[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100316634":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":45,"collaborators":47,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Montefiore Medical Center","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"IUGR infants",null,"Intrauterine growth restricted infants will be enrolled. There are no interventions.",{"label":13,"type":10,"description":14,"interventionNames":10},"AGA infants","Appropriate for gestational age infants will be enrolled. There are no interventions.",[16],{"name":17,"affiliation":18,"role":19},"Sandra Reznik, MD","Montefiore Medical Center\u002FAlbert Einstein College of Medicine","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","718-904-2947","sreznik@montefiore.org",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Jack D. Weiler Hospital","RECRUITING","The Bronx","New York","10461","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-73.86641,40.84985,{"lat":38,"lon":37},[41],{"name":42,"role":22,"phone":43,"phoneExt":10,"email":44},"Mamta Fuloria, MD","718-904-4105","mfuloria@montefiore.org",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48,51,53,56,58,60],{"name":49,"class":50},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",{"name":52,"class":6},"Icahn School of Medicine at Mount Sinai",{"name":54,"class":55},"Hackensack Meridian Health Center for Discovery and Innovation","UNKNOWN",{"name":57,"class":6},"University of California, San Francisco",{"name":59,"class":6},"University of Wisconsin, Madison",{"name":61,"class":55},"Gencove","100316634","early-childhood-obesity-programming-by-intrauterine-growth-restriction-100316634",false,"NCT03402139","Early Childhood Obesity Programming by Intrauterine Growth Restriction","Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction","Mother-infant pairs will be recruited for this study.\n\nInclusion Criteria:\n\n* Healthy singleton term intrauterine growth restricted (IUGR) and appropriate for gestational age (AGA) infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center. Infants will be classified as IUGR if birth weight is \\\u003C10th percentile for gestational age and gender based on World Health Organization (WHO) growth curves. Infants will be classified as AGA if birth weight percentile is \\>10th and \\\u003C90th percentile\n* Reproductive age women, healthy enough to achieve pregnancy\n* Deliver a single healthy live term infant at ≥37 weeks' gestational age (GA)\n* All patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines\n\nExclusion Criteria:\n\n* Multiple gestation\n* Maternal depression\n* Maternal renal disease\n* History of maternal smoking in the 2nd and 3rd trimester of pregnancy\n* Maternal gestational diabetes \u002F Type 2 Diabetes (T2D)\n* Preterm birth (less than 37 weeks' gestation)\n* Known chromosomal or congenital anomaly\n* Infants in extremis\n* Low Apgar scores (Apgar score \\\u003C7 at 5 minutes of age)\n* Known congenital bacterial or non-bacterial infections\n* Known inborn errors of metabolism",true,"ALL","1 Hour","24 Months",{"count":74,"type":75},400,"ESTIMATED","OBSERVATIONAL","The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.",[79,80],"Childhood Obesity","Epigenetics","2025-09-08",{"date":83,"type":84},"2025-09-15","ACTUAL",{"date":86,"type":84},"2018-09-01",{"date":88,"type":75},"2028-03",{"name":5,"class":6},1]