnosis of bulbar or spinal amyotrophic lateral sclerosis (ALS) established by a neurologist\n* Indication for non-invasive ventilation (NIV) confirmed by the referring pulmonologist for daytime and\u002For nocturnal alveolar hypoventilation\n\nExclusion Criteria:\n\n* Continuous (24-hour) non-invasive ventilation\n* Patient refusal to participate\n* Individual under legal guardianship or judicial protection","ALL","18 Years",{"count":55,"type":56},20,"ESTIMATED","OBSERVATIONAL","The goal of this pilot observational study is to learn about the dynamic impact of the non invasive ventilation on the diaphragm in patient with amyotrophic lateral sclerosis. The main question it aims to answer : can diaphragmatic ultrasound detect differences in diaphragmatic motion (diaphragmactic excursion and diaphragmatic thickening between spontaneous breathing and non-invasive ventilation ?\n\nParticipants will receive diaphragmatic ultrasound assessments both under spontaneous breathing and during non-invasive ventilation on their day hospital evaluation for ventilatory support.",[60,61],"Amyotrophic Lateral Sclerosis (ALS)","Non Invasive Ventilation (NIV)",[60,63,64,65,66,67],"Non invasive ventilation (NIV)","Diaphragmatic ultrasound","diaphragmatic excursion","ultrasound","diaphragmatic thickening","NOT_YET_RECRUITING","2025-09-04",{"date":71,"type":72},"2025-09-12","ACTUAL",{"date":74,"type":56},"2025-09-01",{"date":76,"type":56},"2026-10-15",{"name":5,"class":6},1]