[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100519841":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":23,"locations":29,"responsibleParty":62,"collaborators":66,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":18,"enrollmentInfo":81,"targetDuration":18,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Medisch Spectrum Twente","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early cessation of sedation and TTM","EXPERIMENTAL","Early cessation of sedation and targeted temperature management (TTM), with subsequent weaning from mechanical ventilation if appropriate (intervention group).",[13],"Other: Early cessation of sedation and TTM",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Care","NO_INTERVENTION","Standard care, including sedation and targeted temperature management (TTM) for at least 24-48 hours (control group).",null,[20],{"type":6,"name":9,"description":21,"armGroupLabels":22,"otherNames":18},"Early cessation of sedation and TTM, with subsequent weaning from mechanical ventilation if appropriate",[9],[24],{"name":25,"role":26,"phone":27,"phoneExt":18,"email":28},"Marleen C. Tjepkema-Cloostermans, PhD","CONTACT","0031 534872850","m.tjepkema-cloostermans@mst.nl",[30,49],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Rijnstate hospital","RECRUITING","Arnhem","Gelderland","6815AD","Netherlands","NL",{"type":39,"coordinates":40},"Point",[41,42],5.91111,51.98,{"lat":42,"lon":41},[45],{"name":46,"role":26,"phone":47,"phoneExt":18,"email":48},"Jeannette Hofmeijer, Prof.","+31 880058888","jhofmeijer@rijnstate.nl",{"facility":5,"status":32,"city":50,"state":51,"zip":52,"country":36,"countryCode":37,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Enschede","Overijssel","7500KA",{"type":39,"coordinates":54},[55,56],6.89583,52.21833,{"lat":56,"lon":55},[59],{"name":60,"role":26,"phone":61,"phoneExt":18,"email":28},"Marleen C. Tjepkema-Cloostermans+, PhD","+31 534872850",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Marleen Tjepkema-Cloostermans","Technical Physician Specialist",[67,69],{"name":68,"class":6},"Rijnstate Hospital",{"name":70,"class":6},"University of Twente","100519841","early-cessation-of-sedation-and-ttm-in-patients-with-a-favourable-eeg-after-cardiac-arrest-100519841",false,"NCT06048796","Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest","Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest: a Feasibility and Safety Study","SELECT","Inclusion Criteria:\n\n* Patients after cardiac arrest admitted to the ICU for treatment with sedation, TTM and mechanical ventilation.\n* Age 18 years or older.\n* Continuous EEG measurement started within 12 hours after cardiac arrest.\n* Favourable EEG pattern within 12 hours after arrest, defined as a continuous background pattern (NVN, 2019; Ruijter et al., 2019).\n* Possibility to stop sedative treatment within three hours after identification of a favourable EEG pattern.\n* Written informed consent (deferred).\n\nExclusion Criteria:\n\n* A known history of another medical condition with limited life expectancy (\\\u003C6 months).\n* Any progressive brain illness, such as a brain tumour or neurodegenerative disease.\n* Pre-admission Glasgow Outcome Scale Extended score of 4 or lower.\n* Reason other than neurological condition to continue sedation and\u002For ventilation.\n* Follow-up impossible due to logistic reasons.","ALL","18 Years",{"count":82,"type":83},40,"ESTIMATED","INTERVENTIONAL",[86],"NA","The objective of this study is to estimate the feasibility and safety of early weaning from ICU treatment in patients after cardiac arrest and an early (\\\u003C 12 h) favourable EEG pattern (indicating no or mild postanoxic encephalopathy).",[89,90],"Hypoxia-Ischemia, Brain","Heart Arrest",[92,93],"EEG","targeted temperature management (TTM)","2024-05-10",{"date":96,"type":97},"2024-05-13","ACTUAL",{"date":99,"type":97},"2024-03-12",{"date":101,"type":83},"2026-10",{"name":5,"class":6},2]