[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610816":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":31,"locations":40,"responsibleParty":93,"collaborators":96,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":104,"sex":110,"minAge":111,"maxAge":18,"enrollmentInfo":112,"targetDuration":18,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":42,"whyStopped":18,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Unidade Local de Saúde de Coimbra, EPE","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Doppler-guided early mobilization","EXPERIMENTAL","Patients with ischemic stroke will be mobilized based on the results of carotid and transcranial Doppler ultrasound examinations. If significant hemodynamic alterations are identified, such as stenosis ≥70% or intracranial occlusions, mobilization will be gradually introduced up to the 5th-7th day post-event. In the absence of such alterations, mobilization will begin immediately, with out-of-bed transfer to a chair within 48 hours and gait training, if clinically feasible.",[13],"Procedure: Doppler-guided early mobilization",{"label":15,"type":16,"description":17,"interventionNames":18},"Standard Care Mobilization - Control Group","NO_INTERVENTION","Patients with ischemic stroke are mobilized according to standard clinical practice, without considering hemodynamic assessment results from Doppler ultrasound. Mobilization is introduced gradually, guided by the patient's clinical tolerance.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"PROCEDURE","Individualized early mobilization after ischemic stroke, guided by hemodynamic assessment using carotid and transcranial Doppler ultrasound. The type and timing of mobilization are adjusted according to the presence of significant hemodynamic alterations.",[9],[25,29],{"name":26,"affiliation":27,"role":28},"Joao Sargento Freitas, MD, PhD","Unidade Local de Saude de Coimbra","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":27,"role":30},"STUDY_DIRECTOR",[32,36],{"name":26,"role":33,"phone":34,"phoneExt":18,"email":35},"CONTACT","+351 239 400 400","joaosargentofreitas@ulscoimbra.min-saude.pt",{"name":37,"role":33,"phone":34,"phoneExt":38,"email":39},"Clinical Trials Unit - Coimbra Academic Clinical Center CTU-CACC Unidade Local de Saude de Coimbra","8408","ctu-cacc@ulscoimbra.min-saude.pt",[41,57,76],{"facility":27,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"RECRUITING","Coimbra","Coimbra District","3004-561","Portugal","PT",{"type":49,"coordinates":50},"Point",[51,52],-8.41996,40.20686,{"lat":52,"lon":51},[55,56],{"name":37,"role":33,"phone":34,"phoneExt":38,"email":39},{"name":26,"role":28,"phone":18,"phoneExt":18,"email":18},{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":46,"countryCode":47,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Unidade Local de Saúde de Santa Maria","NOT_YET_RECRUITING","Lisbon","Lisbon District","1649-028",{"type":49,"coordinates":64},[65,66],-9.1498,38.72509,{"lat":66,"lon":65},[69,73,75],{"name":70,"role":33,"phone":71,"phoneExt":18,"email":72},"Ana Catarina Fonseca, MD","+351 21 780 5000","contactcenter@ulssm.min-saude.pt",{"name":74,"role":33,"phone":18,"phoneExt":18,"email":18},"Clinical Trials Unit - Coimbra Academic Clinical Center CTU-CACC",{"name":70,"role":28,"phone":18,"phoneExt":18,"email":18},{"facility":77,"status":59,"city":78,"state":79,"zip":80,"country":46,"countryCode":47,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Unidade Local de Saúde de São João","Porto","Porto District","4200-319",{"type":49,"coordinates":82},[83,84],-8.61097,41.1485,{"lat":84,"lon":83},[87,91,92],{"name":88,"role":33,"phone":89,"phoneExt":18,"email":90},"Pedro Miguel Castro, MD","+351 225 512 100","pedromacc@gmail.com",{"name":74,"role":33,"phone":18,"phoneExt":18,"email":18},{"name":88,"role":28,"phone":18,"phoneExt":18,"email":18},{"type":28,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"João Sargento Freitas","Principal Investigator, MD, PhD, Stroke Unit Coordinator",[97,100],{"name":98,"class":99},"Unidade Local de Saúde São João","OTHER_GOV",{"name":101,"class":99},"Unidade Local de Saúde Santa Maria","100610816","early-doppler-assisted-mobilization-in-adults-after-acute-ischemic-stroke-100610816",false,"NCT07232498","Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke","Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial","DOP-MOBILIZE","Inclusion Criteria:\n\n* Patients diagnosed with ischemic stroke aged 18 years or older;\n* Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours;\n* Informed consent obtained from the patient or legal representative.\n\nExclusion Criteria:\n\n* Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4;\n* Diagnosis of Transient Ischemic Attack (TIA);\n* Severe hemodynamic instability, defined as:\n* Systolic blood pressure \\\u003C 100 mmHg or \\> 220 mmHg;\n* Peripheral oxygen saturation \\\u003C 92%;\n* Heart rate \\\u003C 40 or \\> 112 beats per minute;\n* Body temperature \\> 38.5°C;\n* Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale \\\u003C 10);\n* Patients who underwent neurosurgical intervention within the past 30 days;\n* Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer);\n* Requirement for continuous monitoring or continuous intravenous drug infusion;\n* Acute deep vein thrombosis\u002Fpulmonary embolism.","ALL","18 Years",{"count":113,"type":114},1300,"ESTIMATED","INTERVENTIONAL",[117],"NA","Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.\n\nIn this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.",[120],"Arterial Ischemic Stroke",[120,122,123,124,125,126],"Early mobilization","mRS","Transcranial doppler ultrasound","Neurology","Hemodynamics","2026-05-20",{"date":129,"type":130},"2026-05-26","ACTUAL",{"date":132,"type":130},"2025-06-04",{"date":134,"type":114},"2027-12",{"name":5,"class":6},3]