[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535553":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":39,"centralContacts":46,"locations":54,"responsibleParty":70,"collaborators":10,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":10,"enrollmentInfo":82,"targetDuration":10,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":10,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University Hospital Southampton NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients presenting to the Emergency Department with suspected sepsis",null,"Patients who present with potential sepsis. This is characterised by their illness suspected to be from an infection and significantly unwell defined by one of two scoring systems, either the National Early Warning Score or quick Sequential Organ Failure Assessment",[13,14,15,16],"Diagnostic Test: Measuring tissue oxygenation","Diagnostic Test: Procalcitonin","Diagnostic Test: Mid-regional proadrenomedullin","Diagnostic Test: Hand-held video microscope",[18,23,29,35],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Measuring tissue oxygenation","Measuring oxygen content of arteries, capillaries and veins",[9],{"type":19,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"Procalcitonin","Blood test",[9],[28],"PCT",{"type":19,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Mid-regional proadrenomedullin","Blood test looking at inflammation in the body",[9],[34],"MR-proADM",{"type":19,"name":36,"description":37,"armGroupLabels":38,"otherNames":10},"Hand-held video microscope","A handheld video microscope that looks at blood flow through the capillaries of the tongue",[9],[40,43],{"name":41,"affiliation":5,"role":42},"Ahilanandan Dushianthan, PhD","STUDY_DIRECTOR",{"name":44,"affiliation":5,"role":45},"James N Ward, BM","PRINCIPAL_INVESTIGATOR",[47,51],{"name":44,"role":48,"phone":49,"phoneExt":10,"email":50},"CONTACT","+447881967336","wardj@doctors.org.uk",{"name":41,"role":48,"phone":52,"phoneExt":10,"email":53},"+447903943418","a.dushianthan@soton.ac.uk",[55],{"facility":5,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Southampton","Hampshire","SO16 6YD","United Kingdom","UK",{"type":63,"coordinates":64},"Point",[65,66],-1.40428,50.90395,{"lat":66,"lon":65},[69],{"name":44,"role":48,"phone":10,"phoneExt":10,"email":10},{"type":71,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100535553","early-detection-of-at-risk-septic-patients-100535553",false,"NCT06253325","Early Detection of At-risk Septic Patients","An Observational Pilot Study for the Multi-Modality Risk Prediction and Early Identification of Critically Ill Septic Patients in the Emergency Department","MMICS","Inclusion Criteria:\n\n1. Differential diagnosis which includes infection\n2. Change in the quick Sequential Organ Failure Assessment (qSOFA) ≥2 or National Early Warning Score 2 (NEWS2) score ≥5\n3. Aged ≥18 years\n\nExclusion Criteria:\n\n1. Traumatic injury\n2. Rockwood frailty score ≥6\n3. Critical care therapy previously believed to not be in patient's best interests\n4. Critical care therapies-initiated pre-hospital. Critical care therapies defined as:\n\n   4.1 Mechanical ventilation 4.2 Vasopressor\u002Finotrope therapy 4.3 Sedation or a general anaesthetic 4.4 Pre-hospital transfusion of blood products 4.5 Extra-corporeal support\n5. Advanced directive refusing critical care therapies.\n6. Acute cardiac failure\n7. Active gastrointestinal bleed\n8. Massive pulmonary embolism\n9. ICU admission declined by critical care team\n10. Treated in an acute hospital \\\u003C6 hours before presentation to the Emergency Department","ALL","18 Years",{"count":83,"type":84},60,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to determine whether additional investigations used in other parts of healthcare can be used in the Emergency Department to identify critically ill patients quicker than usual care.",[88],"Sepsis","2024-11-27",{"date":91,"type":92},"2024-12-02","ACTUAL",{"date":94,"type":92},"2024-01-12",{"date":96,"type":84},"2025-08-06",{"name":5,"class":6},1]