[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637724":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":10,"responsibleParty":22,"collaborators":24,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":10,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":70,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":10},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adult critically ill patients admitted to the EICU",null,"Adult critically ill patients admitted to emergency intensive care units who meet the eligibility criteria will be enrolled in a single prospective observational cohort. Participants will undergo quantitative pupillometry during the first 7 days after EICU admission, or until EICU discharge or death, whichever occurs first. Clinical information, treatment data, discharge outcome, and 90-day functional outcome will be collected.",[13],{"name":14,"affiliation":5,"role":15},"Mao Zhang, MD","PRINCIPAL_INVESTIGATOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"Danni Jin, MD","CONTACT","+8615825512455","670251925@qq.com",{"type":23,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[25,27,29,31,33,35,38,40,42,44,46,48,50],{"name":26,"class":6},"Zhejiang Provincial People's Hospital",{"name":28,"class":6},"Zhejiang Provincial Tongde Hospital",{"name":30,"class":6},"Jinhua Municipal Central Hospital",{"name":32,"class":6},"Huzhou Central Hospital",{"name":34,"class":6},"Lishui Country People's Hospital",{"name":36,"class":37},"Lishui Municipal Central Hospital","OTHER_GOV",{"name":39,"class":37},"Ningbo Medical Center Lihuili Hospital",{"name":41,"class":6},"The Second Affiliated Hospital of Jiaxing University",{"name":43,"class":6},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine",{"name":45,"class":6},"The Third Affiliated Hospital of Wenzhou Medical University",{"name":47,"class":6},"Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University",{"name":49,"class":6},"People's Hospital of Quzhou",{"name":51,"class":6},"First People's Hospital of Hangzhou","100637724","dynamic-trajectories-of-pupillary-light-reflex-parameters-and-prognosis-in-critically-ill-patients-a-multicenter-prospective-cohort-study-100637724",false,"NCT07616518","Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study","PUPIL","Inclusion Criteria:\n\n1. Age 18 years or older.\n2. Admission to the emergency intensive care unit.\n3. Critically ill patients with an expected EICU stay longer than 48 hours.\n4. Written informed consent obtained from the participant or legally authorized representative.\n\nExclusion Criteria:\n\n1. Severe ocular disease, severe ocular trauma, postoperative ocular status, or other conditions that prevent reliable pupillary measurement.\n2. Known neuro-ophthalmic disorders that may affect the pupillary light reflex, such as oculomotor nerve palsy.\n3. Use of topical ophthalmic medications during the study period that may significantly affect pupillary response, when their effects cannot be accurately recorded or evaluated.\n4. Pregnancy or breastfeeding.","ALL","18 Years",{"count":62,"type":63},700,"ESTIMATED","OBSERVATIONAL","This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to emergency intensive care units. Quantitative pupillometry will be performed during the first 7 days after EICU admission. Constriction velocity will be the primary parameter for trajectory analysis, while dilation velocity, pupil diameter, constriction percentage, maximum constriction velocity, and latency will be analyzed as supplementary parameters. The study will evaluate whether these dynamic pupillary trajectories are associated with discharge outcome and 90-day functional outcome assessed by the Glasgow Outcome Scale-Extended.",[67,68,69],"Critical Illness","Pupillometry","Prognosis",[71,72,73,69,74],"Pupillary light reflex","Critically ill patients","Dynamic trajectory","Constriction Velocity","NOT_YET_RECRUITING","2026-05-24",{"date":78,"type":79},"2026-06-01","ACTUAL",{"date":81,"type":63},"2026-06-06",{"date":83,"type":63},"2026-10-13",{"name":5,"class":6}]