[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100390972":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":33,"responsibleParty":63,"collaborators":10,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":87,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Institut Investigacio Sanitaria Pere Virgili","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Familial hypercholesterolaemia children",null,"FH diagnostic criteria were as follows: a positive genetic test or, if no genetic test results were available, LDL-C \\>160 mg\u002FdL and one parent with a DLCN score \\>8.",[13],"Other: lifestyle assessment",{"label":15,"type":10,"description":16,"interventionNames":17},"Unaffected children","The children evaluated for suspected FH who did not meet the FH criteria were included in the non-FH control group",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"lifestyle assessment","A semi-quantitative assessment of the consumption of different food groups will be carried out using a frequency questionnaire validated by the Spanish population27. This questionnaire consists of 137 food items and will be obtained by the dietitian of our Unit (see annex).\n\nThe child population and\u002For their parents will be instructed on how to fill the data in the food diary for a period of 3 days, in order to be able to analyse the nutritional composition of the intake and the effect on the lipid profile. The first food register, will be obtained at the collection visit before starting any type of treatment. Another food diary will be included after one year.\n\nPhysical activity will be collected from the Minnesota Test and we will ask about the consumption of tobacco.",[9,15],[24],{"name":25,"affiliation":5,"role":26},"Luis Masana, MD, PhD","STUDY_DIRECTOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Núria Plana, MD, PhD","CONTACT","+34977300310","nplana@grupsagessa.cat",[34,55],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Hospital Universitari Sant Joan de Reus","RECRUITING","Reus","Tarragona","43440","Spain","ES",{"type":43,"coordinates":44},"Point",[45,46],1.10687,41.15612,{"lat":46,"lon":45},[49,52],{"name":29,"role":30,"phone":50,"phoneExt":51,"email":32},"+34977310300","55701",{"name":25,"role":30,"phone":53,"phoneExt":10,"email":54},"+34977759371","luis.masana@urv.cat",{"facility":56,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"Hospital Universitari Sant Joan",{"type":43,"coordinates":58},[45,46],{"lat":46,"lon":45},[61,62],{"name":29,"role":30,"phone":50,"phoneExt":51,"email":32},{"name":25,"role":30,"phone":53,"phoneExt":10,"email":54},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Nuria Plana","Principal Investigator","100390972","early-detection-of-familial-hypercholesterolemia-in-children-100390972",false,"NCT04370899","Early Detection of Familial Hypercholesterolemia in Children","Early Detection of Familial Hypercholesterolemia in Children in Tarragona Province","DECOPIN","Inclusion Criteria:\n\n* Children between 2 and 18 years of age.\n* LDL-C level above 135 mg\u002FdL\n* Previously, the pediatrician will have discarded secondary causes (hypercholesterolaemia such as hypothyroidism, nephrotic syndrome, diabetes, renal insufficiency).\n\nAfter confirmation that one of the parents has a genetic mutation (Lipoxip\u002FLiponext) or clinical diagnosis (DLCN ≥ 8), the child will be studied. The progenitor with hypercholesterolemia will be considered as an index case, in this way we will demonstrate the vertical transmission of the genetic disease.\n\nExclusion Criteria:\n\n* The child population under 2 and over the age of 18 and children.\n* Children with high cholesterol but by secondary causes.","ALL","2 Years","18 Years",{"count":79,"type":80},400,"ESTIMATED","OBSERVATIONAL","Heterozigous FH is an underdiagnosed disease in the paediatric population. Its early detection, would allow us to initiate lifestyle therapeutical changes and early pharmacological therapy if necessary. This is a key fact to reduce atherosclerosis progression and cardiovascular risk in adulthood. Moreover, it will allow, detecting the first and second degree affected relatives.",[84,85,86],"Familial Hypercholesterolemia","Familial Hypercholesterolemia - Heterozygous","Familial Hypercholesterolemia - Homozygous",[84,88,89,20,90,91],"Childhood","cardiovascular risk","genetic disorder","LDL cholesterol","2025-04-17",{"date":94,"type":95},"2025-04-18","ACTUAL",{"date":97,"type":95},"2013-03-14",{"date":99,"type":80},"2030-07-01",{"name":5,"class":6},2]