[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614616":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":23,"locations":31,"responsibleParty":47,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":68,"whyStopped":10,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"ARDS secondary to sepsis, requiring intubation and mechanical ventilation",null,"Participants are adult ICU patients diagnosed with ARDS secondary to sepsis, requiring intubation and mechanical ventilation. Because the great majority will be sedated or unconscious, informed consent will be sought from legally authorized representatives. This population is particularly prone to adverse outcomes, making biological and mechanical profiling both valuable and clinically meaningful.",[13,17,20],{"name":14,"affiliation":15,"role":16},"Maria Martínez Pla, MD","SODIR (Shock, Disfunció Orgànica i Ressuscitació)","PRINCIPAL_INVESTIGATOR",{"name":18,"affiliation":15,"role":19},"Luis Chiscano Camon, MD, PhD","STUDY_DIRECTOR",{"name":21,"affiliation":15,"role":22},"Luis Morales Quinteros, MD, PhD","STUDY_CHAIR",[24,28],{"name":14,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","+34636602073","maria.martinezpla@vallhebron.cat",{"name":18,"role":25,"phone":29,"phoneExt":10,"email":30},"+34 659584804","luissilvestre.chiscano@vallhebron.cat",[32],{"facility":33,"status":10,"city":34,"state":10,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Hospital Universitari Vall d'Hebron","Barcelona","08035","Spain","ES",{"type":39,"coordinates":40},"Point",[41,42],2.15899,41.38879,{"lat":42,"lon":41},[45],{"name":14,"role":25,"phone":46,"phoneExt":10,"email":27},"+34 636602073",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100614616","early-biological-and-mechanical-profiling-in-sepsis-associated-ards-100614616",false,"NCT07281911","Early Biological and Mechanical Profiling in Sepsis-Associated ARDS","Characterization of Early Biological and Mechanical Profiles in Sepsis-Associated ARDS for Studying Compartamentalization (Serial Bronchoalveolar Lavage and Plasma Biomarkers) to Identify Inflammatory and Hybrid Subphenotypes","EARLY-SARDS","Inclusion Criteria:\n\n* Age ≥18\n* ARDS diagnosis per Berlin definition\n* Sepsis per Sepsis-3 criteria\n* Invasive mechanical ventilation\n* Expected to remain intubated ≥72 hours\n* Consent from surrogate\n\nExclusion Criteria:\n\n* Contraindications to bronchoscopy\u002FBAL\n* Refractory hemodynamic instability\n* Pregnancy\n* Pulmonary transplant patients\n* Surrogate declines participation","ALL","18 Years",{"count":60,"type":61},180,"ESTIMATED","OBSERVATIONAL","Sepsis-associated acute respiratory distress syndrome (ARDS) is one of the deadliest and most biologically heterogeneous forms of respiratory failure. Despite uniform diagnostic criteria, patients with septic ARDS show wide variability in inflammatory intensity, alveolar epithelial and endothelial injury, alveolar fluid composition, ventilatory mechanical properties, and clinical evolution. Early identification of these differences may enable better prognostication and more precise treatment.\n\nThis prospective observational study aims to deeply characterize the earliest phases of septic ARDS by integrating serial bronchoalveolar lavage (BAL) at 0, 24 and 72 hours with parallel plasma biomarker profiling and detailed mechanical ventilation data. This design captures the evolving biological and physiological landscape of septic ARDS during its most dynamic window. The central goal is to identify systemic, alveolar, and hybrid bio-mechano-inflammatory subphenotypes that can inform personalized approaches to support, risk stratification, and future interventional trials.",[65,66,67],"Acute Hypoxemic Respiratory Failure","Sepsis","ARDS (Acute Respiratory Distress Syndrome)","NOT_YET_RECRUITING","2025-12-02",{"date":71,"type":72},"2025-12-15","ACTUAL",{"date":74,"type":61},"2026-03-01",{"date":76,"type":61},"2027-11-01",{"name":5,"class":6},1]