[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603978":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":34,"responsibleParty":115,"collaborators":18,"id":117,"slug":118,"hasResults":119,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":119,"sex":125,"minAge":126,"maxAge":18,"enrollmentInfo":127,"targetDuration":18,"studyType":130,"phases":131,"briefSummary":133,"conditions":134,"keywords":145,"overallStatus":37,"whyStopped":18,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},{"fullName":5,"class":6},"Insel Gruppe AG, University Hospital Bern","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early exercise-based rehabilitation (EBR)","ACTIVE_COMPARATOR","Early 6- to 8-week, center-based EBR program, and 2 educational sessions",[13],"Other: Exercise-based rehabilitation program",{"label":15,"type":16,"description":17,"interventionNames":18},"usual care (no rehabilitation)","NO_INTERVENTION","Participants in the control group will receive usual care (i.e., no exercise-based rehabilitation program)",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Exercise-based rehabilitation program","Participants in the intervention group will receive a patient-tailored early (i.e., within 4 weeks of PE diagnosis) EBR program, comprising 16-18 sessions of supervised aerobic exercise and resistance\u002Fstrength training at local outpatient rehabilitation centers, along with 2 PE-related educational sessions at 2 and 6 weeks of rehabilitation. Participants will receive comprehensive information on the purpose of EBR and each of its components, reassurance on its safety, and education on self-monitoring. Furthermore, physiotherapists will tailor the training based on specific capabilities, focusing on areas of weakness.",[9],[25],{"name":26,"affiliation":27,"role":28},"Tobias Tritschler, Prof. Dr. med., MSc","Inselspital, Universitätsspital Bern","PRINCIPAL_INVESTIGATOR",[30],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},"CONTACT","+41 (0)31 632 01 46","tobias.tritschler@insel.ch",[35,52,65,76,89,102],{"facility":36,"status":37,"city":38,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Cantonal Hospital Aarau","RECRUITING","Aarau","Switzerland","CH",{"type":42,"coordinates":43},"Point",[44,45],8.04422,47.39254,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":50,"phoneExt":18,"email":51},"Philipp Schütz, Prof. Dr. med.","+41 (0)62 838 95 24","philipp.schuetz@ksa.ch",{"facility":53,"status":37,"city":54,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Cantonal Hospital Baden","Baden",{"type":42,"coordinates":56},[57,58],8.30592,47.47333,{"lat":58,"lon":57},[61],{"name":62,"role":31,"phone":63,"phoneExt":18,"email":64},"Maria Wertli, Prof. Dr. med.","+41 (0)56 486 25 02","maria.wertli@ksb.ch",{"facility":66,"status":37,"city":67,"state":18,"zip":68,"country":39,"countryCode":40,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Inselspital, Bern University Hospital","Bern","3010",{"type":42,"coordinates":70},[71,72],7.44744,46.94809,{"lat":72,"lon":71},[75],{"name":26,"role":31,"phone":32,"phoneExt":18,"email":33},{"facility":77,"status":37,"city":78,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Geneva University Hospitals","Geneva",{"type":42,"coordinates":80},[81,82],6.14569,46.20222,{"lat":82,"lon":81},[85],{"name":86,"role":31,"phone":87,"phoneExt":18,"email":88},"Marc Righini, Prof. Dr. med.","+41 (0)22 372 92 94","marc.righini@hug.ch",{"facility":90,"status":37,"city":91,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Lausanne University Hospital","Lausanne",{"type":42,"coordinates":93},[94,95],6.63282,46.516,{"lat":95,"lon":94},[98],{"name":99,"role":31,"phone":100,"phoneExt":18,"email":101},"Marie Méan, PD, MD","+41 (0)79 556 69 17","marie.mean@chuv.ch",{"facility":103,"status":37,"city":104,"state":18,"zip":18,"country":39,"countryCode":40,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"University Hospital Zürich","Zurich",{"type":42,"coordinates":106},[107,108],8.55,47.36667,{"lat":108,"lon":107},[111],{"name":112,"role":31,"phone":113,"phoneExt":18,"email":114},"Stefano Barco, Prof. Dr. med. et phil.","+41 (0)43 253 11 50","stefano.barco@usz.ch",{"type":116,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100603978","early-exercise-based-rehabilitation-in-patients-hospitalized-for-acute-pulmonary-embolism-100603978",false,"NCT07143539","Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism","Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial","RehabPE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days\n3. Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission\n4. Written informed consent\n\nExclusion Criteria:\n\n1. Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)\n2. Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)\n3. Recently completed (i.e., \\\u003C6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication\n4. Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)\n5. Contraindication to anticoagulation\n6. Life expectancy \\\u003C1 year based on the treating physician's clinical judgement\n7. Known pregnancy\n8. Inability to speak German or French\n9. Participation in another study that prohibits concurrent participation in RehabPE\n10. Unable to provide informed consent (e.g., due to dementia)\n11. Unwilling to provide informed consent\n12. Prior enrollment in this study","ALL","18 Years",{"count":128,"type":129},160,"ESTIMATED","INTERVENTIONAL",[132],"NA","Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with anticoagulation (blood thinners). The randomized RehabPE trial investigates whether an early, structured rehabilitation program with physical training and patient education can prevent such long-term effects.\n\nThe study includes hospitalized patients with acute symptomatic PE who are at increased risk of impaired quality of life three months after diagnosis. After informed consent, patients are randomly assigned to one of two groups: one receives an early 6-8-week, center-based rehabilitation program; the other receives standard follow-up care without rehabilitation. The intervention group completes 16-18 outpatient sessions of endurance and strength training, along with two education sessions covering the condition, treatment, and symptom management.\n\nOver 180 days, changes in quality of life, physical exercise capacity, breathlessness, and psychological symptoms, and the time to return to work \u002F usual daily activities will be monitored and compared between groups.",[135,136,137,138,139,140,141,142,143,144],"Venous Thromboembolism (VTE)","Exercise Therapy","Quality of Life (QOL)","Anxiety Depression","Humans","Exercise Tolerance","Rehabilitation Exercise","Dyspnea","Functional Status","Pulmonary Embolism (Diagnosis)",[146,147,148,149,150,151,152,153,154],"pulmonary embolism","deep vein thrombosis","excercise-based rehabilitation","post-PE syndrome","health-related quality of life","anxiety","depression","dyspnea","impact of early excercise-based rehabilitation","2026-06-11",{"date":157,"type":158},"2026-06-12","ACTUAL",{"date":160,"type":158},"2025-12-17",{"date":162,"type":129},"2028-06",{"name":5,"class":6},6]