[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620689":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":25,"responsibleParty":42,"collaborators":44,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":49,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University Hospital Olomouc","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Parkinson disease cohort",null,"PD patients cohort will consist of 100 patients with parkinson disease aged between 18-85 years, with, with a balanced sex distribution to ensure representativeness and reduce gender bias. The target sample size (N = 100) has been chosen to provide adequate statistical power to detect moderate to strong correlations between clinical and paraclinical measures , we also want to distribute patients regularly across all those ages. Participants with premorbid cognitive impairment or those not clinically stable during the study period will be excluded, also participants with a Hoehn and Yahr stage greater than 4 will be excluded.",{"label":13,"type":10,"description":14,"interventionNames":10},"Multiple sclerosis cohort","Multiple sclerosis patient cohort will consist of 100 patients with multiple sclerosis. aged between 18-85 years, with, with a balanced sex distribution to ensure representativeness and reduce gender bias. The target sample size (N = 100) has been chosen to provide adequate statistical power to detect moderate to strong correlations between clinical and paraclinical measures , we also want to distribute patients regularly across all those ages. Participants with premorbid cognitive impairment or those not clinically stable during the study period will be excluded also an Expanded Disability Status Scale (EDSS) score above 6.5 will serve as an exclusion criterion.",[16,21],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Dalibor Zimek, M.D.","CONTACT","+420 702 048 036","Dalibor.Zimek@fnol.cz",{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},"Ladislav Stanke, Ph.D.","+420 588 443 713","Ladislav.Stanke@fnol.cz",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"University hospital Olomouc","RECRUITING","Olomouc","Olomouc Region","779 00","Czechia",{"type":34,"coordinates":35},"Point",[36,37],17.25175,49.59552,{"lat":37,"lon":36},[40,41],{"name":22,"role":18,"phone":23,"phoneExt":10,"email":24},{"name":17,"role":18,"phone":19,"phoneExt":10,"email":10},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45],{"name":46,"class":6},"Palacky University","100620689","early-detection-of-selected-neuropathologies-in-motor-vehicle-drivers-100620689",false,"NCT07360886","Early Detection of Selected Neuropathologies in Motor Vehicle Drivers","NeuroDrive","Inclusion Criteria:\n\n* Person after signing informed consent.\n* After meeting the valid diagnostic criteria for the given neurological diagnosis.\n* Possession of a valid driver's license and proof of active driving.\n* Age limit 18 - 85 years.\n\nExclusion Criteria:\n\n* Proven diagnosis of dementia based on a current psychological examination (MMSE 24 points or less).\n* Diagnosis of a disease or condition that, according to Czech Law. No. 277\u002F2004 Coll., on medical fitness to drive motor vehicles, as amended (especially Law No. 204\u002F2025 Coll.), prevents or significantly limits the ability to drive a motor vehicle safely (e.g. dementia, epilepsy, severe disorders of consciousness).\n* Age less than 18 years.\n* Age more than 85 years.\n* In the second cohort (patients with Multiple Sclerosis), proven and treated relapse in the last 6 weeks before inclusion in the study.\n* In the MS cohort, current EDSS \\> 6.5 points.\n* For the PD cohort, the current Hoehn and Yahr scale score is greater than or equal to 4.\n* For both cohorts, evidence of parainfectious deterioration as demonstrated by laboratory testing.","ALL","18 Years","85 Years",{"count":58,"type":59},200,"ESTIMATED","OBSERVATIONAL","This study aims to develop accessible methods for the early detection of selected neuropathologies in drivers, focusing on multiple sclerosis and Parkinson's disease. The primary objective is to identify clinical tests that correlate with outcomes from the Vienna Test System (VTS), thereby enabling early diagnosis without the need for complex neurological or neuropsychological assessments. Findings could improve the effectiveness of routine driver medical check-ups and inform future modifications to Czech traffic law to enhance road safety.",[63,64],"Multiple Sclerosis","Parkinson Disease",[66,67,68,69,70],"Neurology","Psychology","Traffic psychology","Vienna Test System","Driving abilities","2026-01-13",{"date":73,"type":74},"2026-01-22","ACTUAL",{"date":76,"type":74},"2025-11-01",{"date":78,"type":59},"2028-12-31",{"name":5,"class":6},1]