[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519477":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":29,"centralContacts":33,"locations":40,"responsibleParty":56,"collaborators":20,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":20,"maxAge":67,"enrollmentInfo":68,"targetDuration":20,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":43,"whyStopped":20,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University Hospital, Rouen","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"All patients","All patients included will be followed for 1 year, every 3 months",[12,13,14],"Other: Blood sample","Other: Expectoration","Other: Nasopharyngeal swab",[16,21,25],{"type":6,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"Blood sample","An additionnal volume of blood will be collected at inclusion and at each follow-up visit",[9],null,{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":20},"Expectoration","Expectoration will be collected at inclusion and at each follow-up visit",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":20},"Nasopharyngeal swab","A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum",[9],[30],{"name":31,"affiliation":5,"role":32},"PETAT Hortense","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"David Mallet","CONTACT","02 32 88 82 65","+33","secretariat.DRC@chu-rouen.fr",[41],{"facility":42,"status":43,"city":44,"state":20,"zip":20,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Rouen University Hospital","RECRUITING","Rouen","France","FR",{"type":48,"coordinates":49},"Point",[50,51],1.09932,49.44313,{"lat":51,"lon":50},[54],{"name":55,"role":36,"phone":20,"phoneExt":20,"email":20},"Hortense PETAT",{"type":57,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100519477","dynamics-of-the-upper-and-lower-airway-respiratory-microbiomes-associated-with-severe-infant-asthma-100519477",false,"NCT06044051","Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma","Dynamique Des Microbiomes Respiratoires Des Voies supérieures et inférieures associée à l'Asthme sévère Des Nourrissons","Microbiosthme","Inclusion Criteria:\n\n* Infants less than 24 months old\n* Follow-up by a pneumo-pediatrician for severe asthma in infants\n* Requiring etiological investigations and assessment of severity in day hospitalization, including bronchial fibroscopy (HAS 2009)\n* Parent informed of the research and having signed consent\n\nExclusion Criteria:\n\n* Prematurity \\\u003C32 WA\n* Congenital heart disease with significant left to right shunt\n* Chronic respiratory disease other than infant asthma (cystic fibrosis, bronchiolitis obliterans)\n* Antibiotic therapy in progress or administered the seven days preceding the date of inclusion (day hospitalization)\n* Refusal of bronchial fibroscopy","ALL","24 Months",{"count":69,"type":70},100,"ESTIMATED","INTERVENTIONAL",[73],"NA","Nature of potential dysbiosis, interrelation of the different microbiomes of the respiratory tract, and potential role of the immune system in the pathogenesis of severe asthma in infants, and its evolution under treatment.\n\nExploring and understanding these data is to improve patient care and discover new therapeutic targets.\n\nThe aim is to open up prospects for therapeutic studies, such as the use of azithromycin as an immunomodulator in infant asthma, the results of which are discordant.",[76,77],"Asthma in Children","Asthma",[79,80],"microbiosme","Asthma in infant","2026-02-13",{"date":83,"type":84},"2026-02-17","ACTUAL",{"date":86,"type":84},"2023-09-26",{"date":88,"type":70},"2026-09-26",{"name":5,"class":6},1]