[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637629":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":31,"collaborators":10,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":39,"eligibilityCriteria":40,"healthyVolunteers":35,"sex":41,"minAge":42,"maxAge":10,"enrollmentInfo":43,"targetDuration":10,"studyType":46,"phases":10,"briefSummary":47,"conditions":48,"keywords":10,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":62},{"fullName":5,"class":6},"University Hospital, Strasbourg, France","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients admitted to intensive care for septic shock",null,"This pilot cohort is based on the demonstration that the increase in fluorescence of neutrophils, whether isolated or integrated into an AI model, is predictive of DIC and constitutes an early and reliable diagnostic marker of septic DIC.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Julie HELMS, Professor","CONTACT","+33 3 69 55 13 69","julie.helms@chru-strasbourg.fr",[19],{"facility":20,"status":10,"city":21,"state":10,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":10},"The University Hospitals of Strasbourg, Intensive Care Medicine Department - New Civil Hospital","Strasbourg","67098","France","FR",{"type":26,"coordinates":27},"Point",[28,29],7.74553,48.58392,{"lat":29,"lon":28},{"type":32,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100637629","early-diagnosis-of-septic-dic-100637629",false,"NCT07630415","EARLY DIAGNOSIS OF SEPTIC DIC","OPTIMIZATION AND CLINICAL VALIDATION OF AN INNOVATIVE TEST FOR THE EARLY DIAGNOSIS OF SEPTIC DIC VIA AN AUTOMATION INTEGRATING ARTIFICIAL INTELLIGENCE","EASY-DIC","Inclusion Criteria:\n\n* Male or female ≥ 18 years old\n* Patient admitted to intensive care for septic shock\n* Patient affiliated with a social security scheme or having rights\n* No objection from the patient or a relative in case the patient is not able to express consent, or inclusion under emergency procedure in case the patient is not able to express their opinion and no relative of the patient is reachable.\n\nExclusion Criteria:\n\n* Moribund patient on the day of inclusion\n* Child-Pugh C cirrhosis\n* Neutropenia (\\\u003C500 mm3)\n* Patient under legal protection\n* Patient under guardianship or curatorship\n* Pregnancy\u002F Breastfeeding","ALL","18 Years",{"count":44,"type":45},492,"ESTIMATED","OBSERVATIONAL","Disseminated Intravascular Coagulation is a severe complication of septic shock, associated with high mortality, whose diagnosis relies on complex scores that are rarely used in practice. Preliminary studies have shown that increased neutrophil fluorescence is associated with Disseminated Intravascular Coagulation and could reflect NETosis, a key mechanism of immunothrombosis. This study aims to validate neutrophil fluorescence measured on the SthemA 801 analyzer, alone or integrated into an artificial intelligence model, as an early, reliable, and routinely usable biomarker for the diagnosis of septic Disseminated Intravascular Coagulation.",[49,50,51],"Disseminated Intravascular Coagulation (DIC)","Reanimation","Septic Shock","NOT_YET_RECRUITING","2026-06-01",{"date":55,"type":56},"2026-06-05","ACTUAL",{"date":58,"type":45},"2026-06-15",{"date":60,"type":45},"2029-01-15",{"name":5,"class":6},1]